기미는 몇몇의 병인학적 요인을 갖고 있지만, 많은 연구가 멜라닌 형성에 집중되어 있다. 본 연구에서는 멜라닌 형성과 구별되는 혈관의 감소에 의한 기미의 개선을 보고자 하였다. 피부과 전문의의 육안평가를 통해 기미와 일광 흑자를 가진 한국 여성 20명을 대상으로 실험을 진행하였다. 연구 대상자는 8주 간 기능성 화장품을 사용하였다. Chromameter 기기로 측정한 연구 대상자의 기미 병변, 일광 흑자 병변 및 정상 피부 부위에서의 각 피부색 측정 결과를 분석하였다. 시료 사용 8주 경과 후, 기미 병변 부위의 피부색 밝기와 적색도가 정상 피부 부위에 비해 통계적으로 유의하게 개선되었다. 또한, 기미 병변 및 일광 흑자 병변 부위의 피부색 밝기의 개선 정도는 유사하였다. 그러나, 시료 사용 8주 경과 후 기미 병변 부위의 적색도가 일광 흑자 병변 부위에 비해 통계적으로 유의하게 개선되었다. 본 연구에서는 기능성 제품을 사용함으로써 기미 병변 부위에서 피부색 밝기 뿐만 아니라 적색도 또한 개선됨을 확인하였다. 이에 적색도가 기미 병변 부위의 평가를 위한 부가적이고 적합한 요인이 될 수 있음을 제시하고자 한다.
기미는 몇몇의 병인학적 요인을 갖고 있지만, 많은 연구가 멜라닌 형성에 집중되어 있다. 본 연구에서는 멜라닌 형성과 구별되는 혈관의 감소에 의한 기미의 개선을 보고자 하였다. 피부과 전문의의 육안평가를 통해 기미와 일광 흑자를 가진 한국 여성 20명을 대상으로 실험을 진행하였다. 연구 대상자는 8주 간 기능성 화장품을 사용하였다. Chromameter 기기로 측정한 연구 대상자의 기미 병변, 일광 흑자 병변 및 정상 피부 부위에서의 각 피부색 측정 결과를 분석하였다. 시료 사용 8주 경과 후, 기미 병변 부위의 피부색 밝기와 적색도가 정상 피부 부위에 비해 통계적으로 유의하게 개선되었다. 또한, 기미 병변 및 일광 흑자 병변 부위의 피부색 밝기의 개선 정도는 유사하였다. 그러나, 시료 사용 8주 경과 후 기미 병변 부위의 적색도가 일광 흑자 병변 부위에 비해 통계적으로 유의하게 개선되었다. 본 연구에서는 기능성 제품을 사용함으로써 기미 병변 부위에서 피부색 밝기 뿐만 아니라 적색도 또한 개선됨을 확인하였다. 이에 적색도가 기미 병변 부위의 평가를 위한 부가적이고 적합한 요인이 될 수 있음을 제시하고자 한다.
Melasma has several well-recognized etiologic factors, but most researches focus on melanogenesis. The purpose of this study is to show improvement of melasma by reducing vascularity distinguished from melanogenesis. We examined 20 Korean women with both melasma and solar lentigo that were visually ...
Melasma has several well-recognized etiologic factors, but most researches focus on melanogenesis. The purpose of this study is to show improvement of melasma by reducing vascularity distinguished from melanogenesis. We examined 20 Korean women with both melasma and solar lentigo that were visually assessed by a dermatologist. The volunteers applied functional cosmetics for 8 weeks. We analyzed the results obtained using the chromameter, evaluating the skin color of three areas (melasma lesions, solar lentigo lesions, and non-lesional skin) on the face of volunteer. There was a statistically significant improvement in the brightness and redness of melasma lesions compared to those of non-lesional skin after 8 weeks. Also, we observed that the improvements in the brightness of melasma lesions and solar lentigo lesions were similar. However, the redness of melasma lesions improved more than that of solar lentigo lesions with statistical significance after 8 weeks. In this study, we have shown that brightness and redness in melasma lesions can be improved by functional cosmetics. Thus, we suggest redness to be an additional suitable parameter for the evaluation of melasma lesions.
Melasma has several well-recognized etiologic factors, but most researches focus on melanogenesis. The purpose of this study is to show improvement of melasma by reducing vascularity distinguished from melanogenesis. We examined 20 Korean women with both melasma and solar lentigo that were visually assessed by a dermatologist. The volunteers applied functional cosmetics for 8 weeks. We analyzed the results obtained using the chromameter, evaluating the skin color of three areas (melasma lesions, solar lentigo lesions, and non-lesional skin) on the face of volunteer. There was a statistically significant improvement in the brightness and redness of melasma lesions compared to those of non-lesional skin after 8 weeks. Also, we observed that the improvements in the brightness of melasma lesions and solar lentigo lesions were similar. However, the redness of melasma lesions improved more than that of solar lentigo lesions with statistical significance after 8 weeks. In this study, we have shown that brightness and redness in melasma lesions can be improved by functional cosmetics. Thus, we suggest redness to be an additional suitable parameter for the evaluation of melasma lesions.
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가설 설정
In this clinical study, we measured that the improvement of brightness and redness by using functional cosmetics in females who have pigmented skin. Brightness in both melasma lesions and solar lentigo lesions was improved compared with non-lesional skin.
A few pathogenesis of melasma such as UV light exposure, hormone change, increased vascularity, defective barrier function, and inflammation have been identified[2,5,14]. In this study, we considered solar lentigo. The pathogenesis of solar lentigo is commonly known to relate to UV light exposure[15,16].
제안 방법
Each volunteer visited our facility, four times during two months (baseline, 2 weeks, 4 weeks, and 8 weeks) for measurement. No use of facial cosmetics was allowed on scheduled evaluation days.
Although most of the clinical studies showed increased melanin in both lesions, alteration of vascularity was referred another pathogenesis in case of melasma. In this study, we compared and analyzed the results obtained by the chromameter in evaluating the skin color of three areas on the face where the females applied cosmetic formulations in order for 8 weeks.
Total color difference (∆E) was calculated from CIE L*a*b* as follows: ∆E = [(∆L*)2 + (∆a*)2 + (∆b*)2]1/2. Total color differences were calculated between solar lentigo lesions and non-lesional skin, melasma lesions and non-lesional skin, melasma lesions and solar lentigo lesions.
대상 데이터
Twenty healthy Korean females (aged 44.45 ± 5.29) who had melasma and solar lentigo simultaneously on the face were enrolled.
데이터처리
All measurements were conducted three times and averages were obtained to evaluate correlations. The relationships between each measured area at baseline were analyzed using repeated measures of ANOVA (p < 0.
Results are given as mean ± S.D. Statistical analysis was performed by repeated measures ANOVA.
Statistical analysis was performed by repeated measures ANOVA.
The relationships between each measured area at baseline were analyzed using repeated measures of ANOVA (p < 0.05).
성능/효과
Therefore, it suggested that higher value of a* in the melasma lesions compared to the non-lesional skin is due to increased vascularity in melasma lesions[5]. After 8 weeks, the redness of melasma lesions, solar lentigo lesions, and non-lesional skin decreased by 8.19%, 2.81%, and 2.96%, respectively (data not shown). We observed that the redness of melasma lesions decreased more than that of solar lentigo lesions and non-lesional skin with statistical significance (p < 0.
The values of L* in melasma lesions and solar lentigo lesional skin improved more than in non-lesional skin with statistical significance at 8 weeks (p < 0.05), and L* and ∆E values between melasma lesions and solar lentigo lesions did not significant differences.
후속연구
This study has limitations such as having no control group and active ingredients are simultaneously present in the formulations. Further study is needed with the control group, and to confirm whether the results come from the synergy of the combination of the materials or from specific individual material.
참고문헌 (20)
A. C. Handel, L. D. Miot, and H. A. Miot, Melasma: a clinical and epidemiological review, An. Bras. Dermatol., 89(5), 771 (2014).
D. L. Bissett, K. Miyamoto, P. Sun, J. Li, and C. A. Berge, Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin, Int. J. Cosmet. Sci., 26(5), 231 (2004).
S. Im, J. Kim, W. Y. On, and W. H. Kang, Increased expression of alpha-melanocyte-stimulating hormone in the lesional skin of melasma, Br. J. Dermatol., 146(1), 165 (2002).
D. J. Lee, J. Lee, J. Ha, K. C. Park, J. P. Ortonne, and H. Y. Kang, Defective barrier function in melasma skin, J. Eur. Acad. Dermatol. Venereol., 26(12), 1533 (2012).
E. H. Kim, Y. C. Kim, E. S. Lee, and H. Y. Kang, The vascular characteristics of melasma, J. Dermatol. Sci., 46(2), 111 (2007).
W. H. Kang, K. H. Yoon, E. S. Lee, J. Kim, K. B. Lee, H. Yim, S. Sohn, and S. Im, Melasma: histopathological characteristics in 56 Korean patients, Br. J. Dermatol., 146(2), 228 (2002).
L. Zaleski, S. Fabi, and M. P. Goldman, Treatment of melasma and the use of intense pulsed light: a review, J. Drugs Dermatol., 11(11), 1316 (2012).
S. Rahrovan, H. Hasanzadeh, S. Khodakarim, and A. Firooz, Biophysical characteristics of melasma skin comparing with the perilesional normal skin and its relation to the melasma subtype, J. Pigment. Disord., 2(11), 222 (2015).
Y. H. Jang, J. H. Sim, H. Y. Kang, Y. C. Kim, and E. S. Lee, The histopathological characteristics of male melasma: comparison with female melasma and lentigo, J. Am. Acad. Dermatol., 66(4), 642 (2012).
J. Navarrete-Solis, J. P. Castanedo-Cazares, B. Torres-Alvarez, C. Oros-Ovalle, C. Fuentes-Ahumada, F. J. Gonzalez, J. D. Martinez-Ramirez, and B. Moncada, A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma, Dermatol. Res. Pract., 2011, 379173 (2011).
T. Hakozaki, L. Minwalla, J. Zhuang, M. Chhoa, A. Matsubara, K. Miyamoto, A. Greatens, G. G. Hillebrand, D. L. Bissett, and R. E. Boissy, The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer, Br. J. Dermatol., 147(1), 20 (2002).
N. Akhtar, M. S. Khan, A. Iqbal, B. A. Khan, and S. Bashir, Glycyrrhiza glabra extract cream: effects on skin pigment melanin, International Conference on Bioscience, Biochemistry and Bioinformatics, 5, 434 (2011).
F. C. Victor, J. Gelber, and B. Rao, Melasma: a review, J. Cutan. Med. Surg., 8(2), 97 (2004).
D. Kovacs, G. Cardinali, N. Aspite, C. Cota, F. Luzi, B. Bellei, S. Briganti, A. Amantea, M. R. Torrisi, and M. Picardo, Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo, Br. J. Dermatol., 163(5), 1020 (2010).
R. G. Langley, E. Burton, N. Walsh, I. Propperova, and S. J. Murray, In vivo confocal scanning laser microscopy of benign lentigines: comparison to conventional histology and in vivo characteristics of lentigo maligna, J. Am. Acad. Dermatol., 55(1), 88 (2006).
Y. Kaymak and M. Onder, An investigation of efficacy of topical niacinamide for the treatment of mild and moderate acne vulgaris, J. Turk. Acad. Dermatol., 2(4), jtad82402a (2008).
J. Wohlrab and D. Kreft, Niacinamide - mechanisms of action and its topical use in dermatology, Skin Pharmacol. Physiol., 27(6), 311 (2014).
Z. D. Draelos, K. Ertel, and C. Berge, Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea, Cutis, 76(2), 135 (2005).
T. Yokota, H. Nishio, Y. Kubota, and M. Mizoguchi, The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation, Pigment. Cell Res., 11(6), 355 (1998).
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