천연물 유래 항생제 대체 사료첨가제 Flavo-$SK^{TM}$은 원광대학교 인수공통감염병연구센터에서 1,000종 이상의 천연물로부터 효능평가를 거쳐 개발되었다. 본 연구는 육계 농장에서 대규모 임상 효능평가를 통한 Flavo-$SK^{TM}$의 항균 효과 규명과 항생제 대체 효과를 알아보고자 수행되었다. 20,000 마리의 병아리를 Flavo-$SK^{TM}$ 투여군과 비투여군 2 그룹으로 나누어 31일 동안 육계농장에서 연구가 수행되었다. Flavo-$SK^{TM}$ 투여군에는 항생제가 없는 사료에 Flavo-$SK^{TM}$를 0.29% 배합하여 급여하였고 비투여군은 항생제 포함된 일반 사료를 급여하였다. 연구기간 동안 사료섭취량, 체중, 임상증상을 분석하고 시험종료일에 부검하여 육안검사와 미생물학적 검사 및 병리조직학적 검사를 수행하였다. 연구결과 천연물 유래 항생제 대체 사료첨가제 Flavo-$SK^{TM}$은 육계에 항균효과를 가진 항생제 대체 사료첨가제로서 효과적인 것을 확인할 수 있었다.
천연물 유래 항생제 대체 사료첨가제 Flavo-$SK^{TM}$은 원광대학교 인수공통감염병연구센터에서 1,000종 이상의 천연물로부터 효능평가를 거쳐 개발되었다. 본 연구는 육계 농장에서 대규모 임상 효능평가를 통한 Flavo-$SK^{TM}$의 항균 효과 규명과 항생제 대체 효과를 알아보고자 수행되었다. 20,000 마리의 병아리를 Flavo-$SK^{TM}$ 투여군과 비투여군 2 그룹으로 나누어 31일 동안 육계농장에서 연구가 수행되었다. Flavo-$SK^{TM}$ 투여군에는 항생제가 없는 사료에 Flavo-$SK^{TM}$를 0.29% 배합하여 급여하였고 비투여군은 항생제 포함된 일반 사료를 급여하였다. 연구기간 동안 사료섭취량, 체중, 임상증상을 분석하고 시험종료일에 부검하여 육안검사와 미생물학적 검사 및 병리조직학적 검사를 수행하였다. 연구결과 천연물 유래 항생제 대체 사료첨가제 Flavo-$SK^{TM}$은 육계에 항균효과를 가진 항생제 대체 사료첨가제로서 효과적인 것을 확인할 수 있었다.
The natural herbal antimicrobial additive, Flavo-$SK^{TM}$, was developed by Zoonosis Research Center of Wonkwang University. The purpose of this study was to evaluate the effects of Flavo-$SK^{TM}$ on the health status and performance of growing chickens. This study was conduc...
The natural herbal antimicrobial additive, Flavo-$SK^{TM}$, was developed by Zoonosis Research Center of Wonkwang University. The purpose of this study was to evaluate the effects of Flavo-$SK^{TM}$ on the health status and performance of growing chickens. This study was conducted on the growing chickens (n=20,000) for 31 days in a growing chickens husbandry. The animals were divided with two groups; Flavo-$SK^{TM}$ treated group (n=10,000) and commercial diet feeding group (n=10,000). The Flavo-$SK^{TM}$ treated animals had provided with commercial diet adding the Flavo-$SK^{TM}$ as 0.29%. During the study period, we compared clinical signs, weight increase rate, diet consumption amount, gross finding, necropsy findings and histopathological findings between the treated group and non treated group. As the results of this clinical trial, the natural herbal antimicrobial additive, Flavo-$SK^{TM}$, showed the effects on disease reduction. It is suggested that Flavo-$SK^{TM}$ has the antimicrobial effects.
The natural herbal antimicrobial additive, Flavo-$SK^{TM}$, was developed by Zoonosis Research Center of Wonkwang University. The purpose of this study was to evaluate the effects of Flavo-$SK^{TM}$ on the health status and performance of growing chickens. This study was conducted on the growing chickens (n=20,000) for 31 days in a growing chickens husbandry. The animals were divided with two groups; Flavo-$SK^{TM}$ treated group (n=10,000) and commercial diet feeding group (n=10,000). The Flavo-$SK^{TM}$ treated animals had provided with commercial diet adding the Flavo-$SK^{TM}$ as 0.29%. During the study period, we compared clinical signs, weight increase rate, diet consumption amount, gross finding, necropsy findings and histopathological findings between the treated group and non treated group. As the results of this clinical trial, the natural herbal antimicrobial additive, Flavo-$SK^{TM}$, showed the effects on disease reduction. It is suggested that Flavo-$SK^{TM}$ has the antimicrobial effects.
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문제 정의
, was developed by Zoonosis Research Center of Wonkwang University. In this study, we are aim to evaluate the effects of Flavo-SKTM on the health status and performance of growing chickens. As the results of this clinical trial, the natural herbal antimicrobial additive, Flavo-SKTM, showed the effects on disease reduction.
, was developed by Zoonosis Research Center of Wonkwang University (15,21). In this work, we are aim to evaluate the effects of Flavo-SKTM on the health status and performance of growing chickens.
가설 설정
The macroscopic observation is revealed severe pneumonia changes in the lung and thoracic fluids. B. The dissected lung of control animal showed severe pneumonic lesion. C.
제안 방법
Following the standard management policy of the farm, all studied chickens were managed at same conditions. Considering the 5-week interval for the introduction of all participating animals in the unit and the monitoring period for each chickens (from growing age to slaughter age), the trial lasted over a total period of 31 days. Management of the animals and data recording during the study were carried out under the management of the animals and data recording during the study were carried out under the ethical guidelines of Wonkwang University IACUC.
We found Flavo-SKTM which has revealed very strong antibacterial and antiviral effects during the screening studies (15,21). In this study, we used Flavo-SKTM for experimental materials.
대상 데이터
, over 1000 kinds of herbal materials were tested by Zoonosis Research Center of Wonkwang University (15,21). The herbal specimens were purchased at the University Oriental Drugstore, Iksan, Korea. Voucher specimens were deposited at the Herbarium of the College of Pharmacy, Wonkwang University.
The investigation was carried out on a growing chicken unit with a capacity of 800,000 chickens in Iksan, Korea. 20,000 clinically healthy 1 day-old chickens of good physical condition were distributed in two experimental groups, depending on the inclusion or not of Flavo-SKTM in their feed, as follows: 1) Control group (10,000 chickens): basic on-farm mixed feed: feed without Flavo-SKTM, 2) Treatment group (10,000 chickens): basic on-farm mixed feed containing Flavo-SKTM at the inclusion rate of 0.
When the studied chickens were 31 days old, each 10 chickens per group were randomly selected. They were autopsied at the necropsy room in Center for Animal Resources Development, Wonkwang University, Iksan city, Korea. During the necropsy, we were conducted the gross observation on the pathological lesions.
The herbal specimens were purchased at the University Oriental Drugstore, Iksan, Korea. Voucher specimens were deposited at the Herbarium of the College of Pharmacy, Wonkwang University. Plant material (50 g) was extracted with ethanol under ultrasonic conditions for 3 h, followed by paper filtration.
데이터처리
Student's t-test was used for pair-wise comparisons.
이론/모형
Values for all parameters under study were recorded for each experimental unit and statistical analysis was performed by the use of the general linear model. When appropriate, values are reported as average ± standard deviation.
성능/효과
According to these results, Flavo-SKTM, an herbal antimicrobial compound, was proved a very effective material preventing chicken pathogens and a very safe material for feeding. The concern about antimicrobial additives has stimulated a renewed interest in potential alternatives (5).
2% agarose gel. As the results of PCR analysis, the chickens of control group (2.5%) had revealed positive reactions against Salmonella gallinarum more frequently than those of treatment group (1.25%). According to these results, Flavo-SKTM, an herbal antimicrobial feed additive, was proved a very effective material preventing poultry pathogens.
The chickens of control groups showed frequently severe pneumonia lesions (Fig 3). As the results of histopathological examinations, the chickens of treatment group which were fed Flavo-SKTM for experimental period (31 days) had not significant pathological changes in liver, kidney, small intestine, large intestine and lung. However, the control chickens without feeding Flavo-SKTM showed pathological lesions in liver, kidney, intestine and lung (Table 3).
In this study, the natural herbal antimicrobial additive which was originated from the herb to treat diarrhea and respiratory disease was assessed on the health status and performance of growing chickens. As the results of this clinical trial, Flavo-SKTM showed the effects on respiratory disease and inflammation. The diet consumption efficiency was revealed that the treatment group was better than the control group.
In this study, we are aim to evaluate the effects of Flavo-SKTM on the health status and performance of growing chickens. As the results of this clinical trial, the natural herbal antimicrobial additive, Flavo-SKTM, showed the effects on disease reduction. It is suggested that Flavo-SKTM could be used as the effective alternative for antibiotics.
We found Flavo-SKTM, an herbal antimicrobial compound, which has revealed very strong antibacterial and antiviral effects during the screening studies (15,21). In this study, the natural herbal antimicrobial additive which was originated from the herb to treat diarrhea and respiratory disease was assessed on the health status and performance of growing chickens. As the results of this clinical trial, Flavo-SKTM showed the effects on respiratory disease and inflammation.
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