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NTIS 바로가기Journal of nutrition and health, v.48 no.6, 2015년, pp.468 - 475
신유경 (경희대학교 생활과학대학 식품영양학과) , 최지원 (경희대학교 생활과학대학 식품영양학과) , 오세영 (경희대학교 생활과학대학 식품영양학과) , 정자용 (경희대학교 생활과학대학 식품영양학과)
Purpose: Genetic polymorphisms in antioxidant defense and detoxification genes may modulate the levels of oxidative stress biomarkers. Methods: A total of 301 healthy preschool-aged children in the Seoul and Kyung-gi areas were recruited. DNA was extracted from blood for genotyping of manganese supe...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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활성산소는 어떻게 생성되는가? | 활성산소는 산소의 체내 대사과정과 더불어 흡연, 환경오염 등의 외부 자극으로 인하여 생성된다. 활성산소의 일부는 체내에서 매우 중요한 역할을 하기도 하지만 대부분은 항산화 방어기전에 의해 제거되며, 생리적으로 정상적인 상태에서는 활성산소 생성과 항산화 체계에 의한 제거작용이 균형을 이루고 있다. | |
간접흡연에의 노출은 산화스트레스 증가의 주요 요인이 될 수 있는 이유는? | 간접흡연에의 노출은 산화스트레스 증가의 주요 요인이 될 수 있다. 앞에서 살펴본 Mn-SOD와 GST 유전자 다형성과 체내 산화손상지표 간의 관계가 간접흡연에의 노출 여부에 따라 달라지는지 알아보기 위하여, 이들 유전자 다형성과 간접흡연과의 상호작용이 체내 산화손상지표에 미치는 영향을 분석하였다. 그 결과, 간접흡연에의 노출 여부는 소변의 8-OHdG 수준에 유의한 영향을 주지 않았으며, 각 유전자 다형성과 간접흡연 간의 유의적인 상호작용도 나타나지 않았다 (Fig. 1). 또한, 간접 흡연 노출군과 비노출군의 유전자 다형성에 따른 혈중 MDA 농도에는 유의적인 차이가 없었다 (자료 미제시). | |
산화 스트레스란? | 활성산소의 일부는 체내에서 매우 중요한 역할을 하기도 하지만 대부분은 항산화 방어기전에 의해 제거되며, 생리적으로 정상적인 상태에서는 활성산소 생성과 항산화 체계에 의한 제거작용이 균형을 이루고 있다. 1 산화 스트레스는 체내 활성산소가 비정상적으로 과다하게 축적되어 있는 상태로, 산화 스트레스의 증가는 세포 내 DNA, 지질, 단백질 등의 파괴를 유도하여 노화는 물론 암을 비롯하여, 심혈관계 질환, 뇌 질환, 염증성 질환 등 다양한 질병의 발생에 관여한다. 2-7활성산소에 의한 산화적 손상을 억제하기 위한 체내 항산화 방어 체계는 항산화 영양소와 항산화 효소의 작용으로 이루어지는데 이러한 항산화 능력은 개개인에 따라 다르며 유전적 요인이 함께 관여하는 것으로 생각되고 있어 이에 대한 연구가 필요하다. |
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