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NTIS 바로가기韓方眼耳鼻咽喉皮膚科學會誌 = The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, v.23 no.2, 2010년, pp.125 - 138
조희창 (대구한의대학교 안이비인후피부과교실) , 정호준 (대구한의대학교 안이비인후피부과교실) , 김상찬 (대구한의대학교 한의과대학) , 지선영 (대구한의대학교 안이비인후피부과교실)
Objective : The present study was examined to evaluate the effects of Ecliptae Herba on the production of inflammatory mediators in vivo and in vitro. Methods : In cell viability, all three doses of Ecliptae Herba extract (25, 50 and
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
旱蓮草란? | 旱蓮草는 국화과 (Compositae)에 속한 일년생 초본인 한련초 (Eclipta prostrata L)의 전초를 건조한 것으로, 氣味는 凉甘酸하며, 주로 肝腎經에 入하며, 凉血 止血 補腎 益陰의 효능으로, 吐血 喀 血, 鼻出血, 尿血, 血便, 血痢, 刀傷出血, 鬚髮早白, 디프테리아, 淋濁, 帶下, 陰部濕痒을 치료한다1,2). | |
旱蓮草의 효능은? | 旱蓮草는 국화과 (Compositae)에 속한 일년생 초본인 한련초 (Eclipta prostrata L)의 전초를 건조한 것으로, 氣味는 凉甘酸하며, 주로 肝腎經에 入하며, 凉血 止血 補腎 益陰의 효능으로, 吐血 喀 血, 鼻出血, 尿血, 血便, 血痢, 刀傷出血, 鬚髮早白, 디프테리아, 淋濁, 帶下, 陰部濕痒을 치료한다1,2). | |
한련초추출물 (EH)의 항염증 효능을 평가하기 위하여, LPS로 활성화된 설치류 대식세포주인 Raw 264.7 cells에서의 NO의 생성량, iNOS, COX-2, p-I κ B α , NF κ B의 발현 및 IL-1β, IL-6, TNF- α , PGE2에 미치는 EH의 영향 및 carrageenan으로 유도된 rat의 paw edema에 미치는 영향을 살펴본 바 얻은 결론은? | 1. LPS에 의해 증가된 NO는 EH 25, 50, 100 μ g/㎖의 전처치에 유의하게 억제되었으며, EH+LPS는 LPS 단독처치군에 비교하여 세포독성을 나타내지 않았다. 2. EH는 LPS로 증가된 TNF-α, IL-1β, IL-6, PGE2등의 염증매개물을 유의하게 억제하였다. 3. EH는 LPS에 의해 증가된 iNOS의 발현을 유의하게 감소시켰으며, LPS에 의해 증가된 COX-2 activity를 유의하게 억제하였다. 4. EH는 LPS에 의해 증가된 NF κ B의 억제단백질인 I κ B α 의 인산화를 억제하고, 또한 핵분획 에서의 NF κ B의 발현량을 억제하였다. 5. EH는 carrageenan으로 유도된 rat의 paw edema에 대하여 부종정도를 유의하게 억제하였으며, 염증조직에서의 침윤염증세포 및 두께를 유의성있게 감소시켰다. |
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