The purpose of this study was to investigate the effect of low intensity exercise and artificial light irradiation on serotonin, dopamine, norepinephrine expression and neurogenesis in rat brain. Male sprague-dawley (SD) rats were randomly assigned into four groups (n=9 in each group): the control g...
The purpose of this study was to investigate the effect of low intensity exercise and artificial light irradiation on serotonin, dopamine, norepinephrine expression and neurogenesis in rat brain. Male sprague-dawley (SD) rats were randomly assigned into four groups (n=9 in each group): the control group (CG), the exercise group (EG), the light group (LG), and the exercise·light group (ELG). The rats in EG were made to run on treadmill (5days/week, 30min/day) for four weeks. LG was irradiated (5days/week, 30min/day, 10,000Lux) for four weeks. ELG was made to run on treadmill while being irradiated for four weeks. And CG remained sedentary for four weeks. The results of the study are as follows: First, serotonin expression in EG, LG, and ELG increased significantly compared to CG in the raphe. But there was no significant difference among EG, LG, and ELG. Second, dopamine expression in EG, LG, and ELG increased significantly compared to CG in the substantia nigra. But there was no significant difference among EG, LG, and ELG. Third, norepinephrine expression in EG and ELG increased significantly compared to CG in the locus ceruleus. It also increased in LG compared to CG, but there was no significant difference. There was no significant difference among EG, LG, and ELG. Fourth, hippocampal neurogenesis (BrdU) in LG and ELG increased significantly compared to CG in the hippocampal dentate gyrus. It also increased in EG compared to CG, but there was no significant difference. There was no significant difference among EG, LG, and ELG. Finally, BDNF (brain-derived neurotrophic factor) expression in EG, LG and ELG increased compared to CG in the hippocampus. However, there was no significant difference among them. The overall results showed that low-intensity exercise and bright-light therapy had a positive effect on the biochemical changes in the brain. Therefore, I suggest that getting moderate exercise and bright-light on childhood would stabilize children's emotions and improve addictive and aggressive behavior. I also suggest that they would improve memory and learning ability.
The purpose of this study was to investigate the effect of low intensity exercise and artificial light irradiation on serotonin, dopamine, norepinephrine expression and neurogenesis in rat brain. Male sprague-dawley (SD) rats were randomly assigned into four groups (n=9 in each group): the control group (CG), the exercise group (EG), the light group (LG), and the exercise·light group (ELG). The rats in EG were made to run on treadmill (5days/week, 30min/day) for four weeks. LG was irradiated (5days/week, 30min/day, 10,000Lux) for four weeks. ELG was made to run on treadmill while being irradiated for four weeks. And CG remained sedentary for four weeks. The results of the study are as follows: First, serotonin expression in EG, LG, and ELG increased significantly compared to CG in the raphe. But there was no significant difference among EG, LG, and ELG. Second, dopamine expression in EG, LG, and ELG increased significantly compared to CG in the substantia nigra. But there was no significant difference among EG, LG, and ELG. Third, norepinephrine expression in EG and ELG increased significantly compared to CG in the locus ceruleus. It also increased in LG compared to CG, but there was no significant difference. There was no significant difference among EG, LG, and ELG. Fourth, hippocampal neurogenesis (BrdU) in LG and ELG increased significantly compared to CG in the hippocampal dentate gyrus. It also increased in EG compared to CG, but there was no significant difference. There was no significant difference among EG, LG, and ELG. Finally, BDNF (brain-derived neurotrophic factor) expression in EG, LG and ELG increased compared to CG in the hippocampus. However, there was no significant difference among them. The overall results showed that low-intensity exercise and bright-light therapy had a positive effect on the biochemical changes in the brain. Therefore, I suggest that getting moderate exercise and bright-light on childhood would stabilize children's emotions and improve addictive and aggressive behavior. I also suggest that they would improve memory and learning ability.
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