최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기한방비만학회지 = Journal of Korean Medicine for Obesity Research, v.18 no.2, 2018년, pp.74 - 82
Objectives: The objective of this study is to investigate the effects of Silbi-um (SBU) extract on the alcoholic fatty liver induced by EtOH administration for 8 weeks. Methods: Male Sprague Dawley rats were used. All animals were randomly divided into 3 groups; Normal, EtOH and EtOH+SBU. The rats o...
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
지방간(fatty liver)이란 무엇인가? | 지방간(fatty liver)이란 여러 원인에 의해 간 조직에 지질이 축적되어 지방방울(lipid droplet)을 함유한 간세포가 5% 이상을 넘게 되어 결국 간기능을 저하시키게 되는 질환을 말한다1). 지방간은 비만, 당뇨, 알코올 섭취 및 이상지질혈증(dyslipidemia) 등에 의해 발생할 수 있다2). | |
간에서의 지방산의 증가 및 중성지방 합성이 증가하게 되면 이후 어떠한 문제를 유발할 수 있나? | 특히 알코올을 다량으로 장기간 섭취하게 되면 대사기능의 장애가 나타나고, 이에 따라 간에서의 지방산의 증가 및 중성지방 합성이 증가하게 되어 알코올성 지방간(alcoholic fatty liver)이 발생하게 된다3). 이러한 간에서의 지질 축적은 알코올성 간질환의 중요한 특징으로 질병의 초기 단계임을 나타내는데, 이후 간의 염증, 섬유화, 간경화증 및 간세포의 악성종양 등을 유발할 수 있다4). 알코올에 의해 간손상의 가장 잘 알려진 기전은 free radical 형성에 따른 염증반응과 산화적 손상(oxidative stress)의 유발이다. | |
지방간은 무엇에 의해 발생할 수 있나? | 지방간(fatty liver)이란 여러 원인에 의해 간 조직에 지질이 축적되어 지방방울(lipid droplet)을 함유한 간세포가 5% 이상을 넘게 되어 결국 간기능을 저하시키게 되는 질환을 말한다1). 지방간은 비만, 당뇨, 알코올 섭취 및 이상지질혈증(dyslipidemia) 등에 의해 발생할 수 있다2). 특히 알코올을 다량으로 장기간 섭취하게 되면 대사기능의 장애가 나타나고, 이에 따라 간에서의 지방산의 증가 및 중성지방 합성이 증가하게 되어 알코올성 지방간(alcoholic fatty liver)이 발생하게 된다3). |
Okumura, Toshikatsu. Role of lipid droplet proteins in liver steatosis. Journal of physiology and biochemistry, vol.67, no.4, 629-636.
Carr, R.M., Ahima, R.S.. Pathophysiology of lipid droplet proteins in liver diseases. Experimental cell research, vol.340, no.2, 187-192.
Liu, Jinyao. Ethanol and liver: Recent insights into the mechanisms of ethanol-induced fatty liver. World journal of gastroenterology : WJG, vol.20, no.40, 14672-.
Dongiovanni, Paola. Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors. World journal of gastroenterology : WJG, vol.20, no.36, 12945-.
Ceni, Elisabetta, Mello, Tommaso, Galli, Andrea. Pathogenesis of alcoholic liver disease: Role of oxidative metabolism. World journal of gastroenterology : WJG, vol.20, no.47, 17756-17772.
Chen, Y.L., Peng, H.C., Hsieh, Y.C., Yang, S.C.. Epidermal growth factor improved alcohol-induced inflammation in rats. Alcohol, vol.48, no.7, 701-706.
Suk, Ki Tae. Alcoholic liver disease: Treatment. World journal of gastroenterology : WJG, vol.20, no.36, 12934-.
Lin, H. Z., Yang, S. Q., Zeldin, G., Diehl, A. M.. Chronic Ethanol Consumption Induces the Production of Tumor Necrosis Factor-alpha and Related Cytokines in Liver and Adipose Tissue. Alcoholism: clinical and experimental research, vol.22, no.5, 231s-237s.
Ji, Cheng, Deng, Qinggao, Kaplowitz, Neil. Role of TNF-α in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology : official journal of the American Association for the Study of Liver Diseases, vol.40, no.2, 442-451.
Gong YX. Wan Bing Hui Chun. Taipei: Greater China Book Company; 1983 p. 174.
Wang YY, and Li YX. Clinical experience of Shi pi yin. Chinese Journal of Information on Traditional Chinese Medicine 2011;18:83-4.
Jeon GT, Keum DH, and Lee MJ. The effects of Silbi-um (Shipi-yin) on obesity and antioxidant activities in Zucker rat. J Korean Med Rehabil 2003;13:69-85.
Lim HW, Kang SB, and Kim MR. Effects of Silbieum and Lieum Jeon on rats with acute renal failure induced by gentamicin sulfate. The Journal of East-West Medicines 1993;18:5-20.
Kim JJ, Seo BI, Choi HS, Kim SM, Woo CH, and Koo JS et al. Preventive effects of Daekumeumja on fatty degeneration of liver and immunosuppression induced by alcohol. J Korean Med 2010;16:167-79.
Ma, Zhenhua, Zhang, Yangmin, Li, Qingchun, Xu, Meng, Bai, Jigang, Wu, Shengli. Resveratrol improves alcoholic fatty liver disease by downregulating HIF-1α expression and mitochondrial ROS production. PloS one, vol.12, no.8, e0183426-.
Altavilla, Domenica, Marini, Herbert, Seminara, Paolo, Squadrito, Giovanni, Minutoli, Letteria, Passaniti, Maria, Bitto, Alessandra, Calapai, Gioacchino, Calò, Margherita, Caputi, Achille P., Squadrito, Francesco. Protective Effects of Antioxidant Raxofelast in Alcohol-Induced Liver Disease in Mice. Pharmacology, vol.74, no.1, 6-14.
Augustyniak, Agnieszka, Waszkiewicz, Ewa, Skrzydlewska, Elżbieta. Preventive action of green tea from changes in the liver antioxidant abilities of different aged rats intoxicated with ethanol. Nutrition, vol.21, no.9, 925-932.
Zhou, Jianyu, Zhang, Jianjun, Wang, Chun, Qu, Shengsheng, Zhu, Yingli, Yang, Zhihui, Wang, Linyuan. Açaí ( Euterpe oleracea Mart.) attenuates alcohol-induced liver injury in rats by alleviating oxidative stress and inflammatory response. Experimental and therapeutic medicine, vol.15, no.1, 166-172.
Tayie, F.A., Beck, G.L.. Alcoholic beverage consumption contributes to caloric and moisture intakes and body weight status. Nutrition, vol.32, no.7, 799-805.
Tang, Liying, Yang, Fengli, Fang, Zhirui, Hu, Chengmu. Resveratrol Ameliorates Alcoholic Fatty Liver by Inducing Autophagy. The American journal of Chinese medicine, vol.44, no.6, 1207-1220.
Tan, Peizhu, Liang, Huan, Nie, Junhui, Diao, Yan, He, Qi, Hou, Baoyu, Zhao, Tingting, Huang, Hui, Li, Yanze, Gao, Xu, Zhou, Lingyun, Liu, Ying. Establishment of an alcoholic fatty liver disease model in mice. The American journal of drug and alcohol abuse, vol.43, no.1, 61-68.
Bi, Lijuan, Jiang, Zhian, Zhou, Junying. The Role of Lipin-1 in the Pathogenesis of Alcoholic Fatty Liver. Alcohol and alcoholism : international journal of the Medical Council on Alcoholism, vol.50, no.2, 146-151.
Singh, Sukhpreet, Osna, Natalia A, Kharbanda, Kusum K. Treatment options for alcoholic and non-alcoholic fatty liver disease: A review. World journal of gastroenterology : WJG, vol.23, no.36, 6549-6570.
Gluchowski, Nina L., Becuwe, Michel, Walther, Tobias C., Farese Jr, Robert V.. Lipid droplets and liver disease: from basic biology to clinical implications. Nature reviews. Gastroenterology & hepatology, vol.14, no.6, 343-355.
Ikura Y, and Caldwell SH. Lipid droplet-associated proteins in alcoholic liver disease: a potential linkage with hepatocellular damage. Int J Clin Exp Pathol 2015;8:8699-708.
Purohit, Vishnudutt, Gao, Bin, Song, Byoung‐Joon. Molecular Mechanisms of Alcoholic Fatty Liver. Alcoholism: clinical and experimental research, vol.33, no.2, 191-205.
Eguchi, A., Wree, A., Feldstein, A.E.. Biomarkers of liver cell death. Journal of hepatology : the journal of the European Association for the Study of the Liver, vol.60, no.5, 1063-1074.
Donohue, Terrence M. Alcohol-induced steatosis in liver cells.. World journal of gastroenterology : WJG, vol.13, no.37, 4974-4978.
Lieber, Charles S.. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol, vol.34, no.1, 9-19.
Yang, Wenjuan, Huang, Luming, Gao, Jinhang, Wen, Shilei, Tai, Yang, Chen, Meng, Huang, Zhiyin, Liu, Rui, Tang, Chengwei, Li, Jing. Betaine attenuates chronic alcohol-induced fatty liver by broadly regulating hepatic lipid metabolism. Molecular medicine reports, vol.16, no.4, 5225-5234.
Hsieh, You‐Liang, Yeh, Yen‐Hung, Lee, Ya‐Ting, Huang, Chih‐Yang. Protective effects of Cholestin on ethanol induced oxidative stress in rats. Journal of the science of food and agriculture, vol.95, no.4, 799-808.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.