[논문]Large-Scale Fermentation for the Production of Teicoplanin From a Mutant of Actinoplanes teichomyceticus

LEE JAE-CHAN; MIN JUNG-WON; PARK DONG-JIN; SON KWANG HEE; YOON KI-HONG; PARK HAE-RYONG; PARK YOUNG-SOO; KWON MU-GIL; LEE JUNG-MIN; KIM CHANG-JIN

Large-Scale Fermentation for the Production of Teicoplanin From a Mutant of Actinoplanes teichomyceticus 원문보기

Journal of microbiology and biotechnology, v.15 no.4, 2005년, pp.787 - 791

LEE JAE-CHAN (Korea Research Institute of Bioscience & Biotechnology) , MIN JUNG-WON (Korea Research Institute of Bioscience & Biotechnology) , PARK DONG-JIN (Korea Research Institute of Bioscience & Biotechnology) , SON KWANG HEE (Korea Research Institute of Bioscience & Biotechnology) , YOON KI-HONG (School of Food Science & Biotechnology, Woosong University) , PARK HAE-RYONG (Division of Food Science and Biotechnology, Kyungnam University) , PARK YOUNG-SOO (Central Research Center, Kunwha Pharmaceutical Co.) , KWON MU-GIL (Central Research Center, Kunwha Pharmaceutical Co.) , LEE JUNG-MIN (Korea Research Institute of Bioscience & Biotechnology) , KIM CHANG-JIN (Korea Research Institute of Bioscience & Biotechnology)

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Mutation and its pilot-scale fermentation were conducted for the production of teicoplanin from Actinoplanes teichomyceticus. The fermentation medium was optimized by replacement and Plackett-Burman experimental design. A maximum production of 1,500 mg/l teicoplanin was obtained by pilot-scale fermentation in an optimized medium containing (g/l): 30 g maltodextrin, 5 g glucose, 5 g yeast extract, 5 g soybean meal, 0.5 g $MgSO_4{\cdot}7H_2O$, 0.1 g NaCl, 0.1 g $CaCl_2{\cdot}2H_2O$, and 50 g Diaion HP-20. The production of teicoplanin was improved 3-fold from the parental strain by mutation, media optimization, and fermentation, and laboratory-scale fermentation was successfully demonstrated in a pilot-scale fermenter for the industrial production of teicoplanin.

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Large-Scale Fermentation for the Production of Teicoplanin From a Mutant of Actinoplanes teichomyceticus 원문보기

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Large-Scale Fermentation for the Production of Teicoplanin From a Mutant of Actinoplanes teichomyceticus 원문보기

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