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NTIS 바로가기Journal of applied biological chemistry, v.59 no.4, 2016년, pp.365 - 372
이주영 (College of Korean Medicine, Daegu Haany University) , 권오준 (Gyeongbuk Regional Industry Evaluation, Daegyeong Institute for Regional Program Evaluation) , 노정숙 (Department of Food Science & Nutrition, Tongmyong University) , 노성수 (College of Korean Medicine, Daegu Haany University)
The objective of the present study was to evaluate the protective effect of red ginseng (RG) according to steaming time on 150 mM HCl/60 % ethanol induced gastric ulcer models in mice. The sample was divided into 3 groups-G (dried ginseng), RG 4 (steamed 4 h and dried ginseng), RG 6 (steamed 6 h and...
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실험동물은 군당 6마리씩 5그룹으로 나누어 실험을 진행하였다. 급성 위염 유발 전 24시간 동안 절식하였으며 물은 제공하였다.
핵심어 | 질문 | 논문에서 추출한 답변 |
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활성산소종으로 생겨난 산화적 스트레스는 어떻게 방어될 수 있는가? | ROS의 축적으로 인해 위 점막의 세포손상이 시작되며 염증반응의 전사인자인 inducible nitric oxide synthase (iNOS)와 cyclooxygenase-2 (COX-2)를 발현시켜 염증반응을 일어나게 한다(Hogg 등, 1992; HernandezMunoz 등, 2000; Kojima 등, 2000; Guo 등, 2006; Shen과 Tergaonkar 2009). ROS의 형성으로 인한 산화적 스트레스는 생체 내의 방어기작인 항산화 효소에 의하여 억제되지만 폴리페놀 화합물과 비타민 E, C, 플라보노이드 등과 같은 식이 항산화 성분의 섭취에 의해서도 효과적으로 방어될 수 있다(La Casa 등, 2000). | |
위염이란 무엇인가? | 위염은 위 점막에 생기는 염증성 질환을 통틀어 이르는 용어로, 한번 생긴 위염은 만성으로 발전하기 쉽다. 위벽은 4개의 층으로 이루어져 있는데, 첫 번째 층인 위 점막만 손상된 경우를 보통 위염이라고 하고, 두 번째 층 이상이 손상되어 점막하층까지 드러난 경우를 위궤양이라고 한다(Banks 1986). | |
활성산소종이 과잉 발생하면 생체에 어떤 영향을 주는가? | 인체의 생명유지에 필요한 에너지를 생성하는 호흡과정에서 체내로 공급된 산소 중 일부는 활성산소종(reactive oxygen species, ROS) 으로 전환된다(Droge 2001). 생체는 활성산소종으로부터 세포를 보호하기 위한 항산화 시스템을 가지고 있어 정상적인 상태에 서는 산화 작용이 해로운 영향을 주지 않지만 활성산소종이 과잉 생산될 경우, 산화적 스트레스가 발생하며 이로 인해 체내 항산화 체계의 균형이 깨져 여러 질환이 발병하는 것으로 알려져 있다(Halliwell 등, 1995). ROS의 축적으로 인해 위 점막의 세포손상이 시작되며 염증반응의 전사인자인 inducible nitric oxide synthase (iNOS)와 cyclooxygenase-2 (COX-2)를 발현시켜 염증반응을 일어나게 한다(Hogg 등, 1992; HernandezMunoz 등, 2000; Kojima 등, 2000; Guo 등, 2006; Shen과 Tergaonkar 2009). |
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