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NTIS 바로가기大韓韓醫學方劑學會誌 = Herbal formula science, v.19 no.2, 2011년, pp.93 - 108
박영철 (대구가톨릭대학교 GLP센터) , 이지선 (대구가톨릭대학교 GLP센터) , 김민희 (대구가톨릭대학교 GLP센터) , 김동윤 (대구가톨릭대학교 GLP센터) , 이선동 (상지대학교 한의과대학 예방의학교실)
Objectives : Angelica sinensis has been used extensively in Korean traditional medicine. Although thorough clinical trials are lacking, Various pharmacological actions for Angelica sinensis has been identified newly using animal models. In addition, it was reported that reactive intermediates, poten...
핵심어 | 질문 | 논문에서 추출한 답변 |
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당귀의 구성 성분은 무엇인가? | 당귀는 필수지방인 phthalide를 포함하여 phthalide dimers, coumarins, 유기산(organic acid)과 에스테르, polysaccharides, polyacetylenes, 비타민, 구리고 아미노산 등이 함유되어 있다. 특히 약리효능 측면에서 2종류인 organic acid와 phthalide가 당귀의 주요 유효성분이다. | |
당귀의 과 복용으로 인한 증상은 무엇인가? | 따라서 당귀의 고용량 및 장기 투여는 유의할 필요가 있다. 당귀의 과용량 복용은 피로, 졸음, 위장장애, 복통과 소양증 등이 관찰되는 것으로 알려졌다. 특히 당귀가 에스트로겐의 효능에 있기 때문에 유방, 자궁, 난소 등의 부위에 암을 가진 여성에게는 금물이다. | |
당귀의 ligustilide, caffeic acid, safrole 성분이 활성 중간 대사체로 전환되는 경우 생체에 어떠한 영향을 미치는가? | 독성측면에서 비교적 독성이 낮은 반수치사량이 확인되었지만 당귀의 ligustilide, caffeic acid 그리고 safrole 등의 성분은 약리작용도 하지만 활성중간대사체로 생체전환된다. 이들 활성중간대사체는 생체를 구성하는 DNA를 비롯하여 단백질, 지질 그리고 당 등 4대 거대분자와의 상호작용을 통해 독성을 유발할 수 있다. 따라서 여성과 관련된 암과 출혈이 있는 경우와 더불어 활성중간대사체 생성 측면에서 장기간 고용량의 복용은 삼가하는 것이 바람직하다. |
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