[논문]포공영(蒲公英) 약침(藥鍼)이 Rat의 Adjuvant 관절염(關節炎)에 미치는 영향(影響)

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doi:10.3831/kpi.1999.2.1.135

포공영(蒲公英) 약침(藥鍼)이 Rat의 Adjuvant 관절염(關節炎)에 미치는 영향(影響)
Effects of Herba Taraxaci Herbal-Acupuncture on Adjuvant Arthritis in Rats 원문보기

大韓藥鍼學會誌 = Journal of Korean institute of herbal-acupuncture, v.2 no.1 = no.2, 1999년, pp.135 - 152

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To investigate effects of Taraxaci herbal-acupuncture on Adjuvant Arthritis in rats, the edema rate, the number of WBC, the quantity of total protein, albumin and globulin in the blood serum and histological test of the muscular tissue were measured in the arthritis part. 1. After elicitating arthritis of Sprague Dawely(SD) rats by injection of Freund's complets adjuvant for 2 weeks, saline was injected for the Exp. I group and Taraxaci herbal-acupuncture was injected for the Exp. II group during 30days. Selected point was $ST_{35}$ in both the groups. And then the volume of the paw were checked. The volume of paw was $0.84{\pm}0.14mm$ in the Exp. I group and $0.38{\pm}0.17mm$ in the Exp. II group, the swelling of the paw was restricted significantly in the Exp. II group(p<0.05) 2. The number of WBC was $10.34{\pm}0.14(10^3/ml)$ in the normal group and $37.47{\pm}5.46(10^3/ml)$ in the Exp. I group. It was $20.39{\pm}4.23(10^3/ml)$ in the Exp. II group. This fact showed that the group Exp. II was more effective than the Exp. I group in the treatment of arthritis(p<0.05) 3. The content of the total protein in the blood serum was $6.14{\pm}0.43g/dl$ in the normal group, $7.95{\pm}0.94g/dl$ in the Exp. I group, and $6.38{\pm}1.75g/dl$ in the Exp. II group. This fact showed that the group Exp. II was more effective than the Exp. I group in the treatment of arthritis(p<0.05) 4. The contents of albumin in the blood serum was $2.94{\pm}0.13g/dl$ in the normal group, $2.01{\pm}0.48g/dl$ in the Exp. I group. and $2.71{\pm}0.34g/dl$ in the Exp. II group. This fact showed that the group Exp. II was more effective than the Exp. I group in the treatment of arthritis(p<0.05) 5. The contents of globulin in the blood serum was $3.19{\pm}0.48g/dl$ in the normal group, $4.70{\pm}1.26g/dl$ in the Exp. I group. and $3.67{\pm}0.56g/dl$ in the Exp. II group. There was no significance in the serum globulin between Exp. II group and Exp. I group from the stastical analysis 6. In histological finding, because of severe inflammatory reaction, remarkably irregular tissue and large amount of inflammatory cells were found in the Exp. I group. But the Exp. II group showed small amount of inflammatory cells, the refrained inflammatory state and even recovering state. From these results, it is showed Taraxaci herbal-acupuncture refrain inflammatory reaction and muscular tissue necrosis in SD rats paw were induced by Freund's complete adjuvant

참고문헌 (5)

Anderson, G D, Hauser, S D, McGarity, K L, Bremer, M E, Isakson, P C, Gregory, S A. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis.. The Journal of clinical investigation, vol.97, no.11, 2672-2679.

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Hall, T. J., Jagher, B., Schaeublin, M., Wiesenberg, I.. The analgesic drug buprenorphine inhibits osteoclastic bone resorption in vitro, but is proinflammatory in rat adjuvant arthritis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], vol.45, no.6, 299-302.

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Braga, P. C., Soldavini, E., Pecile, A., Sibilia, V., Netti, C.. Involvement of H1 receptors in the central antinociceptive effect of histamine: Pharmacological dissection by electrophysiological analysis. Experientia, vol.52, no.1, 60-65.

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Droesse, M., Tangen, G., Gummelt, I., Kirchhoff, H., Washburn, L. R., Rosengarten, R.. Major membrane proteins and lipoproteins as highly variable immunogenic surface components and strain-specific antigenic markers of Mycoplasma arthritidis. Microbiology, vol.141, no.12, 3207-3219.

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Malmström, V, Michaëlsson, E, Burkhardt, H, Mattsson, R, Vuorio, E, Holmdahl, R. Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis.. Proceedings of the National Academy of Sciences of the United States of America, vol.93, no.9, 4480-4485.

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포공영(蒲公英) 약침(藥鍼)이 Rat의 Adjuvant 관절염(關節炎)에 미치는 영향(影響)
Effects of Herba Taraxaci Herbal-Acupuncture on Adjuvant Arthritis in Rats 원문보기

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포공영(蒲公英) 약침(藥鍼)이 Rat의 Adjuvant 관절염(關節炎)에 미치는 영향(影響) Effects of Herba Taraxaci Herbal-Acupuncture on Adjuvant Arthritis in Rats 원문보기

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포공영(蒲公英) 약침(藥鍼)이 Rat의 Adjuvant 관절염(關節炎)에 미치는 영향(影響)
Effects of Herba Taraxaci Herbal-Acupuncture on Adjuvant Arthritis in Rats 원문보기