• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


Wogonin (5,7-dihydroxy-8-methoxyflavone) has been reported to exhibit a variety of biological properties including anti-inflammatory and neuroprotective functions. In this study, biological activities of diverse synthetic wogonin derivatives have been evaluated in two experimental cell culture models. Inhibitory activities of wogonin derivatives on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 microglial cells and on hydrogen peroxide ($H_{2}O_2$)-induced neuronal cell death in SH-SY5Y human neuroblastoma were examined. Wogonin derivatives such as WS2 and WS3 showed more potent suppressive activities on LPS-induced NO production and $H_{2}O_2$-induced cytotoxicity than wogonin itself. In addition, thiol substitution played a minor role in enhancing the activities of the derivatives. These findings may contribute to the development of novel anti-inflammatory and neuroprotective agents derived from wogonin.

참고문헌 (18)

  1. Chandra, J., Samali, A., and Orrenius, S., Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol. Med., 29, 323-333 (2000) 
  2. Chen, Y. C., Shen, S. C., Chen, L. G., Lee, T. J., and Yang, L. L., Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem. Pharmacol., 61, 1417-1427 (2001) 
  3. Dao, T. T., Kim, S. B., Sin, K. S., Kim, S., Kim, H. P., and Park, H., Synthesis and biological activities of 8-arylflavones. Arch. Pharm. Res., 27, 278-282 (2004b) 
  4. Lee, H., Kim, Y. O., Kim, H., Kim, S. Y., Noh, H. S., Kang, S. S., Cho, G. J., Choi, W. S., and Suk, K., Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. Faseb. J., 17, 1943-1944 (2003) 
  5. Murphy, M. P., Nitric oxide and cell death. Biochim. Biophys. Acta., 1411, 401-414 (1999) 
  6. Simonian, N. A. and Coyle, J. T., Oxidative stress in neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol., 36, 83-106 (1996) 
  7. Gao, Z., Huang, K., Yang, X. and Xu, H., Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim. Biophys. Acta, 1472, 643-650 (1999) 
  8. Middleton, E., Jr., Kandaswami, C., and Theoharides, T. C., The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev., 52, 673-751 (2000) 
  9. Wakabayashi, I. and Yasui, K., Wogonin inhibits inducible prostaglandin E(2) production in macrophages. Eur. J. Pharmacol., 406, 477-481 (2000) 
  10. Liu, B., Gao, H. M., Wang, J. Y., Jeohn, G. H., Cooper, C. L., and Hong, J. S., Role of nitric oxide in inflammation-mediated neurodegeneration. Ann. N. Y. Acad. Sci., 962, 318-331 (2002) 
  11. Kim, H. K., Cheon, B. S., Kim, Y. H., Kim, S. Y., and Kim, H. P., Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem. Pharmacol., 58, 759-765 (1999) 
  12. Gao, Z., Huang, K. and Xu, H., Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacol. Res., 43, 173-178 (2001) 
  13. Blasi, E., Barluzzi, R., Bocchini, V., Mazzolla, R., and Bistoni, F., Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J. Neuroimmunol., 27, 229-237 (1990) 
  14. Dao, T. T., Chi, Y. S., Kim, J., Kim, H. P., Kim, S., and Park, H., Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives. Bioorg Med. Chem. Lett., 14, 1165-1167 (2004a) 
  15. Green, L. C., Wagner, D. A., Glogowski, J., Skipper, P. L., Wishnok, J. S., and Tannenbaum, S. R., Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem., 126, 131-138 (1982) 
  16. Kang, S. S., Lee, J. Y., Choi, Y. K., Kim, G. S., and Han, B. H., Neuroprotective effects of flavones on hydrogen peroxideinduced apoptosis in SH-SY5Y neuroblostoma cells. Bioorg. Med. Chem. Lett., 14, 2261-2264 (2004) 
  17. Kim, S. S., Kong, P. J., Kim, B. S., Sheen, D. H., Nam, S. Y., and Chun, W., Inhibitory action of minocycline on lipopolysaccharide- induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells. Arch. Pharm. Res., 27, 314-318 (2004) 
  18. Cho, J. and Lee, H. K., Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. Eur. J. Pharmacol., 485, 105-110 (2004) 

이 논문을 인용한 문헌 (1)

  1. 2008. "" Journal of microbiology and biotechnology, 18(12): 1990~1996 

DOI 인용 스타일