Nowadays, Cancer diagnosis and treatment become highly interested due to the widespread occurrence of the diseases, high mortality, and recurrence after therapy. To develop the diagnosis system for cancers or various diseases, many kinds of biosensor have been researched. Biosensors for blood glucos...
Nowadays, Cancer diagnosis and treatment become highly interested due to the widespread occurrence of the diseases, high mortality, and recurrence after therapy. To develop the diagnosis system for cancers or various diseases, many kinds of biosensor have been researched. Biosensors for blood glucose or blood gas analysis have been already used in medical applications. Few are applying to clinical trials for cancer, and they still can not make a satisfying result. Meanwhile, semiconductor-based biosensors have high sensitivity, high processing speed, and low cost and they can provide trustworthy information. Capacitive EIS structure, ISFET, and LAPS are typical semiconductor-based biosensors. Applications for these sensors are in the fields of medicine, agriculture, biotechnology as well as the military and bioterrorism detection and prevention. Until now, the cancer diagnosis and treatment is typically focused on removal of cancer cell (CTC) and CSC has been excluded from the medical purposes. These cancer cells are generated by the genetic changes in a specific cell during the process of cancer. Evidence for the existence of CSC has been reported and their properties include self-renewal that drives tumorigenesis, differentiation that contributes to cellular heterogeneity, and the number of these cells is very small. In addition, mechanisms for resistance to the formal anti-cancer treatment, recurrence, and metastasis can be explained. Here, the fundamental research for semiconductor-based biosensor to detect CCSC as a new paradigm was studied. For ISFET-based sensor, EIS structures which have a similar structure to ISFET were fabricated. SiO2 and Al2O3 layer were used as gate dielectrics. In C-V measurement, C-V characteristic can be measured correctly at low frequencies (100~200 ㎐). The sensitivities of SiO2 and Al2O3 films for EIS structure were 33±1 mV/pH and 50±2 mV/pH, respectively. In the second chapter a biosensor will introduce, and the following chapters will describe biochemistry such as water, ion channel, cancer cell, and antigen-antibody reaction (Chapter 3), modeling of oxide/electrolyte interfaces (Chapter 4), and field-effect sensors (Chapter 5). In chapter 6, the fabrications and characteristics of EIS structure and ISFET biosensor for this research will be described. In the last chapter, the main results of the research will be presented and discussed the options for future work.
Nowadays, Cancer diagnosis and treatment become highly interested due to the widespread occurrence of the diseases, high mortality, and recurrence after therapy. To develop the diagnosis system for cancers or various diseases, many kinds of biosensor have been researched. Biosensors for blood glucose or blood gas analysis have been already used in medical applications. Few are applying to clinical trials for cancer, and they still can not make a satisfying result. Meanwhile, semiconductor-based biosensors have high sensitivity, high processing speed, and low cost and they can provide trustworthy information. Capacitive EIS structure, ISFET, and LAPS are typical semiconductor-based biosensors. Applications for these sensors are in the fields of medicine, agriculture, biotechnology as well as the military and bioterrorism detection and prevention. Until now, the cancer diagnosis and treatment is typically focused on removal of cancer cell (CTC) and CSC has been excluded from the medical purposes. These cancer cells are generated by the genetic changes in a specific cell during the process of cancer. Evidence for the existence of CSC has been reported and their properties include self-renewal that drives tumorigenesis, differentiation that contributes to cellular heterogeneity, and the number of these cells is very small. In addition, mechanisms for resistance to the formal anti-cancer treatment, recurrence, and metastasis can be explained. Here, the fundamental research for semiconductor-based biosensor to detect CCSC as a new paradigm was studied. For ISFET-based sensor, EIS structures which have a similar structure to ISFET were fabricated. SiO2 and Al2O3 layer were used as gate dielectrics. In C-V measurement, C-V characteristic can be measured correctly at low frequencies (100~200 ㎐). The sensitivities of SiO2 and Al2O3 films for EIS structure were 33±1 mV/pH and 50±2 mV/pH, respectively. In the second chapter a biosensor will introduce, and the following chapters will describe biochemistry such as water, ion channel, cancer cell, and antigen-antibody reaction (Chapter 3), modeling of oxide/electrolyte interfaces (Chapter 4), and field-effect sensors (Chapter 5). In chapter 6, the fabrications and characteristics of EIS structure and ISFET biosensor for this research will be described. In the last chapter, the main results of the research will be presented and discussed the options for future work.
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