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논문 상세정보

Abstract

This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine- induced memory impairment in rats. GW were fermented by the lactic acid bacterium Bifidobacterium bifidum (FGWB), followed by Lactobacillus sakei LI033 (FGWBL). To induce amnesia, scopolamine (1 mg/kg) was intraperitoneally injected into rats 30 min before the behavioral tests. Step-through latencies of rats treated with primary fermented extracts (300 mg/kg, FGWB) and secondary fermented extracts (300 mg/kg, FGWBL) were significantly longer than those of rats treated with GW (300 mg/kg) in the retention trial of the multiple trial passive avoidance test. In the Morris water maze task, FGWBL significantly shortened escape latencies in training trials. Furthermore, swimming times within the target zone during the probe trial with FGWBL were significantly higher than the GW and FGWB treatments. In addition, acetylcholinesterase activities were lower in the brains of scopolamine-treated rats treated with FGWBL. These results suggest that FGWBL could be useful to enhance learning memory and cognitive function via cholinergic dysfunction.

참고문헌 (37)

  1. Lee GJ, Lee KL, Yang S, Jun WH. 2008. Quality of life and the associated factors in dementia. J Korean Acad Psychiatr Ment Health Nurs 17: 273-280. 
  2. Anderson L, McConnell SR. 2007. Cognitive health: an emerging public health issue. Alzheimers Dement 3: S70-S73. 
  3. Xu Z, Li H, Jin P. 2012. Epigenetics-based therapeutics for neurodegenerative disorders. Curr Transl Geriatr Exp Gerontol Rep 1: 229-236. 
  4. Akaike A, Takada-Takatori Y, Kume T, Izumi Y. 2010. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of ${\alpha}$4 and ${\alpha}$7 receptors in neuroprotection. J Mol Neurosci 40: 211-216. 
  5. Lee SE, Shim IS, Kim GS, Yim SV, Park HJ, Shim HS, Ye MS, Kim SY. 2011. The neuroprotective effect of white ginseng (Panax ginseng C. A. Meyer) on the trimethyltin (TMT)- induced memory deficit rats. Korean J Medicinal Crop Sci 19: 456-463. 
  6. Shi DH, Yan ZQ, Zhang LN, Wang YR, Jiang CP, Wu JH. 2012. A novel 7-O-modified genistein derivative with acetylcholinesterase inhibitory effect, estrogenic activity and neuroprotective effect. Arch Pharm Res 35: 1645-1654. 
  7. Tanabe F, Miyasaka N, Kubota T, Aso T. 2004. Estrogen and progesterone improve scopolamine-induced impairment of spatial memory. J Med Dent Sci 51: 89-98. 
  8. Boh B, Berovic M, Zhang J, Zhi-Bin L. 2007. Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev 13: 265-301. 
  9. Liu GQ, Xiao HX, Wang XL, Zhao Y, Zhang YG, Ren GP. 2011. Stimulated production of triterpenoids of Ganoderma lucidum by an ether extract from the medicinal insect, Catharsius molossus, and identification of the key stimulating active components. Appl Biochem Biotechnol 165: 87-97. 
  10. Shiao MS. 2003. Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions. Chem Rec 3: 172-180. 
  11. Chan GC, Chan WK, Sze DM. 2009. The effects of ${\beta}$-glucan on human immune and cancer cells. J Hematol Oncol 2: 25. 
  12. Hu H, Ahn NS, Yang X, Lee YS, Kang KS. 2002. Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int J Cancer 102: 250-253. 
  13. Cheung WWM, Hui WS, Chu PWK, Chiu SW, Ip NY. 2000. Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett 486: 291-296. 
  14. Zhou Y, Qu ZQ, Zeng YS, Lin YK, Li Y, Chung P, Wong R, Hagg U. 2012. Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus. Exp Toxicol Pathol 64: 673-680. 
  15. Park YS, Chang HG. 2003. Lactic acid fermentation and biological activities of Rubus coreanus. J Korean Soc Agric Chem Biotechnol 46: 367-375. 
  16. Kannan N, Aravindan R. 2009. Effect of fermentation parameters on extra cellular tannase production by Lactobacillus plantarum MTCC 1407. E-J Chem 6: 979-984. 
  17. Hubert J, Berger M, Nepveu F, Paul F, Dayde J. 2008. Effects of fermentation on the phytochemical composition and antioxidant properties of soy germ. Food Chem 109: 709-721. 
  18. Yang HS, Choi YJ, Oh HH, Moon JS, Jung HK, Kim KJ, Choi BS, Lee JW, Huh CK. 2014. Antioxidative activity of mushroom water extracts fermented by lactic acid bacteria. J Korean Soc Food Sci Nutr 43: 80-85. 
  19. Choi HN, Oh HH, Yang HS, Huh CK, Bae IH, Lee JS, Jeong YS, Jeong EJ, Jung HK. 2013. Antifungal activity against cheese fungi by lactic acid bacteria isolated from kimchi. Korean J Food Preserv 20: 727-734. 
  20. Morris R. 1984. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11: 47-60. 
  21. Kang SJ, Woo JH, Kim AJ. 2013. The effects of Korean ginseng on memory loss in a rat models. J Korean Soc Food Sci Nutr 42: 1190-1196. 
  22. Kim MJ, Choi SJ, Lim ST, Kim HK, Kim YJ, Yoon HG, Shin DH. 2008. Zeatin supplement improves scopolamine-induced memory impairment in mice. Biosci Biotechnol Biochem 72: 577-581. 
  23. LeDoux JE. 1993. Emotional memory: in search of systems and synapses. Ann NY Acad Sci 702: 149-157. 
  24. Ogawa N, Hirose Y, Ohara S, Ono T, Watanabe Y. 1985. A simple quantitative bradykinesia test in MPTP-treated mice. Res Commun Chem Pathol Pharmacol 50: 435-441. 
  25. Ellman GL, Courtney KD, Andres V Jr, Featherstone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88-95. 
  26. Yoo JK, Choi SJ, Kang JK, Han SS. 1999. Effects of Ganoderma lucidum extract on memory and oxidative stress of senescence- accelerated mouse. Korean J Life Science 9: 548-555. 
  27. Yuan DJ, Zhang YF, Yao CX. 2011. Effects of Ganoderma lucidum polysaccharides on synapsis and hippocampal synaptophysin expression in Alzheimer's rats model. Chin J Exp Tradit Med Formulae 17: 151-155. 
  28. Lee SC, Im NK, Jeong HY, Choi EH, Jeon SM, Jeong GS. 2014. Neuroprotective effects of ethanol extract of Ganoderma lucidum L. on murine hippocampal cells. Kor J Pharmacogn 45: 161-167. 
  29. Poorheidari G, Stanhope KJ, Pratt JA. 1998. Effects of the potassium channel blockers, apamin and 4-aminopyridine, on scopolamine-induced deficits in the delayed matching to position task in rats: a comparison with the cholinesterase inhibitor E2020. Psychopharmacology (Berl) 135: 242-255. 
  30. Whishaw IQ, Li K, Whishw PA, Gorny B, Metz GA. 2008. Use of rotorod as a method for the qualitative analysis of walking in rat. J Vis Exp 22: e1030. 
  31. Zhu WW, Liu Z, Xu HW, Chu WZ, Ye QY, Xie AM, Chen L, Li JR. 2005. Effect of the oil from ganoderma lucidum spores on pathological changes in the substantia nigra and behaviors of MPTP-treated mice. Di Yi Jun Yi Da Xue Xue Bao 25: 667-671. 
  32. Talesa VN. 2001. Acetylcholinesterase in Alzheimer's disease. Mech Ageing Dev 122: 1961-1969. 
  33. Terry AV Jr, Buccafusco JJ. 2003. The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development. J Pharmacol Exp Ther 306: 821-827. 
  34. Wang R, Yan H, Tang XC. 2006. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin 27: 1-26. 
  35. Lee IS, Ahn BR, Choi JS, Hattori M, Min BS, Bae KH. 2011. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorg Med Chem Lett 21: 6603-6607. 
  36. Zhang Y, Luo J, Huang NH, Zhang XY. 2012. Influence of Ganoderma lucidum triterpenoids on learning memory function and ACh content in Alzheimer disease model rat. Chin J Exp Tradit Med Formulae 16: 172-175. 
  37. Zhang W, Zhang Q, Deng W, Li Y, Xing G, Shi X, Du Y. 2014. Neuroprotective effect of pretreatment with Ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus. Neural Regen Res 9: 1446-1452. 

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