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Abstract AI-Helper 아이콘AI-Helper

Purpose: To report our experience of endoscopic botulinum toxin injection in patients who experienced severe delayed gastric emptying after pylorus-preserving gastrectomy (PPG). Materials and Methods: We reviewed the medical records of 6 patients who received the botulinum toxin injection. They pres...

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제안 방법

  • All patients underwent follow-up esophagogastroduodenoscopy at a median of 38 days after botulinum toxin injection (range, 6–148 days).
  • Two patients received additional botulinum toxin injections. One patient underwent one additional procedure due to a recurrence of symptoms, such as nausea and vomiting 5 months after the first botulinum toxin injection. The other patient showed little (grade 1) to no residual remnant food in 6 monthly endoscopic examinations after botulinum toxin injection; however, he strongly desired to receive repeated botulinum toxin injection due to indigestion recurrence at 6 months after each botulinum toxin injection.
  • In the future, a prospective study including a larger number of patients is needed to evaluate the efficacy of botulinum toxin. Second, the effect of botulinum toxin injection on gastric stasis was evaluated semi-quantitatively, based on the improvement of symptoms, diet grade, and endoscopic findings. A gastric emptying study as an objective evaluation method was not conducted.
  • The GOOSS score improved in all patients, and 5 of them were able to consume a soft solid diet within 10 days after the procedure. To our knowledge, this study is the first to report the use of botulinum toxin to alleviate delayed gastric emptying after PPG.
  • The Gastric Outlet Obstruction Scoring System (GOOSS) was used to assess the severity of symptoms before and after botulinum toxin injection as follows: 0) no oral intake; 1) only liquid diet; 2) soft solid diet; and 3) low residue or full diet [10,11]. We checked the GOOSS score of each patient before and 10 days after the procedure and at every outpatient clinic visit. Improvements in delayed gastric emptying were defined as the relief of gastric outlet obstruction symptoms or improvement in the GOOSS score 10 days after the procedure.
  • We retrospectively reviewed the outcome of this procedure using medical records and telephone interviews. The Gastric Outlet Obstruction Scoring System (GOOSS) was used to assess the severity of symptoms before and after botulinum toxin injection as follows: 0) no oral intake; 1) only liquid diet; 2) soft solid diet; and 3) low residue or full diet [10,11].

대상 데이터

  • 9% normal saline solution) was injected into the 4 quadrants of the prepyloric area (within 1 cm of the pyloric channel) after the sclerotherapy needle tip was buried firmly into the gastric wall. These procedures were performed by 3 expert endoscopists (Fig. 1).
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참고문헌 (14)

  1. 1 Bollschweiler E Berlth F Baltin C Mönig S Hölscher AH Treatment of early gastric cancer in the Western World World J Gastroenterol 2014 20 5672 5678 24914327 

  2. 2 Oh SY Lee HJ Yang HK Pylorus-preserving gastrectomy for gastric cancer J Gastric Cancer 2016 16 63 71 27433390 

  3. 3 Jiang X Hiki N Nunobe S Fukunaga T Kumagai K Nohara K Postoperative outcomes and complications after laparoscopy-assisted pylorus-preserving gastrectomy for early gastric cancer Ann Surg 2011 253 928 933 21358534 

  4. 4 Suh YS Han DS Kong SH Kwon S Shin CI Kim WH Laparoscopy-assisted pylorus-preserving gastrectomy is better than laparoscopy-assisted distal gastrectomy for middle-third early gastric cancer Ann Surg 2014 259 485 493 23652333 

  5. 5 Nakabayashi T Mochiki E Garcia M Haga N Suzuki T Asao T Pyloric motility after pylorus-preserving gastrectomy with or without the pyloric branch of the vagus nerve World J Surg 2002 26 577 583 12098048 

  6. 6 Cerfolio RJ Bryant AS Canon CL Dhawan R Eloubeidi MA Is botulinum toxin injection of the pylorus during Ivor Lewis [corrected] esophagogastrectomy the optimal drainage strategy? J Thorac Cardiovasc Surg 2009 137 565 572 19258066 

  7. 7 Bromer MQ Friedenberg F Miller LS Fisher RS Swartz K Parkman HP Endoscopic pyloric injection of botulinum toxin A for the treatment of refractory gastroparesis Gastrointest Endosc 2005 61 833 839 15933684 

  8. 8 Storr M Allescher HD Rösch T Born P Weigert N Classen M Treatment of symptomatic diffuse esophageal spasm by endoscopic injection of botulinum toxin: a prospective study with long term follow-up Gastrointest Endosc 2001 54 18A 11427836 

  9. 9 Kolbasnik J Waterfall WE Fachnie B Chen Y Tougas G Long-term efficacy of botulinum toxin in classical achalasia: a prospective study Am J Gastroenterol 1999 94 3434 3439 10606299 

  10. 10 Adler DG Baron TH Endoscopic palliation of malignant gastric outlet obstruction using self-expanding metal stents: experience in 36 patients Am J Gastroenterol 2002 97 72 78 11808972 

  11. 11 Kim CG Choi IJ Lee JY Cho SJ Park SR Lee JH Covered versus uncovered self-expandable metallic stents for palliation of malignant pyloric obstruction in gastric cancer patients: a randomized, prospective study Gastrointest Endosc 2010 72 25 32 20381802 

  12. 12 Kubo M Sasako M Gotoda T Ono H Fujishiro M Saito D Endoscopic evaluation of the remnant stomach after gastrectomy: proposal for a new classification Gastric Cancer 2002 5 83 89 12111583 

  13. 13 Jung HJ Lee JH Ryu KW Lee JY Kim CG Choi IJ The influence of reconstruction methods on food retention phenomenon in the remnant stomach after a subtotal gastrectomy J Surg Oncol 2008 98 11 14 18461561 

  14. 14 Bae JS Kim SH Shin CI Joo I Yoon JH Lee HJ Efficacy of gastric balloon dilatation and/or retrievable stent insertion for pyloric spasms after pylorus-preserving gastrectomy: retrospective analysis PLoS One 2015 10 e0144470 26657405 

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