선택한 단어 수는 입니다.
최소 단어 이상 선택하여야 합니다.
최소 단어 이상 선택하여야 합니다.
선택한 단어 수는 30입니다.
최대 10 단어까지만 선택 가능합니다.
최대 10 단어까지만 선택 가능합니다.
제안 방법
- Further, although there are many choline acetyltransferase agonists and acetylcholinesterase (AChE) inhibitors for memory enhancement, they are ineffective and controversial due to their serious side effects and toxicity. For this reason, research has tried to identify memory enhancers from natural materials (5,6).
- lucidum water extracts can be used as functional ingredients to improve memory. In this study, FGWB was secondarily fermented with lactic acid bacteria separated from kimchi in Imsil in order to resolve polymer polysaccharides from G. lucidum water extracts into less differentiated polysaccharides and obtain functional ingredients, including polysaccharides, triterpenes, alkaloid, and diverse vitamins (28). Therefore, FGWB and FGWBL improve scopolamine-induced memory and cognitive function by preventing brain cell death or by stimulating secretion of memory-related neurotransmitters such as acetylcholine and glutamate.
- The passive avoidance test was performed to determine the efficacy of fermented G. lucidum water extracts in improving short-term memory despite scopolamine-induced memory and cognitive impairment (Fig. 4). The scopolamine group (131.
- The rotarod test and the vertical pole test were carried out to determine the efficacy of fermented G. lucidum water extracts in improving scopolamine-induced motor coordination and behavioral disorders (Fig. 5). Most degenerative diseases such as memory impairment and dementia are accompanied by reduction of motor ability, including sense of balance and coordination (29).
- The passive avoidance test is a well-established experimental procedure used to assess short-term reference memory, which is dependent on cortical and hippocampal circuitries (22,23). The step-through passive avoidance test was performed in identical illuminated and dark chambers (Gemini Avoidance System, San Diego, CA, USA). The illuminated compartment contained a bulb, and the floor of the non-illuminated compartment was composed of stainless steel rods.
- This study examined fermentation by lactic acid bacteria as a method to improve the memory-enhancing effects as well as maximize the efficacy of G. lucidum water extracts by two-step fermentation with Bifidobacterium bifidum and Lactobacillus sakei. Morris water maze test and passive avoidance test were performed using scopolamine-induced memory-impaired animals, and behavioral changes and hippocampal AChE activities were measured.
대상 데이터
- The pool was filled with water maintained at 21±2oC. The tank was placed in a dimly lit, sound proof test room with various visual cues. The pool was conceptually divided into quadrants.
데이터처리
- Data were expressed as mean±SD (standard deviation), and statistical significance was analyzed using Student's t-test and one-way analysis of variance (ANOVA), followed by the least significant difference (LSD) post hoc test using SPSS for windows version 17.0 (SPSS Inc., Chicago, IL, USA).
- Statistical significance was tested by unpaired Student's t-test.
이론/모형
- To assess the equilibrium function, the vertical pole test was carried out according to the method of Ogawa et al. (24). Rats were placed on a vertical pole and the fall time from the pole was measured.
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