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NTIS 바로가기한국수산과학회지 = Korean journal of fisheries and aquatic sciences, v.50 no.3, 2017년, pp.302 - 310
양혜림 (제주대학교 해양생명과학과) , 권혁재 (제주대학교 해양생명과학과) , 이성도 (제주대학교 해양생명과학과) , (제주대학교 해양생명과학과) , 김명진 (제주대학교 해양생명과학과) , 이제희 (제주대학교 해양생명과학과)
Interferon regulatory factor 8 (IRF8) is essential for the development of B and T cells, as well as for the activity of dendritic cells and macrophages. We performed molecular characterization of IRF8 from rock fish, Sebastes schlegelii (Ss), and investigated the spatial and temporal profile of mRNA...
핵심어 | 질문 | 논문에서 추출한 답변 |
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IRF의 역할은? | Interferon regulatory factor (IRF) family는 바이러스에 대한 방어, 병원체에 대한 초기 면역반응, 세포의 성장과 세포자멸, 림프구의 발달 등 의 역할을 하며(Barnes et al., 2002 ), 현재까지 척추동물에서는 11개의 IRF family가 보고되어 있다(Huang et al. | |
인터페론의 기능은? | IRF에 의해 인터페론(interferon, IFN)과interferon stimulated genes (ISGs)의 전사가 조절된다고 알려져 있으며(Nguyen et al., 1997), 인터페론은 사이토카인 중 하나로 척추동물의 생체 내에서 항 바이러스 반응, 면역조절 기능, 세포의 성장과 분화, 세포자살 등과 같은 중요한 기능을 하고 있다(Pfeffer et al., 1998). | |
인터페론이 바이러스에 대처하는 방법은? | , 1998). 그리고 구조와 기능에 따라 Type I 과 Type II IFN으로 나뉘며(Inkpen et al., 2015), 바이러스에 감염되었을 때 Type I IFNs (IFNα 와 IFNβ)이 생성되어 Type I IFNs이 세포의 특이적 수용체와 결합하여 하위 유전자의 전사를 유도한다(Mamane et al., 1999; Taniguchi et al. |
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Holland JW, Karim A, Wang T, Alnabulsi A, Scott J, Collet B, Mughal MS, Secombes CJ and Bird S. 2010. Molecular cloning and characterization of interferon regulatory factors 4 and 8 (IRF-4 and IRF-8) in rainbow trout, Oncorhynchus mykiss. Fish Shellfish Immunol 29, 157-166. http://dx.doi.org/10.1016/j.fsi.2010.03.001.
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Lehtonen A, Lund R, Lahesmaa R, Julkunen I, Sareneva T and Matikainen S. 2003. $IFN-{\alpha}$ and IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4, and IRF-8 gene expression in human NK and T cells. Cytokine 24, 81-90. http://dx.doi.org/10.1016/j.cyto.2003.07.001.
Lu R. 2008. Interferon regulatory factor 4 and 8 in B-cell development. Trends Immunol 29, 487-492. http://dx.doi.org/10.1016/j.it.2008.07.006.
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Marecki S, Atchison ML and Fenton MJ. 2015. Differential Expression and Distinct Functions of IFN Regulatory Factor 4 and IFN Consensus Sequence Binding Protein in Macrophages. J Immunol 163, 2713-2722.
Nehyba J, Hrdlikova R, Burnside J and Bose HR. 2002. A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein. Mol Cell Biol 22, 3942-3957. http://dx.doi.org/10.1128/MCB.22.11.3942-3957.2002.
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Tailor P, Tamura T, Kong HJ, Kubota T, Kubota M, Borghi P, Gabriele L and Ozato K. 2007. The Feedback Phase of Type I Interferon Induction in Dendritic Cells Requires Interferon Regulatory Factor 8. Immunity 27, 228-239. http://dx.doi.org/10.1016/j.immuni.2007.06.009.
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Zhang J, Li Y and Hu Y. 2015. Molecular characterization and expression analysis of eleven interferon regulatory factors in half-smooth tongue sole, Cynoglossus semilaevis. Fish Shellfish Immunol 44, 272-282. http://dx.doi.org/10.1016/j.fsi.2015.02.033.
Zhao J, Hee JK, Li H, Huang B, Yang M, Zhu C, Bogunovic M, Zheng F, Mayer L, Ozato K, Unkeless J and Xiong H. 2006. IRF-8/interferon (IFN) consensus sequence-binding protein is involved in toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and $IFN-{\gamma}$ signaling pathways. J Biol Chem 281, 10073-10080. http://dx.doi.org/10.1074/jbc.M507788200.
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