[논문]다양한 임무 부여시 기능적 자기공명영상에서 관찰된 소뇌의 활성화

황승배; 곽효성; 이상용; 진공용; 한영민; 김영곤; 정경호

다양한 임무 부여시 기능적 자기공명영상에서 관찰된 소뇌의 활성화
Cerebellar Activation Related to Various Tasks Using fMRI 원문보기

대한자기공명의과학회지 = Journal of the Korean society of magnetic resonance in medicine, v.13 no.1, 2009년, pp.47 - 53

황승배 (전북대학교 의학전문대학원 영상의학과) , 곽효성 (전북대학교 의학전문대학원 영상의학과) , 이상용 (전북대학교 의학전문대학원 영상의학과) , 진공용 (전북대학교 의학전문대학원 영상의학과) , 한영민 (전북대학교 의학전문대학원 영상의학과) , 김영곤 (전북대학교 의학전문대학원 영상의학과) , 정경호 (전북대학교 의학전문대학원 영상의학과)

초록
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목적: 기능적 자기 공명 영상을 이용하여 운동, 감각, 단어만들기, 듣고이해하기, 그리고 기억하기 등의 자극을 주어 소뇌 활성화를 평가하는 것이다. 대상 및 방법: 11명의 건강한 오른손잡이 지원자 (남: 여, 6:5, mean age: 27.4세)를 대상으로 1.5T 자기공명영상기기의 BOLD기법을 이용하여 뇌 전체를 축상면으로 기능적 자기공명영상을 얻었고 패러다임은 5번의 자극과 휴식을 반복 사용하였다. 왼쪽 손가락의 복잡한 운동, 감각 자극, 단어만들기, 듣고이해하기, 그리고 기억하기를 활성화 자극으로 사용하였고, 한계치는 p = 0.001를 사용하여, 소뇌 내 활성화를 SPM 5를 이용하여 활성화된 영역의 부위와 활성화정도를 평가하였다. 결과: 소뇌 활성화는 운동, 단어만들기, 그리고 기억하기에서 관찰되었다. 운동 자극에서는 949 영역이 활성화되었고 평균반응정도는 0.68이었고 단어만들기 자극에서는 319 영역이 활성화되었고 평균반응정도는 0.15이었으며 기억자극에서는 330의 영역이 활성화되었고 평균반응정도는 0.26이었다. 결론: 소뇌는 운동, 단어만들기, 그리고 기억하기등 다양한 기능적 자극에 관련이 되어 있으며, 이중에서도 운동기능에 가장 연관이 있었다. 기능적 자기 공명 영상은 소뇌 기능 연구하는 방법으로 이용이 가능할 것이다.

Abstract ▼ AI-Helper

Purpose : Although it's been known for half a century that unique structures have evolved in the cerebellum and they then became greatly enlarged in the human brain, the function of these structures still remains unknown. The purpose of this study was to assess cerebellar activation during motor, sensory, word generation, listening comprehension, and working memory tasks with using functional magnetic resonance imaging (fMRI). Materials and Methods : Eleven healthy right-handed subjects (Male: female, 6:5, mean age: 27.4years) were imaged on a Siemens 1.5T scanner. Whole brain functional maps were acquired using BOLD EPI sequences in the axial plane. Each paradigm consisted of five epochs of activation vs. the control condition. The activation tasks consisted of left finger complex movement, sensory stimulation of the left hand, word generation, listening comprehension, and working memory tasks. The reference function was a boxcar waveform. The activation maps were thresholded at p = 0.001. SPM 5 evaluated the activated areas and responses within the cerebellum. Results : Cerebellar activation was observed on motor task, word generation task, and working memory task. There were 949 activated areas and the mean fitted and adjusted response was 0.68 during the motor task. There were 319 activated areas and the mean fitted and adjusted response was 0.15 during the word generation task. There were 330 activated areas and the mean fitted and adjusted response was 0.26 during the working memory task. Conclusion : Our results suggest that the cerebellum is involved in a variety of functional tasks, including motor, word generation, and working memory tasks. However, during the motor task, the cerebellum showed a large activated area and a high response. Cerebellar function can be evaluated by fMRI.

주제어

AI 본문요약
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문제 정의

The survey of cerebellar activation that is taken during the motor task is worthwhile to evaluate the restoration of cerebrovascular accidents. The cerebellar activation is clearly changed in the cerebellar hemisphere contralateral to the injured corticospinal tract for stroke patients having good recovery.

제안 방법

The activated areas and the fitted and adjusted responses of those volunteers who demonstrated any activation of the cerebellum were tabulated and compared across the various tasks. The Wilcoxon signed rank test was used to test that the fitted and adjusted responses within the cerebellum differed among the motor, word generation, and working memory tasks for each subject.
The fMRI SPM statistical program was used to estimate the effects of conditions at each voxel according to the general linear model. The analysis was entered as an epoch design of the fixed response/box car form. Activation maps were thresholded at p = 0.
However, the topographic relationships and responses among the cerebellar areas activated by different functional tasks are unclear. The purpose of this study was to assess cerebellar activation during motor, sensory, word generation, listening comprehension, and working memory tasks by performing functional magnetic resonance imaging (fMRI).

대상 데이터

Eleven healthy right-handed volunteers (6 men and 5 women, 22-35 years old, mean age: 27.4years) were the subjects of this study. They had no history of neurological disorder, and at least a college level education.

데이터처리

The normalized images were smoothed using SPM 5. The fMRI SPM statistical program was used to estimate the effects of conditions at each voxel according to the general linear model. The analysis was entered as an epoch design of the fixed response/box car form.

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저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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