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Immune Disorders and Its Correlation with Gut Microbiome 원문보기

Immune network : official journal of the Korean association of immunobiologists, v.12 no.4, 2012년, pp.129 - 138  

Hwang, Ji-Sun (School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology (GIST)) ,  Im, Chang-Rok (Global Leader Program, Bugil Academy) ,  Im, Sin-Hyeog (School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology (GIST))

Abstract AI-Helper 아이콘AI-Helper

Allergic disorders such as atopic dermatitis and asthma are common hyper-immune disorders in industrialized countries. Along with genetic association, environmental factors and gut microbiota have been suggested as major triggering factors for the development of atopic dermatitis. Numerous studies s...

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  • Interestingly, IL-10 knockout mice spontaneously develop colitis when colonized with a conventional flora but remain disease free when maintained under germ-free conditions (83-87). These studies suggest the role of commensal flora in the development of inflammatory bowel disease. The role of probiotic strains in animal model of IBD was summarized in Table II.
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참고문헌 (89)

  1. 1 Sanders ME Probiotics: definition, sources, selection, and uses Clin Infect Dis 2008 46 Suppl 2 S58 S61 18181724 

  2. 2 Feleszko W Jaworska J Rha RD Steinhausen S Avagyan A Jaudszus A Ahrens B Groneberg DA Wahn U Hamelmann E Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma Clin Exp Allergy 2007 37 498 505 17430345 

  3. 3 Miraglia del Giudice M Jr De Luca MG Capristo C Probiotics and atopic dermatitis. A new strategy in atopic dermatitis Dig Liver Dis 2002 34 Suppl 2 S68 S71 12408445 

  4. 4 Sheil B Shanahan F O'Mahony L Probiotic effects on inflammatory bowel disease J Nutr 2007 137 3 Suppl 2 819S 824S 17311981 

  5. 5 Leung DY Boguniewicz M Howel MD Nomura I Hamid QA New insights into atopic dermatitis J Clin Invest 2004 113 651 657 14991059 

  6. 6 Leung DY Jain N Leo HL New concepts in the pathogenesis of atopic dermatitis Curr Opin Immunol 2003 15 634 638 14630196 

  7. 7 Okada H Kuhn C Feillet H Bach JF The 'hygiene hypothesis' for autoimmune and allergic diseases: an update Clin Exp Immunol 2010 160 1 9 20415844 

  8. 8 Atherton DJ Topical corticosteroids in atopic dermatitis BMJ 2003 327 942 943 14576221 

  9. 9 Jia W Li H Zhao L Nicholson JK Gut microbiota: a potential new territory for drug targeting Nat Rev Drug Discov 2008 7 123 129 18239669 

  10. 10 Bach JF The effect of infections on susceptibility to autoimmune and allergic diseases N Engl J Med 2002 347 911 920 12239261 

  11. 11 Maggi E The TH1/TH2 paradigm in allergy Immunotechnology 1998 3 233 244 9530557 

  12. 12 Rautava S Ruuskanen O Ouwehand A Salminen S Isolauri E The hygiene hypothesis of atopic disease--an extended version J Pediatr Gastroenterol Nutr 2004 38 378 388 15085015 

  13. 13 Shreiner A Huffnagle GB Noverr MC The "Microflora Hypothesis" of Allergic Disease GI Microbiota and Regulation of the Immune System 2008 Springer New York, USA 113 134 

  14. 14 Turnbaugh PJ Ley RE Hamady M Fraser-Liggett CM Knight R Gordon JI The human microbiome project Nature 2007 449 804 810 17943116 

  15. 15 Human Microbiome Jumpstart Reference Strains Consortium Nelson KE Weinstock GM Highlander SK Worley KC Creasy HH Wortman JR Rusch DB Mitreva M Sodergren E Chinwalla AT Feldgarden M Gevers D Haas BJ Madupu R Ward DV Birren BW Gibbs RA Methe B Petrosino JF Strausberg RL Sutton GG White OR Wilson RK Durkin S Giglio MG Gujja S Howarth C Kodira CD Kyrpides N Mehta T Muzny DM Pearson M Pepin K Pati A Qin X Yandava C Zeng Q Zhang L Berlin AM Chen L Hepburn TA Johnson J McCorrison J Miller J Minx P Nusbaum C Russ C Sykes SM Tomlinson CM Young S Warren WC Badger J Crabtree J Markowitz VM Orvis J Cree A Ferriera S 

  16. 16 Tlaskalová-Hogenová H Stěpánková R Kozáková H Hudcovic T Vannucci L Tučková L Rossmann P Hrnčíř T Kverka M Zákostelská Z Klimešová K Přibylová J Bártová J Sanchez D Fundová P Borovská D Srůtková D Zídek Z Schwarzer M Drastich P Funda DP The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases Cell Mol Immunol 2011 8 110 120 21278760 

  17. 17 Human Microbiome Project Consortium A framework for human microbiome research Nature 2012 486 215 221 22699610 

  18. 18 Cho I Blaser MJ The human microbiome: at the interface of health and disease Nat Rev Genet 2012 13 260 270 22411464 

  19. 19 Flohr C Pascoe D Williams HC Atopic dermatitis and the 'hygiene hypothesis': too clean to be true? Br J Dermatol 2005 152 202 216 15727630 

  20. 20 Gibbs S Surridge H Adamson R Cohen B Bentham G Reading R Atopic dermatitis and the hygiene hypothesis: a case-control study Int J Epidemiol 2004 33 199 207 15075169 

  21. 21 Kalliomäki M Kirjavainen P Eerola E Kero P Salminen S Isolauri E Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing J Allergy Clin Immunol 2001 107 129 134 11150002 

  22. 22 Penders J Thijs C van den Brandt PA Kummeling I Snijders B Stelma F Adams H van Ree R Stobberingh EE Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study Gut 2007 56 661 667 17047098 

  23. 23 Kendler M Uter W Rueffer A Shimshoni R Jecht E Comparison of fecal microflora in children with atopic eczema/dermatitis syndrome according to IgE sensitization to food Pediatr Allergy Immunol 2006 17 141 147 16618364 

  24. 24 Ouwehand AC Antiallergic effects of probiotics J Nutr 2007 137 3 Suppl 2 794S 797S 17311977 

  25. 25 Turnbaugh PJ Ley RE Mahowald MA Magrini V Mardis ER Gordon JI An obesity-associated gut microbiome with increased capacity for energy harvest Nature 2006 444 1027 1031 17183312 

  26. 26 Ley RE Turnbaugh PJ Klein S Gordon JI Microbial ecology: human gut microbes associated with obesity Nature 2006 444 1022 1023 17183309 

  27. 27 Million M Maraninchi M Henry M Armougom F Richet H Carrieri P Valero R Raccah D Vialettes B Raoult D Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii Int J Obes (Lond) 2012 36 817 825 21829158 

  28. 28 Giongo A Gano KA Crabb DB Mukherjee N Novelo LL Casella G Drew JC Ilonen J Knip M Hyöty H Veijola R Simell T Simell O Neu J Wasserfall CH Schatz D Atkinson MA Triplett EW Toward defining the autoimmune microbiome for type 1 diabetes ISME J 2011 5 82 91 20613793 

  29. 29 Ogden NS Bielory L Probiotics: a complementary approach in the treatment and prevention of pediatric atopic disease Curr Opin Allergy Clin Immunol 2005 5 179 184 15764910 

  30. 30 Guarner F Malagelada JR Gut flora in health and disease Lancet 2003 361 512 519 12583961 

  31. 31 Artis D Epithelial-cell recognition ofcommensal bacteria and maintenance of immune homeostasis in the gut Nat Rev Immunol 2008 8 411 420 18469830 

  32. 32 Macdonald TT Monteleone G Immunity, inflammation, and allergy in the gut Science 2005 307 1920 1925 15790845 

  33. 33 Kelly D Conway S Aminov R Commensal gut bacteria: mechanisms of immune modulation Trends Immunol 2005 26 326 333 15922949 

  34. 34 Coombes JL Powrie F Dendritic cells in intestinal immune regulation Nat Rev Immunol 2008 8 435 446 18500229 

  35. 35 Rescigno M Urbano M Valzasina B Francolini M Rotta G Bonasio R Granucci F Kraehenbuhl JP Ricciardi-Castagnoli P Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria Nat Immunol 2001 2 361 367 11276208 

  36. 36 Mowat AM Anatomical basis of tolerance and immunity to intestinal antigens Nat Rev Immunol 2003 3 331 341 12669023 

  37. 37 O'Hara AM Shanahan F The gut flora as a forgotten organ EMBO Rep 2006 7 688 693 16819463 

  38. 38 Sudo N Sawamura S Tanaka K Aiba Y Kubo C Koga Y The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction J Immunol 1997 159 1739 1745 9257835 

  39. 39 Ostman S Rask C Wold AE Hultkrantz S Telemo E Impaired regulatory T cell function in germ-free mice Eur J Immunol 2006 36 2336 2346 16897813 

  40. 40 Kong HH Skin microbiome: genomics-based insights into the diversity and role of skin microbes Trends Mol Med 2011 17 320 328 21376666 

  41. 41 Grice EA Kong HH Conlan S Deming CB Davis J Young AC Bouffard GG Blakesley RW Murray PR Green ED Turner ML Segre JA NISC Comparative Sequencing Program Topographical and temporal diversity of the human skin microbiome Science 2009 324 1190 1192 19478181 

  42. 42 Gallo RL Nakatsuji T Microbial symbiosis with the innate immune defense system of the skin J Invest Dermatol 2011 131 1974 1980 21697881 

  43. 43 Kong HH Oh J Deming C Conlan S Grice EA Beatson MA Nomicos E Polley EC Komarow HD Murray PR Turner ML Segre JA NISC Comparative Sequence Program Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis Genome Res 2012 22 850 859 22310478 

  44. 44 Lai Y Di Nardo A Nakatsuji T Leichtle A Yang Y Cogen AL Wu ZR Hooper LV Schmidt RR von Aulock S Radek KA Huang CM Ryan AF Gallo RL Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury Nat Med 2009 15 1377 1382 19966777 

  45. 45 Naik S Bouladoux N Wilhelm C Molloy MJ Salcedo R Kastenmuller W Deming C Quinones M Koo L Conlan S Spencer S Hall JA Dzutsev A Kong H Campbell DJ Trinchieri G Segre JA Belkaid Y Compartmentalized control of skin immunity by resident commensals Science 2012 337 1115 1119 22837383 

  46. 46 Ouwehand AC Derrien M de Vos W Tiihonen K Rautonen N Prebiotics and other microbial substrates for gut functionality Curr Opin Biotechnol 2005 16 212 217 15831389 

  47. 47 Adlerberth I Cerquetti M Poilane I Wold A Collignon A Mechanisms of Colonisation and Colonisation Resistance of the Digestive Tract Part 1: Bacteria/host Interactions Microb Ecol Health Dis 2000 2 223 239 

  48. 48 Fang H Elina T Heikki A Seppo S Modulation of humoral immune response through probiotic intake FEMS Immunol Med Microbiol 2000 29 47 52 10967260 

  49. 49 Gill HS Rutherfurd KJ Cross ML Gopal PK Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019 Am J Clin Nutr 2001 74 833 839 11722966 

  50. 50 Smits HH Engering A van der Kleij D de Jong EC Schipper K van Capel TM Zaat BA Yazdanbakhsh M Wierenga EA van Kooyk Y Kapsenberg ML Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin J Allergy Clin Immunol 2005 115 1260 1267 15940144 

  51. 51 Ueno N Fujiya M Segawa S Nata T Moriichi K Tanabe H Mizukami Y Kobayashi N Ito K Kohgo Y Heat-killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function Inflamm Bowel Dis 2011 17 2235 2250 21987297 

  52. 52 Kwon HK Lee CG So JS Chae CS Hwang JS Sahoo A Nam JH Rhee JH Hwang KC Im SH Generation of regulatory dendritic cells and CD4 + Foxp3 + T cells by probiotics administration suppresses immune disorders Proc Natl Acad Sci U S A 2010 107 2159 2164 20080669 

  53. 53 Winkler P Ghadimi D Schrezenmeir J Kraehenbuhl JP Molecular and cellular basis of microflora-host interactions J Nutr 2007 137 3 Suppl 2 756S 772S 17311973 

  54. 54 Fink LN Zeuthen LH Ferlazzo G Frøkiaer H Human antigen-presenting cells respond differently to gut-derived probiotic bacteria but mediate similar strain-dependent NK and T cell activation FEMS Immunol Med Microbiol 2007 51 535 546 17903206 

  55. 55 Young SL Simon MA Baird MA Tannock GW Bibiloni R Spencely K Lane JM Fitzharris P Crane J Town I Addo-Yobo E Murray CS Woodcock A Bifidobacterial species differentially affect expression of cell surface markers and cytokines of dendritic cells harvested from cord blood Clin Diagn Lab Immunol 2004 11 686 690 15242942 

  56. 56 Zeuthen LH Christensen HR Frøkiaer H Lactic acid bacteria inducing a weak interleukin-12 and tumor necrosis factor alpha response in human dendritic cells inhibit strongly stimulating lactic acid bacteria but act synergistically with gram-negative bacteria Clin Vaccine Immunol 2006 13 365 375 16522779 

  57. 57 Homey B Steinhoff M Ruzicka T Leung DY Cytokines and chemokines orchestrate atopic skin inflammation J Allergy Clin Immunol 2006 118 178 189 16815153 

  58. 58 Vestergaard C Kirstejn N Gesser B Mortensen JT Matsushima K Larsen CG IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells: a possible mechanism in the inflammatory reaction of atopic dermatitis J Dermatol Sci 2001 26 46 54 11323220 

  59. 59 Konur A Schulz U Eissner G Andreesen R Holler E Interferon (IFN)-gamma is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-gamma and tumour necrosis factor-alpha production Br J Dermatol 2005 152 1134 1142 15948973 

  60. 60 Pivarcsi A Homey B Chemokine networks in atopic dermatitis: traffic signals of disease Curr Allergy Asthma Rep 2005 5 284 290 15967069 

  61. 61 Trautmann A Akdis M Kleemann D Altznauer F Simon HU Graeve T Noll M Bröcker EB Blaser K Akdis CA T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis J Clin Invest 2000 106 25 35 10880045 

  62. 62 Kalliomäki M Salminen S Arvilommi H Kero P Koskinen P Isolauri E Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial Lancet 2001 357 1076 1079 11297958 

  63. 63 Abrahamsson TR Jakobsson T Böttcher MF Fredrikson M Jenmalm MC Björkstén B Oldaeus G Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial J Allergy Clin Immunol 2007 119 1174 1180 17349686 

  64. 64 Wickens K Black PN Stanley TV Mitchell E Fitzharris P Tannock GW Purdie G Crane J Probiotic Study Group A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial J Allergy Clin Immunol 2008 122 788 794 18762327 

  65. 65 Soh SE Aw M Gerez I Chong YS Rauff M Ng YP Wong HB Pai N Lee BW Shek LP Probiotic supplementation in the first 6 months of life in at risk Asian infants--effects on eczema and atopic sensitization at the age of 1 year Clin Exp Allergy 2009 39 571 578 19134020 

  66. 66 Kopp MV Hennemuth I Heinzmann A Urbanek R Randomized, double-blind, placebo-controlled trial of probiotics forprimary prevention: no clinical effects of Lactobacillus GG supplementation Pediatrics 2008 121 e850 e856 18332075 

  67. 67 Weston S Halbert A Richmond P Prescott SL Effects of probiotics on atopic dermatitis: a randomised controlled trial Arch Dis Child 2005 90 892 897 15863468 

  68. 68 Viljanen M Savilahti E Haahtela T Juntunen-Backman K Korpela R Poussa T Tuure T Kuitunen M Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial Allergy 2005 60 494 500 15727582 

  69. 69 Sistek D Kelly R Wickens K Stanley T Fitzharris P Crane J Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clin Exp Allergy 2006 36 629 633 16650048 

  70. 70 Fölster-Holst R Müller F Schnopp N Abeck D Kreiselmaier I Lenz T von Rüden U Schrezenmeir J Christophers E Weichenthal M Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis Br J Dermatol 2006 155 1256 1261 17107398 

  71. 71 Chen YS Jan RL Lin YL Chen HH Wang JY Randomized placebo-controlled trial of lactobacillus on asthmatic children with allergic rhinitis Pediatr Pulmonol 2010 45 1111 1120 20658483 

  72. 72 Sawada J Morita H Tanaka A Salminen S He F Matsuda H Ingestion of heat-treated Lactobacillus rhamnosus GG prevents development of atopic dermatitis in NC/Nga mice Clin Exp Allergy 2007 37 296 303 17250703 

  73. 73 Tanaka A Jung K Benyacoub J Prioult G Okamoto N Ohmori K Blum S Mercenier A Matsuda H Oral supplementation with Lactobacillus rhamnosus CGMCC 1.3724 prevents development of atopic dermatitis in NC/NgaTnd mice possibly by modulating local production of IFN-gamma Exp Dermatol 2009 18 1022 1027 19555432 

  74. 74 Won TJ Kim B Lim YT Song DS Park SY Park ES Lee DI Hwang KW Oral administration of Lactobacillus strains from Kimchi inhibits atopic dermatitis in NC/Nga mice J Appl Microbiol 2011 110 1195 1202 21338447 

  75. 75 Bouma G Strober W The immunological and genetic basis of inflammatory bowel disease Nat Rev Immunol 2003 3 521 533 12876555 

  76. 76 Swidsinski A Ladhoff A Pernthaler A Swidsinski S Loening-Baucke V Ortner M Weber J Hoffmann U Schreiber S Dietel M Lochs H Mucosal flora in inflammatory bowel disease Gastroenterology 2002 122 44 54 11781279 

  77. 77 Favier C Neut C Mizon C Cortot A Colombel JF Mizon J Fecal beta-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease Dig Dis Sci 1997 42 817 822 9125655 

  78. 78 Gupta P Andrew H Kirschner BS Guandalini S Is lactobacillus GG helpful in children with Crohn's disease? Results of a preliminary, open-label study J Pediatr Gastroenterol Nutr 2000 31 453 457 11045848 

  79. 79 Kruis W Fric P Stolte MS Maintenance of remission in ulcerative colitis is equally effective with Escherichia coli Nissle 1917 and with standard mesalamine Gastroenterology 2001 120 5 Suppl 1 A127 

  80. 80 Malchow HA Crohn's disease and Escherichia coli. A new approach in therapy to maintain remission of colonic Crohn's disease? J Clin Gastroenterol 1997 25 653 658 9451682 

  81. 81 Gionchetti P Rizzello F Venturi A Brigidi P Matteuzzi D Bazzocchi G Poggioli G Miglioli M Campieri M Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial Gastroenterology 2000 119 305 309 10930365 

  82. 82 Venturi A Gionchetti P Rizzello F Johansson R Zucconi E Brigidi P Matteuzzi D Campieri M Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis Aliment Pharmacol Ther 1999 13 1103 1108 10468688 

  83. 83 O'Mahony L Feeney M O'Halloran S Murphy L Kiely B Fitzgibbon J Lee G O'Sullivan G Shanahan F Collins JK Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice Aliment Pharmacol Ther 2001 15 1219 1225 11472326 

  84. 84 Sheil B MacSharry J O'Callaghan L O'Riordan A Waters A Morgan J Collins JK O'Mahony L Shanahan F Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice Clin Exp Immunol 2006 144 273 280 16634801 

  85. 85 Sheil B McCarthy J O'Mahony L Bennett MW Ryan P Fitzgibbon JJ Kiely B Collins JK Shanahan F Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis Gut 2004 53 694 700 15082588 

  86. 86 Madsen KL Doyle JS Jewell LD Tavernini MM Fedorak RN Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice Gastroenterology 1999 116 1107 1114 10220502 

  87. 87 Schultz M Veltkamp C Dieleman LA Grenther WB Wyrick PB Tonkonogy SL Sartor RB Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice Inflamm Bowel Dis 2002 8 71 80 11854603 

  88. 88 Khoruts A Sadowsky MJ Therapeutic transplantation of the distal gut microbiota Mucosal Immunol 2011 4 4 7 21150894 

  89. 89 Delzenne NM Neyrinck AM Bäckhed F Cani PD Targeting gut microbiota in obesity: effects of prebiotics and probiotics Nat Rev Endocrinol 2011 7 639 646 21826100 

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