[논문]Lipid Lowering Effect of Anthocyanin-Pigmented Rice Bran in Streptozotocin-Induced Diabetic Male Rats

Han, Hae-Kyoung; Choi, Sung-Sook; Shin, Jin-Chul; Chung, Ha-Sook

doi:10.3746/jfn.2008.13.4.276

Lipid Lowering Effect of Anthocyanin-Pigmented Rice Bran in Streptozotocin-Induced Diabetic Male Rats 원문보기

Journal of food science and nutrition, v.13 no.4, 2008년, pp.276 - 280

Han, Hae-Kyoung (Department of Foods and Nutrition, DukSung Women's University) , Choi, Sung-Sook (Department of Foods and Nutrition, DukSung Women's University) , Shin, Jin-Chul (National Crop Experiment Station, Rural Development Administration) , Chung, Ha-Sook (Department of Foods and Nutrition, DukSung Women's University)

Abstract ▼ AI-Helper

Oryza sativa cv. Heugjinjubyeo, an anthocyanin-pigmented rice variety, is well known to contain high levels of bioactive phytochemicals, anthocyanin, quinolone alkaloids and phenolic acids. Here, we studied the inhibitory effect of Oryza sativa cv. Heugjinjubyeo bran on the absorption of dietary fat in streptozotocin-induced diabetic Sprague-Dawley male rats. For these experiments, experimental animals were divided into four groups: normal, diabetic-control and two experimental groups that were fed 1.0 g or 2.0 g/kg body weight/day of Oryza sativa cv. Heugjinjubyeo bran supplement for 14 days. As a result, liver glycogen levels increased significantly by 65% and 32% in groups receiving 1.0 g and 2.0 g/kg body weight/day, respectively, compared to diabetic-control. Liver cholesterol levels were significantly lower by 8.3% and 14.5% in the groups fed 1.0 g and 2.0 g of anthocyanin- pigmented rice extracts, respectively.

주제어

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가설 설정

3)Values with different superscripts within a row are significantly different at p< 0.05.

대상 데이터

The experimental feeding period was 14 days. The rats were randomized to four groups of 7 male rats each. The dosage of APR ethanolic extract used was based on our earlier study (1).

이론/모형

Tissue samples were digested with hot, concentrated KOH and treated with 2% anthrone reagent. Glycogen content in liver and muscle was determined by a colori-metric method (9). Liver cholesterol and triglyceride lev-els were determined by an enzymatic method (10) and the Trinder method (11), respectively.

성능/효과

Eide et al previously reported that oral ad-ministration of garlic extract for 14 days significantly decreased serum glucose, triglycerides, urea, uric acid, creatinine, AST and ALT levels (38). In conclusion, the present study indicates that lipid metabolism in STZ-dia-betic male rats can be improved by APR bran supple-mentation, which may also be beneficial for prevention of diabetic complications caused by lipid peroxidation.

참고문헌 (38)

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