[논문]Effects of Silkworm Pupae on Bone Mineral Density in Ovariectomized Rat Model of Osteoporesis

Ryu, Kang-Sun; Lee, Heui-Sam; Kim, Kee-Young; Kim, Mi-Ja; Kang, Pil-Don

doi:10.7852/ijie.2012.24.2.063

[국내논문] Effects of Silkworm Pupae on Bone Mineral Density in Ovariectomized Rat Model of Osteoporesis 원문보기

International journal of industrial entomology, v.24 no.2, 2012년, pp.63 - 68

Ryu, Kang-Sun (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) , Lee, Heui-Sam (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) , Kim, Kee-Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) , Kim, Mi-Ja (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) , Kang, Pil-Don (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)

Abstract ▼ AI-Helper

Osteoporosis is characterized by the reduced density of mineralized bone matrix. The loss of bone has been attributed to an imbalance between bone formation and bone resorption. The silkmoth is one of the famous traditional tonic medicines. Silkworm pupa was evaluated for its antiosteoporotic activity in an ovariectomized rat model of osteoporosis. The rats were ovariectomized at 6weeks of age and divided into 7 groups. All the groups were fed without calcium diet. The OVX rats were treated with water and silkworm powder for 6 weeks. In OVX rats, the body weight, feeding and water intake quantity did not show a significant change, but the silkworm pupa powder immediately before the eclosion of Yeonrokjam was significantly increased the bone mineral density in the femoral bone. The silkworm pupa powder increased the bone with increasing calcium in serum. These results also showed its protective action through promotion of bone formation. The silkworm pupa powder has a definite antiosteoporotic effect; similar to estrogen, it is especially effective for the prevention of bone fracture induced by estrogen deficiency. The silkworm pupa powder is a promising anti-osteoporotic agent that can prevent bone fractures in osteoporotic patients. The silkworm pupa powder does not show serious side effects because natural herbal medicine origin.

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문제 정의

, 2011). The aim of this study is to evaluate the effects of silkworm pupa powder in preventing osteoporosis and ameliorating bone loss in ovariectomized rats.

제안 방법

Statistical analysis was carried out for the correlation between bone morphometry, micro–CT and BMD.
1). The bone mineral density(BMD) tests were performed on the proximal femur by using NFR polaris-G90(Nanofocusray Co.), 2-dimensional bone morphometric analysis by custom computer program, and 2D bone structure anlaysis by using micro-CT. Statistical analysis was carried out for the correlation between bone morphometry, micro–CT and BMD.

대상 데이터

Six-week-old female rats of SD-strain were purchased from SAMTAKO Bio Korea and were grown. Rats were reared 6 animals to a cage and maintained at 22℃, room temperature and 50% humidity, respectively (12 hrs of light and dark cycle) with free access to rodent diet (SAMTAKO Bio Korea) and sterilized water.
The silkworms used for the experiment were Yangwonjam and Yeonnokjam that are successively preserved as the silkworm leading variety in Korea. Yangwonjam is sex-limited silkworm bred with larval marker.

데이터처리

Statistical analysis of the data from the animal experiments in this report was performed by the one-way analysis of variance (ANOVA) followed by the Duncan test for multiple comparisons. A p value less than or equal to 0.

참고문헌 (14)

Arjmandi BH, Alekel L, Hollis BW, Amin D, Stacewicz SapuntzakisjM, Guo P (1996) Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J. Nutr 126, 161-167.

상세보기
Canalis E, McCarthy T, Centrella M (1988) Growth factors and the regulation on bone remodeling. J. Clin. Invest. 81, 277-281.

상세보기
Einhorn T(1992) Bone strength: the bottom line. Calcif. Tissue Int. 51, 333-339.

상세보기
Gao SQ, Fu DX, Zhang HM (1999) Advances in the study on the treatment of osteoporosis with Herba Epimedii and its compound prescriptions. China J. Chin. Mater. Med. 24, 249-251.
Genant HK, BayIink DJ, Gallagher JC (1998) Estrogens in the prevention of osteoporosis in postmenopausal women. Am. J. Obstet. Gynaecol. 161, 1842-1846.
Gorman C, Park A (2002) About hormones. Time July 22, 36-37.
Ke HZ, Chen HK, Simmons HA, Qi H, Crawford DT, Pirie CM, et al (1997) Comparative effects of droloxifene, tamoxifen, and estrogenon bone, serum cholesterol, and uterine histology in the ovariectomized rat model. Bone 20,31-39.

상세보기
Kelly PJ (1996) Is osteoporosis a genetically determined disease? Br. J. Obstet. Gynaecol. 103, 20-27.

상세보기
Li QN, Liao JM, Wu T, Huang LF, Liang NC (1996) Epimedium sagittatum Maxim, preventing hormone- induced osteoporosis in rats. Chin. Pharm. J. 31, 467-470.
Ma HP, Jia ZP, Ge X (2002) Studies on the theraputic effect of total flavonoids of Herba Epimedii on experimental osteoporosis in rats. Huaxi J. Pharm. 17, 163-167.
Maddox RW, Carson DS. Barnes CI (1998) Estrogen and postmenopausal women, US Pharmacist 23, 141-150.
Ryu KS, Ahn MY, Lee HS, Kim IK, Kim JW. Kim SH, Choi JH (2002) The tonic effect of the extract from male silkworm( Bombyx mori L.) pupae on rats. Int.J.Indust. Entomol. 5(1), 123-126. 2002.
Ryu KS, Lee HS, Kim KY, Kim MJ. Oh HG, Kang PD (2011) Secretion Effect of Estrogen with Sex and Growth Stage of Silkworm (Bombyx mori L.). Int.J.Indust. Entomol. 22(1), 17-20. 2011.

원문보기 상세보기
Wehren LE (2003) The epidemiology of osteoporosis and fractures in geriatric medicine. Clin. Geriatr. Med. 19, 245-258, 2003.

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