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NTIS 바로가기생명과학회지 = Journal of life science, v.28 no.11 = no.223, 2018년, pp.1301 - 1315
이민정 (국립수산과학원 생명공학과) , 오륜경 (국립수산과학원 생명공학과) , 김영옥 (국립수산과학원 생명공학과) , 남보혜 (국립수산과학원 생명공학과) , 공희정 (국립수산과학원 생명공학과) , 김주원 (국립수산과학원 생명공학과) , 박중연 (국립수산과학원 생명공학과) , 서정길 (군산대학교 식품생명과학부) , 김동균 (국립수산과학원 생명공학과)
We purified an antimicrobial peptide from the acidified hemocyte extract of Mytilus coruscus by
핵심어 | 질문 | 논문에서 추출한 답변 |
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항균 펩타이드란 무엇인가? | 항균 펩타이드는 약 12~100개의 아미노산으로 구성된 분자량이 10 kDa 이하의 단백질성 물질로 침입 미생물에 대해 즉각적으로 대응 반응을 보이는 항미생물 물질이다[2, 4]. 이들의 구조는 α-helix나 β-sheet 또는 random coil 형태를 띄며 cysteine을 다량 포함하는 defensin과 같이 하나 이상의 특정 아미노산을 반복 또는 다량으로 가지는 경우도 있다[6, 8]. | |
척추동물 이상 동물류의 면역 체계 구성은 어떻게 되는가? | 다양한 생물 중 척추동물 이상 동물류는 선천적 면역 체계(innate immune system)와 후천적 면역 체계(acquired immune system)를 가지고 있으며, 두 가지 면역 체계를 이용하여 비자기 외부물질을 인식, 선별한 뒤 다양한 반응을 통하여 제거 또는 불활 시킴으로써 자신의 몸을 보호한다[3]. 그러나 무척추 동물들은 후천적 면역 체계가 덜 발달되었기 때문에 체액성 면역(humoral immunity)과 세포성 면역(cellular immunity)을 포함하는 선천적 면역 체계에 의존하여 외부환경이나 외부물질로부터 체내의 항상성을 유지하며 살아간다 [40]. | |
해양 무척추 동물의 선천적 면역 체계의 2가지 종류와 그와 관련된 반응은 무엇인가? | 해양 무척추 동물의 경우 체액성 면역은 주로 혈액 세포나 혈장에 존재하는 항균 물질에 의해 일어나며 혈액림프 응고(hemolymph coagulation)나 멜라닌화(melanization) 등과 같 은 반응과 함께 일어난다[36, 38]. 그리고 세포성 면역은 캡슐화(encapsulation), 결절형성(nodule formation), 식세포 작용(phagocytosis) 등을 포함하는 세포 방어 반응을 근거로 한다[40]. 특히, 해양 무척추 동물의 세포성 면역은 혈구에 의해 조절되는데 이는 식세포 작용이 일어난 물질, 항균활성 물질, 세포독성 물질 등 운동성을 가진 세포를 혈액림프로 분비한 [29]. |
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