The improving effect of green tea extract (GTE) or l-theanine on scopolamine or Aβ1-42-induced memory impairment in mice was investigated. GTE(12 and 24mg/kg) and l-theanine(2 and 4mg/kg) were orally adminstered in the drinking water for 3 weeks. In the behavioral pharmacological experiments, GTE an...
The improving effect of green tea extract (GTE) or l-theanine on scopolamine or Aβ1-42-induced memory impairment in mice was investigated. GTE(12 and 24mg/kg) and l-theanine(2 and 4mg/kg) were orally adminstered in the drinking water for 3 weeks. In the behavioral pharmacological experiments, GTE and l-theanine reduced scopolamine(1mg/kg, ip) or Aβ1-42(2ug/mouse, icv) induced memory impairment determined by the passive avoidance-performance and the water-maze tests. In the histochemical experiments, GTE and l-theanine inhibited acetylcholinesterase activity in the cortex and hippocampus of the mice brain. They also reduced Aβ1-42 levels accompanied with the inhibition of β-secretase activity and Aβ1-42-induced neuronal cell death. Oral treatment of l-theanine fortified GTE (green tea extract 24mg/kg and l-theanine 4mg/kg; TF-GTE) in the drinking water was carried out for 3 weeks. In the behavioral pharmacological experiments, TF-GTE showed much higher improvement on memory impairment compared with green tea extract and l-theanine, respectively. In the histochemical experiments, it inhibited acetylcholinesterase activity more significantly in the cortex and hippocampus in the mice brain, and reduced Aβ1-42 levels accompanied with the inhibition of β-secretase activity and Aβ1-42-induced neuronal cell death. In the randomized, double-blind, placebo-controlled clincal study, the improving effects of TF-GTE(LGNC-07) on memory and attention in Ninety-one subjects with mild cognitive impairment was investigated. The treatment group took 1,680mg of LGNC-07, and placebo group received an equivalent amount of maltodextrin and lactose for 16 weeks. Neurophysiological tests(Rey-Kim memory test and Korean color-word Stroop test) and electroencephalography were conducted to evaluate the improving effect of LGNC-07 on memory and attention. Further analyses were stratified by baseline severity to evaluate treatment response on the degree of impairment(MMSE-K 21-23 and 24-26). LGNC-07 led to improvements in memory by marginally significantly increasing delayed recognition in the Rey-Kim memory test(p=0.0572). Stratified analyses showed that LGNC-07 improved memory and selective attention by significantly increasing the Rey-Kim memory quotient and Stroop word reading in the subjects with MMSE-K scores of 21-23(LGNC-07, n=11; placebo, n=9). Electroencephalograms were recorded in 24 randomly selected subjects hourly for 3 hours in eye-open, eye-closed and reading states after a single dose of LGNC-07 and placebo, respectively. Brain theta waves, an indicator of cognitive alertness, were increased significantly in the temporal, frontal, parietal, and occipital areas after 3 hours in the eye-open and reading states. Therefore, these studies suggest that TF-GTE(the combination of GTE and l-theanine) has potential as an intervention for memory improvement.
The improving effect of green tea extract (GTE) or l-theanine on scopolamine or Aβ1-42-induced memory impairment in mice was investigated. GTE(12 and 24mg/kg) and l-theanine(2 and 4mg/kg) were orally adminstered in the drinking water for 3 weeks. In the behavioral pharmacological experiments, GTE and l-theanine reduced scopolamine(1mg/kg, ip) or Aβ1-42(2ug/mouse, icv) induced memory impairment determined by the passive avoidance-performance and the water-maze tests. In the histochemical experiments, GTE and l-theanine inhibited acetylcholinesterase activity in the cortex and hippocampus of the mice brain. They also reduced Aβ1-42 levels accompanied with the inhibition of β-secretase activity and Aβ1-42-induced neuronal cell death. Oral treatment of l-theanine fortified GTE (green tea extract 24mg/kg and l-theanine 4mg/kg; TF-GTE) in the drinking water was carried out for 3 weeks. In the behavioral pharmacological experiments, TF-GTE showed much higher improvement on memory impairment compared with green tea extract and l-theanine, respectively. In the histochemical experiments, it inhibited acetylcholinesterase activity more significantly in the cortex and hippocampus in the mice brain, and reduced Aβ1-42 levels accompanied with the inhibition of β-secretase activity and Aβ1-42-induced neuronal cell death. In the randomized, double-blind, placebo-controlled clincal study, the improving effects of TF-GTE(LGNC-07) on memory and attention in Ninety-one subjects with mild cognitive impairment was investigated. The treatment group took 1,680mg of LGNC-07, and placebo group received an equivalent amount of maltodextrin and lactose for 16 weeks. Neurophysiological tests(Rey-Kim memory test and Korean color-word Stroop test) and electroencephalography were conducted to evaluate the improving effect of LGNC-07 on memory and attention. Further analyses were stratified by baseline severity to evaluate treatment response on the degree of impairment(MMSE-K 21-23 and 24-26). LGNC-07 led to improvements in memory by marginally significantly increasing delayed recognition in the Rey-Kim memory test(p=0.0572). Stratified analyses showed that LGNC-07 improved memory and selective attention by significantly increasing the Rey-Kim memory quotient and Stroop word reading in the subjects with MMSE-K scores of 21-23(LGNC-07, n=11; placebo, n=9). Electroencephalograms were recorded in 24 randomly selected subjects hourly for 3 hours in eye-open, eye-closed and reading states after a single dose of LGNC-07 and placebo, respectively. Brain theta waves, an indicator of cognitive alertness, were increased significantly in the temporal, frontal, parietal, and occipital areas after 3 hours in the eye-open and reading states. Therefore, these studies suggest that TF-GTE(the combination of GTE and l-theanine) has potential as an intervention for memory improvement.
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