최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기한국식품과학회지 = Korean journal of food science and technology, v.48 no.6, 2016년, pp.597 - 603
이아름 (대구한의대학교 한의과대학 본초약리학 교실) , 권오준 (경북지역산업평가단) , 노정숙 (동명대학교 식품영양학과) , 노성수 (대구한의대학교 한의과대학 본초약리학 교실)
This study aimed to explore the protective effect of Gastrodia elata (GE) in an HCl/ethanol induced acute gastritis model by differing the steaming time. The samples GE1 (GE by steaming for 1 time) and GE9 (GE by steaming for 9 times), were selected based on the results of HPLC analysis, free radica...
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
위염이란? | 위염은 위 점막 염증성 질환을 총칭하는 것으로 위 점막을 보호하는 고유의 방어인자와 손상시키는 공격인자 사이의 균형이 깨져, 공격인자가 강해지거나 방어인자가 약해지면 발생하게 된다(1). 히스타민(Histamine), 위산, 헬리코박터 필로리(Helicobacter pylori) 감염, 비스테로이드성 소염 진통제(non-steroidal anti-inflammatory drugs, NSAIDs) 과다복용과 불규칙한 식습관, 음주, 스트레스 등이 대표적인 공격인자이다(2). | |
위염은 어떤 경우에 발생되는가? | 위염은 위 점막 염증성 질환을 총칭하는 것으로 위 점막을 보호하는 고유의 방어인자와 손상시키는 공격인자 사이의 균형이 깨져, 공격인자가 강해지거나 방어인자가 약해지면 발생하게 된다(1). 히스타민(Histamine), 위산, 헬리코박터 필로리(Helicobacter pylori) 감염, 비스테로이드성 소염 진통제(non-steroidal anti-inflammatory drugs, NSAIDs) 과다복용과 불규칙한 식습관, 음주, 스트레스 등이 대표적인 공격인자이다(2). | |
위 점막을 손상시키는 대표적인 공격인자는? | 위염은 위 점막 염증성 질환을 총칭하는 것으로 위 점막을 보호하는 고유의 방어인자와 손상시키는 공격인자 사이의 균형이 깨져, 공격인자가 강해지거나 방어인자가 약해지면 발생하게 된다(1). 히스타민(Histamine), 위산, 헬리코박터 필로리(Helicobacter pylori) 감염, 비스테로이드성 소염 진통제(non-steroidal anti-inflammatory drugs, NSAIDs) 과다복용과 불규칙한 식습관, 음주, 스트레스 등이 대표적인 공격인자이다(2). 이때, 위 점막 보호물질의 감소 또는 산화적 스트레스, 히스타민 분비량 증가 등은 위 손상과 염증을 악화시킨다. |
Banks WJ. Applied veterinary histology 2nd. pp.393-396. William & Wilkins Baltimore. Philadelphia, USA. (1986)
Shay J, Komarov SA, Fels SS, Merance D, Gruenstein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rats. Gastroenterology 5: 43-61 (1945)
Suzuki H, Nishizawa T, Tsugawa H, Mogami S, Hibi T. Role of oxidative stress in stomach disorders. J. Clin. Biochem. Nutr. 50: 35-39 (2012)
Thomson A, Hemphill D, Jeejeebhoy KN. Oxidative stress and anti-oxidants in intestinal disease. Dig. Dis. 16: 152-158 (1998)
Feldman M, Burton ME. $Histamine_2$ -receptor antagonists-standard therapy for acid-peptic diseases. N. Engl. J. Med. 20: 1672-1680 (1990)
Bell NJ, Hunt RH. Progress with proton pump inhibition. Yale J. Biol. Med. 65: 649-657 (1992)
Berardi RR, Savitsky ME, Nostrant TT. Maintenance therapy for prevention of recurrent peptic ulcers. Drug Intell. Clin. Pharm. 21: 493-507 (1987)
Fullarton GM, McLauchlan G, Macdonald A, Crean GP, McColl KE. Rebound nocturnal hypersecretion after four weeks treatment with an $H_2$ receptor antagonist. Gut 30: 449-454 (1989)
Szabo S, Bynum TE. Alternatives to the acid-oriented approach to ulcer disease: does 'cytoprotection' exist in man? A new classification of antiulcer agents. Scand. J. Gastroenterol. 23: 1-6 (1988)
Taguchi H, Yosioka I, Yamasaki K, Kim IH. Studies on the constituents Gastrodia elata Blume. Chem. Pharm. Bull. 29: 55-62 (1981)
Ahn DK, Kim HC. Hanyakpojaehak. Iljung Publishing House, Seoul, Korea. pp. 285-287 (2000)
Heo JC, Park JY, An SM, Lee JM , Yun CY, Shin HM, Kwon TK, Lee SH. Anti-oxidant and anti-tumor activities of crude extracts by Gastrodia elata Blume. Korean J. Food Preserv. 13: 83-87 (2006)
Kang TS, Kong JY, Kwon HJ, Choi, Hong JG, Park YK. A Studies on the chemical composition and in vitro biological activities of hot water extracts of Gastrodia elata. Korean J. Mycol. 30: 136-141 (2004)
Cho HE, Choi YH, Park SH, Park YS, Ahn BY. Effect of Gastrodiae rhizoma powder on serum and liver lipid levels of rats with high fat diet. Korean J. Food Nutr. 21: 64-70 (2008)
Blosis MS. Antioxidant determinations by the use of a stable free radical. Nature 26: 1199-1200 (1958)
Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Bio. Med. 26: 1231-1237 (1999)
Folin O, Denis W. On phosphotungastic-phosphomolybdic compounds as color reagent. J. Biol. Chem. 12: 239-243 (1912)
Lister CE, Lancaster JE, Sutton KH, Walker JR. Developmental changes in the concentration and composition of flavonoids in skin of a red and a green apple cultivar. J. Sci. Food Agr. 64: 155-161 (1994)
Martins JLR, Rodrigues ORL, da Silva DM, Galdino PM, de Palula JR, Romao W, da Costa HB, Vaz BG, Ghedini PC, Costa EA. Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) Sargent on gastric lesions in mice. J. Ethnopharmacol. 155: 1616-1624 (2014)
Ali SF, LeBel CP, Bondy SC. Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicology 13: 637-648 (1992)
Kooy NW, Royall JA, Ischiropoulos H, Beckman JS. Peroxynitrite-mediated oxidation of dihydrohodamine 123. Free Radic. Biol. Med. 16:149-156 (1994)
Zhao S, Li N, Zhen Y, Ge M, Li Y, Yu B, Shao RG. Protective effect of gastrodin on bile duct ligation-induced hepatic fibrosis in rats. Food Chem. Toxicol. 86: 202-207 (2015)
Zhang JS, Zhou SF, Wang Q, Guo JN, Liang HM, Deng JB, He WY. Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2 ${\alpha}$ pathway in Alzheimer's disease. Neuroscience 325: 1-9 (2016)
Kam KY, Yu SJ, Jeong N, Hong JH, Jalin AMA, Lee S, Kang SG. p-Hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia. Mol. Cells. 31: 209-215 (2011)
Liu SH, Pan IH, Chu IM. Inhibitory effect of p-hydroxybenzyl alcohol on tyrosinase activity and melanogenesis. Biol. Pharm. Bull. 30: 1135-1139 (2007)
Shin SL, Lee CH. Antioxidant effects of the methanol extracts obtained from aerial part and rhizomes of ferns native to Korea. Korean J. Plant Res. 23: 38-46 (2010)
Jeon HY, Kim MH, Kim MR. Antioxidative and antimutagenin activity of ethanol extracts from Cuscutae semen. Korean J. Food Cook. Sci. 24: 46-51 (2008)
Ishii Y, Fujii Y, Homma M. Gastric acid stimulating action of cysteamine in the rat. Eur. J. Pharmacol. 36: 331-336 (1976)
Kim SJ, Baek JY, Park CK, Kim GW. Gastroprotective effect of Korean rice-wine (Yakju). Korean J. Food Sci. Technol. 36: 818-822 (2004)
Jung KW. Momordicae cochichinensis seed extract as a therapeutic agent for acute & chronic gastritis and its constituents. PhD thesis, Seoul national University, Seoul, Korea (2012)
Kenter M, Demir H, Karakaya C, Ozbek H. Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats. World J. Gastoenterol. 11: 6662-6666 (2005)
Alrashdi AS, Salama SM, Alkiyumi SS, Abdulla MA, Hadi AHA, Abdelwahab SI, Asykin N. Mechanisms of gastroprotective effects of ethanolic leaf extract of Jasminum sambac against HCl/ethanol-induced gastric mucosal injury in rats. Evid.-Based Compl. Alt. 2012: 786426 (2012)
Boligon AA, de Freitas RB, de Brum TF, Waczuk EP, Klimaczewski CV, de Avila DS, de Freitas Bauermann L. Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats. Acta Pharm. Sin. B. 4: 358-367 (2014)
Bilici D, Suleyman H, Banoglu ZN, Kizltunc A, Avci B, Clftcioglu A, Bilici S. Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. Dig. Dis. Sci. 47: 856-861 (2002)
Suzuki Y, Ishihara M, Segami T, Ito M. Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats. Jpn. J. Pharmacol. 78: 435-441 (1998)
Atsushi O, Kenjirou O, Mamoru K, Hideaki H. Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. BMC Complem. Altern. M. 10:10.1186/1472-6882-10-45 (2010)
Van Antwerp DJ, Martin SJ, Verma IM, Green DR. Inhibition of TNF- ${\alpha}$ induced apoptosis by NF- ${\kappa}B$ . Trends Cell Biol. 8: 107-111 (1998)
Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest 117: 1162-1172 (2000)
Lee SW, Shin SM, Kim HY, Han SH, Kim KH, Kwon JH, Kwak JH, Lee CK, Yim DS, Kim KJ. Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF- ${\kappa}B$ pathways. J. Inflamm. 8: 10.1186/1476-9255-8-16 (2011)
Ekmekcioglu S, Ellerhorst J, Smid CM, Prieto VG, Munsell M, Buzaid AC, Grimm EA. Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival. Clin. Cancer Res. 6: 4768-4775 (2000)
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.