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NTIS 바로가기Journal of the Korean Society of Integrative Medicine = 대한통합의학회지, v.6 no.4, 2018년, pp.183 - 189
문현주 (미주신경연구센터) , 구봉오 (부산가톨릭대학교 물리치료학과)
Purpose : As age increases, a low-level systemic inflammatory state develops and the levels of anti-aging hormones decrease. The vagus nerve activates parasympathetic nerves and promotes sulfation and secretion of neurotransmitter in the brain. Therefore, the purpose of this study was to investigate...
핵심어 | 질문 | 논문에서 추출한 답변 |
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전신적 염증수준이 노화의 지표로 사용될 수 있는 이유는 무엇인가? | 노화와 관련된 또 다른 지표로서 전신적 염증수준을 들 수 있다. 노인들은 염증전구물질 생성을 억제하는 능력이 떨어지는데(Xia 등, 2017), 건강한 노인에게서 조차도 젊은 성인에 비해 혈중 염증 전구물질의 분비량이 2배에서 4배 이상 많은 것을 볼 때 노화와 염증간의 비례적 상관성이 있음을 알 수 있다(Bruunsgaad & Pedersen, 2003). 노인들의 전신쇠약과 염증수준을 비교한 연구에서 염증수준이 높은 노인일수록 전신적 쇠약감을 많이 느꼈으며(Hubbard 등, 2009; Cesari 등, 2004), 또한 전신적 염증수준이 높은 노인일수록 여러 신체 기관 및 근육들의 약증이 많이 나타났다. | |
염증반응단백은 무엇인가? | 노인들의 전신쇠약과 염증수준을 비교한 연구에서 염증수준이 높은 노인일수록 전신적 쇠약감을 많이 느꼈으며(Hubbard 등, 2009; Cesari 등, 2004), 또한 전신적 염증수준이 높은 노인일수록 여러 신체 기관 및 근육들의 약증이 많이 나타났다. 특히 염증반응단백(C-reactive protein: CRP)은 전신적인 염증수준을 대표하는 급성기 염증반응단백인자로서, 노인에게서 CRP가 증가될수록 만성질환의 이환률과 사망률이 증가함을 여러 연구를 통해 확인하였다(Beleigoli 등, 2013; Puzianowska- Kuznicka 등, 2016). | |
DHEA-S가 신체에 미치는 영향은 무엇인가? | 이러한 DHEA-S는 신체 전반에 걸쳐 여러 생리적작용에 영향을 미치는데, 특히 뇌에서는 항산화와 항염증 작용을 통해 신경세포의 보호 역할을 하는 것으로 알려져 있다. 또한 DHEA-S가 면역반응에도 관여함으로써 DHEA-S가 여러 호르몬과 함께 염증 조절에 영향을 미친다고 하였는데(Prall과 Muehlenbein, 2018), 염증성 질환자는 DHEA-S의 전신적 수준이 낮음을 관찰함으로써 전신적 염증수치와 DHEA-S 수준 간에 역상관성이 있음을 확인하였다(Liou 등, 2018). |
Baulieu EE(2002). Androgens and aging men. Mol Cell Endocrinol, 198(1-2), 41-49.
Bruunsgaard H, Pederson BK(2003). Age-related inflammatory cytokines and disease. Immunnol Allergy Clin North Am, 23(1), 15-39.
Beleigoli AM, Boersma E, Diniz Mde F, et al(2013). C-reactive protein and B type natriuretic peptide yield either a non-significant or a modest incremental value to traditional risk factors in predicting long-term overall mortality in older adults. PLoS One, 8(9), e75809.
Cesari M, Penninx BW, Pahor M, et al(2004). Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci, 59(3), 242-248.
Clancy JA, Mary DA, Witte KK, et al(2014). Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity. Brain Stimul, 7(6), 871-877.
Carreno FR, Frazer A(2017). Vagal nerve stimulation for treatment-resistant depression. Neurotherapeutics, 14(3), 716-727.
Diamanti-Kandarakis E, Dattilo M, Macut D, et al(2016). Biology of healthy aging and longevity. Rev Invest Clin, 68(1), 7-16.
Ekici F, Karson A, Dillioglugil MO, et al(2013). The effects of vagal nerve stimulation in focal cerebral ischemia and reperfusion model. Turk Neurosurg, 23(4), 451-457.
Eisenhofer G, Peitzsch M, Kaden D, et al(2017). Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS/MS: Impact of gender, age, oral contraceptives, body mass index and blood pressure status. Clin Chim Acta, 470, 115-124.
Fang J, Egorova N, Rong P, et al(2016). Early cortical biomarkers of longitudinal transcutaneous vagus nerve stimulation treatment success in depression. Neuroimage Clin, 14, 105-111.
Hubbard RE, O'Mahony MS, Savva GM, et al(2009). Inflammation and frailty measures in older people. J Cell Mol Med, 13(9B), 3103-3109.
Hashimoto T, Ichiki T, Watanabe A, et al(2014). Stimulation of $\alpha$ 7 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice. Vascul Pharmacol, 61(2-3), 49-55.
Jeremias IC, Victorino VJ, Barbeiro HV, et al(2016). The role of acetylcholine in the inflammatory response in animals surviving sepsis induced by cecal ligation and puncture. Mol Neurobiol, 53(10), 6635-6643.
Jiang Y, Li L, Tan X, et al(2015). miR-210 mediates vagus nerve stimulation-induced antioxidant stress and anti-apoptosis reactions following cerebral ischemia/ reperfusion injury in rats. J Neurochem, 134(1), 173-181.
Komegae EN, Farmer DGS, Brooks VL, et al(2018). Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway. Brain Behav Immun, 73, 441-449.
Kwon HY, Moon HJ(2016). New methods of vagus nerve stimulation: therapeutic effects of non-invasive vagus nerve stimulation by TENS application. J Korean Soc Integrative Med, 4(4), 77-82.
Liou CJ, Yang CM, Lee TH, et al(2018). Neuroprotective effects of dehydroepiandrosterone sulfate through inhibiting expression of matrix metalloproteinase-9 from bradykinin-challenged astroglia. Mol Neurobiol, doi: 10.1007/s12035-018-1125-6.
Miranda RA, Torrezan R, de Oliveira JC, et al(2016). HPA axis and vagus nervous function are involved in impaired insulin secretion of MSG-obese rats. J Endocrinol, 230(1), 27-38.
Meyers EE, Kronemberger A, Lira V, et al(2016). Contrasting effects of afferent and efferent vagal nerve stimulation on insulin secretion and blood glucose regulation. Physiol Rep, 4(4), e12718.
Okada T, Waise TMZ, Toshinai K, et al(2018). Analysis of peripheral ghrelin signaling via the vagus nerve in ghrelin receptor-restored GHSR-null mice. Neurosci Lett, 681, 50-55.
Payne AH, Hales DB(2004). Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocrine Reviews, 25(6), 947-970.
Pellissier S, Dantzer C, Mondillon L, et al(2014). Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome. PLoS One, 9(9), e105328.
Puzianowska-Kuznicka M, Owczarz M, WieczorowskaTobis K, et al(2016). Interleukin-6 and C-reactive protein, successful aging, and mortality: the Pol Senior study. Immun Ageing, 13, 21.
Prall SP, Muehlenbein MP(2018). DHEA modulates immune function: A review of evidence. Vitam Horm, 108, 125-144.
Rong PJ, Fang JL, Wang LP, et al(2012). Transcutaneous vagus nerve stimulation for the treatment of depression: a study protocol for a double blinded randomized clinical trial. BMC Complement Altern Med, 12, 255.
Schweighofer H, Rummel C, Roth J, et al(2016). Modulatory effects of vagal stimulation on neurophysiological parameters and the cellular immune response in the rat brain during systemic inflammation. Intensive Care Med Exp, 4(1), 19.
Straube A, Ellrich J, Eren O, et al(2015). Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial. J Headache Pain, 16, 543.
Tracey KJ(2009). Reflex control of immunity. Nat Rev Immunol, 9(6), 418-428.
Xia JY, Sun K, Hepler C, et al(2017). Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice. Diabetologia, 61(4), 932-941.
Xiang YX, Wang WX, Xue Z, et al(2015). Electrical stimulation of the vagus nerve protects against cerebral ischemic injury through an anti-infammatory mechanism. Neural Regen Res, 10(4), 576-582.
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