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NTIS 바로가기한국식품과학회지 = Korean journal of food science and technology, v.50 no.6, 2018년, pp.653 - 659
최은영 (대구한의대학교 화장품약리학과) , 이진태 (대구한의대학교 화장품약리학과)
In this study, we investigated the antioxidant activities and anti-aging efficacy in terms of suppression of matrix metalloproteinases (MMPs) in UVB-irradiated HaCaT cells by adding the ethanol extracts of Josaengheogchal (JE) and Shintoheug rice (SRE). In the electron-donating ability and ABTS radi...
핵심어 | 질문 | 논문에서 추출한 답변 |
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MMPs group 중 collagenase group에서 분해하는 콜라겐은? | MMPs group은 collagenase, gelatinase, stromelysin, membranetype MMP로 나눌 수 있으며, 약 20여 종류가 알려져 있다(Brinckerhoff 등, 2000). 이 중 collagenase group에는 MMP-1, -8,-13이 포함되며 주로 제 I형, II형, III형 콜라겐을 분해한다. Gelatinase group에는 MMP-2, -9가 포함되며 MMP-1에 의해 분해된 콜라겐 조각들을 더 잘게 분해해 피부 노화에 주요한 역할을 한다. | |
외인성 노화(extrinsic aging)의 특징? | 피부 노화요인 가운데 외인성 노화(extrinsic aging)는 태양광선 등의 누적된 외부 스트레스에 의해 피부가 얇아지거나 주름이 증가되고 탄력이 감소되고 기미, 주근깨 및 검버섯 등이 증가하게 된다. 특히 UVB는 피부 섬유아세포와 표피상피세포의 DNA에 직접적인 손상을 주어 화상, 광노화, 피부암 등을 촉발하는 경로와 간접적으로는 활성산소종(reactive oxygen species, ROS) 생성으로 인한 세포의 지방질막 손상과 세포 염증반응, 피부 구성단백질의 손상 등에 의한 광노화(photoaging)를 유발시킨다(Sun 등,2015). | |
UVB가 유발시키는 현상? | 피부 노화요인 가운데 외인성 노화(extrinsic aging)는 태양광선 등의 누적된 외부 스트레스에 의해 피부가 얇아지거나 주름이 증가되고 탄력이 감소되고 기미, 주근깨 및 검버섯 등이 증가하게 된다. 특히 UVB는 피부 섬유아세포와 표피상피세포의 DNA에 직접적인 손상을 주어 화상, 광노화, 피부암 등을 촉발하는 경로와 간접적으로는 활성산소종(reactive oxygen species, ROS) 생성으로 인한 세포의 지방질막 손상과 세포 염증반응, 피부 구성단백질의 손상 등에 의한 광노화(photoaging)를 유발시킨다(Sun 등,2015). 매우 낮은 강도의 UVB에 의한 피부세포의 산화 스트레스의 증가는 matrix metalloproteinase (MMP)의 발현을 가속화시켜 피부 콜라겐이 감소하게 된다(Jenkins, 2002; Oh 등, 2015). |
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