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Phlorotannins of the edible brown seaweed Ecklonia cava Kjellman induce sleep via positive allosteric modulation of gamma-aminobutyric acid type A-benzodiazepine receptor: A novel neurological activity of seaweed polyphenols

Food chemistry, v.132 no.3, 2012년, pp.1133 - 1142  

Cho, S. (Department of Applied Biological Chemistry, The University of Tokyo, Tokyo 113-8657, Japan) ,  Yang, H. ,  Jeon, Y.J. ,  Lee, C.J. ,  Jin, Y.H. ,  Baek, N.I. ,  Kim, D. ,  Kang, S.M. ,  Yoon, M. ,  Yong, H. ,  Shimizu, M. ,  Han, D.

Abstract AI-Helper 아이콘AI-Helper

The primary objective was to investigate whether seaweeds have hypnotic activity. Methanol extracts of 30 seaweeds were screened for their binding activity at the GABA type A-benzodiazepine (GABAA-BZD) receptor, a well-characterised molecular target for sedative-hypnotics. The most active ...

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