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Development of Freeze Drying Analysis Program using Fixed Grid


A multi-dimensional freeze drying analysis program, which took simultaneous heat and mass transfer, sublimation of ice and motion of sublimation front into full account, was developed using finite volume method with fixed grid. The effect due to the motion of sublimation interface was modeled by an enthalpy formulation streamlined for the freeze drying problems. The efficiency and accuracy of the program was validated by solving one- and two-dimensional freeze drying problems frequently encountered in industrial processes. Finally, the freeze drying processes of cylinder and slab objects with permeable side surfaces were simulated, which demonstrated the capability of the present analysis program in solving multi-dimensional freeze drying problems with complex sublimation interface configurations.

참고문헌 (18)

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  4. Sadikoglu, H. and Liapis, A. I., 1997, Math-ematical modeling of the primary and sec-ondary drying stages of bulk solution freeze-drying in trays: parameter estimation and model discrimination by comparison of theo-retical results with experimental data, Dry-ing Technol., Vol. 15, pp.791-810 
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  10. Liapis, A 1. and Bruttini, R, 1994, A theory for the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes: comparison between experimental data and theory, Separ. Technol., Vol. 4, pp. 144-155 
  11. Wang, Z.H. and Shi, M. H., 1998, Numerical study on sublimation-condensation phenom-ena during microwave freeze drying, Chem. Eng. Sci., Vol. 53, pp.3189-3197 
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  15. Millman, M.J., Liapis, A. I. and Marchello, J. M., 1985, An analysis of the lyophilization process using a sorption-sublimation model and various operation policies, AIChE J., Vol. 31, pp.1594-1604 
  16. Ang, T. K, Ford, J. D. and Pei, D. C. T., 1977, Microwave freeze-drying of food: a theoreti-cal investigation, Int. J. Heat Mass Trans-fer, Vol. 20, pp.517-526 
  17. Wang, Z. H. and Shi, M. H., 1998, The effect of sublimation-condensation region on heat and mass transfer during microwave freeze drying, J Heat Transfer, Vol. 120, pp.654-660 
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이 논문을 인용한 문헌 (1)

  1. Choi, Yong-Don ; Kang, Yong-Tae ; Kim, Nae-Hyun ; Kim, Man-Hoe ; Park, Kyoung-Kuhn ; Park, Byung-Yoon ; Park, Jin-Chul ; Hong, Hi-Ki 2007. "Recent Progress in Air Conditioning and Refrigeration Research - A Review of Papers Published in the Korean Journal of Air-Conditioning and Refrigeration Engineering in 2004 and 2005 -" 설비공학논문집 = Korean journal of air-conditioning and refrigeration engineering, 19(1): 94~131 


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