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NTIS 바로가기동의신경정신과학회지 = Journal of oriental neuropsychiatry, v.28 no.3, 2017년, pp.145 - 156
주환수 (자생한방병원 한방신경정신과) , 유옥철 (자생한방병원 한방신경정신과) , 한창 (자생한방병원 한방신경정신과) , 양규진 (자생한방병원 침구과) , 이성엽 (자생한방병원 한방부인과) , 문혜연 (자생한방병원 한방부인과)
Objectives: The purpose of this study is to review experimental studies of Parkinson's Disease in Korean medical journals, which have been published since 1990. Methods: Experimental studies related to Parkinson's disease published in Korean medical journals, registered with Korea research foundatio...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
파킨슨병이란? | 파킨슨병은 뇌흑질(substantia nigra) 부위의 도파민 신경이 사멸하여 선조체(striatum)로 연결되는 흑질-선조체 도파민성 신경계(nigrostriatal dopaminergic system)의 신경 전달에 장애가 나타나 그 기능이 소실되어 나타나는 질병으로 알츠하이머 병 다음으로 높은 유병율을 보이는 퇴행성 뇌질환으로 일반적인 증상으로는 서동(bradykinesia), 근경직의 증가(rigidity), 안정 떨림(rest tremor), 행동의 동결(freezing), 자세의 변화(postural change), 비정상적인 자세 반사(abnormal postural reflex) 등이 나타난다1). | |
파킨슨병의 증상은? | 파킨슨병은 뇌흑질(substantia nigra) 부위의 도파민 신경이 사멸하여 선조체(striatum)로 연결되는 흑질-선조체 도파민성 신경계(nigrostriatal dopaminergic system)의 신경 전달에 장애가 나타나 그 기능이 소실되어 나타나는 질병으로 알츠하이머 병 다음으로 높은 유병율을 보이는 퇴행성 뇌질환으로 일반적인 증상으로는 서동(bradykinesia), 근경직의 증가(rigidity), 안정 떨림(rest tremor), 행동의 동결(freezing), 자세의 변화(postural change), 비정상적인 자세 반사(abnormal postural reflex) 등이 나타난다1). | |
파킨슨병에 대한 실험적 연구를 검토하여 어떠한 결론을 얻었는가? | 1. 현재까지 한의학회에서 연구 조사된 파킨슨병 관련 실험 논문은 총 22편이었으며, 대한한의학회지와 대한침구의학회지에서 각 4편씩 가장 많은 수의 연구가 이루어지고 있었고, 총 8개의 다른 한의학회지에서 파킨슨병 연구를 하였다. 2. 파킨슨병의 한의학적 접근에 관한 22편의 실험적 연구 중 단미제 관련 연구가 7편, 복합 처방 관련 연구가 6편으로 한약제에 관한 연구 논문이 59%의 비중을 차지했으며, 그 외에도 봉독약침, 약침, 침자극 등을 이용하여 세포 손상 및 사멸, 염증 억제, 항산화 등 다방면의 연구가 이루어졌다. 3. 22편의 실험 논문 대부분 MPTP, MPP+, 독성 물질로 유도된 파킨슨병 병태 모델 연구 형태를 취하고 있으며, 많은 연구에서 세포 독성과 생존율을 알아보기 위해 MTT assay 실험이 진행되었다. 4. 파킨슨병 모델 실험용 동물의 행동실험은 pole test, rotarod test, morris water maze test, forced swimming test가 주로 시행되었다. 5. 파킨슨병에 관한 실험 연구 목적은 크게 도파민 신경세포 보호효과에 관한 연구, 세포 사멸에 대한 신경세포 보호 효과에 관한 연구, 세포에 대한 항염증 효과에 관한 연구, 산화적 손상에 대한 항산화 효과에 관한 연구로 나눌 수 있다 |
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