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Sleep-Promoting Effect of Ecklonia cava: Ethanol Extract Promotes Non-rapid Eye Movement Sleep in C57BL/6N Mice 원문보기

Fisheries and aquatic sciences, v.17 no.1, 2014년, pp.19 - 25  

Yoon, Minseok (Korea Food Research Institute) ,  Kim, Jin Soo (Department of Seafood Science and Technology, Institute of Marine Industry, Gyeongsang National University) ,  Jo, Jinho (Korea Food Research Institute) ,  Han, Daeseok (Korea Food Research Institute) ,  Cho, Suengmok (Korea Food Research Institute)

Abstract AI-Helper 아이콘AI-Helper

We investigated the effects of Ecklonia cava ethanol extract (ECE) on sleep architecture and sleep profiles. ECE was orally administered at a dose of 100, 250, or 500 mg/kg to C57BL/6N mice and its effects were measured by recording electroencephalogram (EEG) and electromyogram. Administration of EC...

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제안 방법

  • , San Diego, CA, USA). The time-course of hourly amounts of sleep and Wake at each stage, histograms of the amounts of sleep and Wake, sleep latency, and mean duration of sleep and Wake were analyzed using the paired t-test, with each animal serving as its own control. For sleep latency and the total amount of each vigilance stage during the 3 h period immediately following drug treatment, one-way repeated measures analysis of variance (ANOVA) was performed, followed by the Dunnett’s test to determine whether the differences among groups were statistically significant.
  • To better understand the sleep profile caused by ECE, the mean duration of each sleep stage and EEG power density in NREMS were calculated. ECE and DZP significantly (P < 0.

대상 데이터

  • All procedures involving animals were conducted in accordance with the animal care and use guidelines of the Korea Food Research Institutional Animal Care and Use Committee (permission number: KFRI-M-12027). C57BL/6N mice (male; 27-30 g; 12 weeks old) were purchased from Koatech Animal Inc. (Pyeongtaek, Korea). Animals were housed in an insulated, sound-proof recording room maintained at an ambient temperatures of 23 ± 0.

데이터처리

  • For sleep latency and the total amount of each vigilance stage during the 3 h period immediately following drug treatment, one-way repeated measures analysis of variance (ANOVA) was performed, followed by the Dunnett’s test to determine whether the differences among groups were statistically significant.
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참고문헌 (31)

  1. Ahn G, Hwang I, Park E, Kim J, Jeon YJ, Lee J, Park JW and Jee Y. 2008. Immunomodulatory effects of an enzymatic extract from Ecklonia cava on murine splenocytes. Mar Biotechnol 10, 278-289. http://dx.doi.org/10.1007/s10126-007-9062-9. 

  2. Ahn G, Park E, Lee WW, Hyun JW, Lee KW, Shin T, Jeon YJ and Jee Y. 2011. Enzymatic extract from Ecklonia cava induces the activation of lymphocytes by IL-2 production through the classical NF- ${\kappa}B$ pathway. Mar Biotechnol 13, 66-73. http://dx.doi.org/10.1007/s10126-010-9270-6. 

  3. Bastien CH, LeBlanc M, Carrier J and Morin CM. 2003. Sleep EEG power spectra, insomnia, and chronic use of benzodiazepines. Sleep 26, 313-317. 

  4. Borja NL and Daniel KL. 2006. Ramelteon for the treatment of insomnia. Clin Ther 28, 1540-1555. http://dx.doi.org/10.1016/j.clinthera.2006.10.016. 

  5. Brand S and Kirov R. 2011. Sleep and its importance in adolescence and in common adolescent somatic and psychiatric conditions. Int J Gen Med 4, 425-442. http://dx.doi.org/10.2147/IJGM.S11557. 

  6. Cho S, Han D, Kim SB, Yoon M, Yang H, Jin YH, Jo J, Yong H, Lee SH, Jeon YJ and Shimizu M. 2012a. Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed. Biosci Biotechnol Biochem 76, 163-168. http://dx.doi.org/10.1271/bbb.110702. 

  7. Cho S, Yang H, Jeon YJ, Lee CJ, Jin YH, Baek NI, Kim D, Kang SM, Yoon M, Yong H, Shimizu M and Han D. 2012b. Phlorotannins of the edible brown seaweed Ecklonia cava Kjellman induce sleep via positive allosteric modulation of gamma-aminobutyric acid type A-benzodiazepine receptor: a novel neurological activity of seaweed polyphenols. Food Chem 132, 1133-1142. http://dx.doi.org/10.1016/j.foodchem.2011.08.040. 

  8. Cochran WT, Cooley JW, Favin DL, Helms HD, Kaenel RA, Lang WW, Maling GC Jr, Nelson DE, Rader CM and Welch PD. 1967. What is the fast Fourier transform?. Proc IEEE Inst Electr Electron Eng 55, 1664-1674. 

  9. Coenen AM and van Luijtelaar EL. 1991. Pharmacological dissociation of EEG and behavior: a basic problem in sleep-wake classification. Sleep 14, 464-465. 

  10. Doghramji K. 2006. The epidemiology and diagnosis of insomnia. Am J Manag Care 12(8 Suppl 12), S214-S220. 

  11. Erman MK. 2008. New perspectives in the diagnosis and management of insomnia. CNS Spectr 13(12 Suppl 17), 3. 

  12. Heo SJ, Park EJ, Lee KW and Jeon YJ. 2005. Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresource Technol 96, 1613-1623. http://dx.doi.org/10.1016/j.biortech.2004.07.013. 

  13. Huber R, Deboer T and Tobler I. 2000. Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: empirical data and simulations. Brain Res 857, 8-19. http://dx.doi.org/10.1016/S0006-8993(99)02248-9. 

  14. Imeri L and Opp MR. 2009. How (and why) the immune system makes us sleep. Nat Rev Neurosci 10, 199-210. http://dx.doi.org/10.1038/nrn2576. 

  15. Ishida T, Obara Y and Kamei C. 2009. Effects of some antipsychotics and a benzodiazepine hypnotic on the sleep-wake pattern in an animal model of schizophrenia. J Pharmacol Sci 111, 44-52. http://dx.doi.org/10.1254/jphs.09142FP. 

  16. Kim MM and Kim SK. 2010. Effect of phloroglucinol on oxidative stress and inflammation. Food Chem Toxicol 48, 2925-2933. http://dx.doi.org/10.1016/j.fct.2010.07.029. 

  17. Kim TH and Bae JS. 2010. Ecklonia cava extracts inhibit lipopolysaccharide induced inflammatory responses in human endothelial cells. Food Chem Toxicol 48, 1682-1687. http://dx.doi.org/10.1016/j.fct.2010.03.045. 

  18. Kohtoh S, Taguchi Y, Matsumoto N, Wada M, Huang ZL and Urade Y. 2008. Algorithm for sleep scoring in experimental animals based on fast Fourier transform power spectrum analysis of the electroencephalogram. Sleep Biol Rhythms 6, 163-171. http://dx.doi.org/10.1111/j.1479-8425.2008.00355.x. 

  19. Kong CS, Kim JA, Yoon NY and Kim SK. 2009. Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells. Food Chem Toxicol 47, 1653-1658. http://dx.doi.org/10.1016/j.fct.2009.04.013. 

  20. Krueger JM, Rector DM, Roy S, Van Dongen HPA, Belenky G and Panksepp J. 2008. Sleep as a fundamental property of neuronal assemblies. Nat Rev Neurosci 9, 910-919. http://dx.doi.org/10.1038/nrn2521. 

  21. Le QT, Li Y, Qian ZJ, Kim MM and Kim SK. 2009. Inhibitory effects of polyphenols isolated from marine alga Ecklonia cava on histamine release. Process Biochem 44, 168-176. http://dx.doi.org/10.1016/j.procbio.2008.10.002. 

  22. Lee H, Kang C, Jung ES, Kim JS and Kim E. 2011. Antimetastatic activity of polyphenol-rich extract of Ecklonia cava through the inhibition of the Akt pathway in A549 human lung cancer cells. Food Chem 127, 1229-1236. 

  23. Li Y, Qian ZJ, Ryu BM, Lee SH, Kim MM and Kim SK. 2009. Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava. Bioorg Med Chem 17, 1963-1973. 

  24. Masaki M, Aritake K, Tanaka H, Shoyama Y, Huang ZL and Urade Y. 2012. Crocin promotes non-rapid eye movement sleep in mice. Mol Nutr Food Res 56, 304-308. 

  25. Meletis CD and Zabriskie N. 2008. Natural approaches for optimal sleep. Alternat Complement Ther 14, 181-188. 

  26. Qiu MH, Qu WM, Xu XH, Yan MM, Urade Y and Huang ZL. 2009. $D_1/D_2$ receptor-targeting L-stepholidine, an active ingredient of the Chinese herb Stephonia, induces non-rapid eye movement sleep in mice. Pharmacol Biochem Be 94, 16-23. 

  27. Qu WM, Xu XH, Yan MM, Wang YQ, Urade Y and Huang ZL. 2010. Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice. J Neurosci 30, 4382-4389. 

  28. Shim SY, Quang-To L, Lee SH and Kim SK. 2009. Ecklonia cava extract suppresses the high-affinity IgE receptor, $Fc{\varepsilon}RI$ expression. Food Chem Toxicol 47, 555-560. 

  29. Tobler I, Kopp C, Deboer T and Rudolph U. 2001. Diazepam-induced changes in sleep: Role of the ${\alpha}1\;GABA_A$ receptor subtype. Proc Natl Acad Sci USA 98, 6464-6469. 

  30. van Lier H, Drinkenburg WH, van Eeten YJ and Coenen AM. 2004. Effects of diazepam and zolpidem on EEG beta frequencies are behavior-specific in rats. Neuropharmacology 47, 163-174. 

  31. Winsky-Sommerer R. 2009. Role of $GABA_A$ receptors in the physiology and pharmacology of sleep. Eur J Neurosci 29, 1779-1794. 

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