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Effects of small tidal volume and positive end-expiratory pressure on oxygenation in pressure-controlled ventilation-volume guaranteed mode during one-lung ventilation 원문보기

Yeungnam University Journal of Medicine = 영남의대학술지, v.35 no.2, 2018년, pp.165 - 170  

Byun, Sung Hye (Department of Anesthesiology and Pain Medicine, Catholic University of Daegu School of Medicine) ,  Lee, So Young (Department of Anesthesiology and Pain Medicine, Catholic University of Daegu School of Medicine) ,  Jung, Jin Yong (Department of Anesthesiology and Pain Medicine, Catholic University of Daegu School of Medicine)

Abstract AI-Helper 아이콘AI-Helper

Background: The purpose of this study was to investigate whether tidal volume (TV) of 8 mL/kg without positive end-expiratory pressure (PEEP) and TV of 6 mL/kg with or without PEEP in pressure-controlled ventilation-volume guaranteed (PCV-VG) mode can maintain arterial oxygenation and decrease inspi...

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제안 방법

  • The location of the DLT was examined again with FOB after the patient was placed in lateral decubitus position. All patients underwent surgery using the same anesthetic equipment (Avance, GE Healthcare, Wauwatosa, WI, USA), using PCV-VG as ventilation mode. After induction, tidal volumes were 8-10 mL/kg during two-lung ventilation.
  • 2 mg before entering the operating room as premedication. In the operating room, the electrocardiogram, pulse oximeter, non-invasive blood pressure, and bispectral index were monitored. Anesthesia was induced with 4 μg/mL of propofol and 4 ng/mL of remifentanil, using target controlled infusion (TCI).
  • Ventilation was subsequently changed to TV 6 mL/kg with PEEP (5 cmH2O; group TV6+PEEP) or without (group TV6), in random sequence. Peak airway pressure (Ppeak), mean airway pressure (Pmean), exhaled tidal volume (TVE), peripheral oxygen saturation (SpO2), end-tidal CO2 (ETCO2), and ABGA were measured and examined just before OLV and 30 min after each mode of OLV was applied. Ventilation was changed once more to add or eliminate PEEP (5 cmH2O), while maintaining TV 6 mL/kg.
  • The primary goal of this study was to investigate whether a decrease in tidal volume of 6 mL/kg with or without 5 cmH2O PEEP would be enough to prevent lung barotrauma by reducing inspiratory airway pressure, while maintaining appropriate oxygenation during OLV using PCV-VG, which has the merits of PCV and the tidal volume-designating characteristic of VCV.
  • Respiratory rates during anesthesia were set equally for all patients at 12 times per min. When SpO2 levels were below 90%, or when arterial partial pressure of oxygen (PaO2) was below 80 mmHg in ABGA, subjects were discontinued from this study and hypoxia was corrected by tidal volume elevation, relocation of DLT, or two-lung ventilation, if needed.

대상 데이터

  • 05 statistical significance, using the average and standard deviation of established values [5,9], according to all three ventilation methods. Assuming a 10% drop-out rate, 27 subjects were included in the study. Each mode of ventilation was statistically assessed using SPSS for Windows, version 17.
  • Of the 27 patients, three dropped out and the study was conducted statistically on the remaining 24 subjects. In these three patients, arterial oxygen partial pressure after 30 min of respiration with tidal volume of 6 mL/kg on ABGA was 60.
  • The study proceeded with approval from the institutional review board of our hospital. The study enrolled 27 subjects who were classified as American Society of Anesthesiologists physical status 1 or 2 and scheduled for pulmonary surgery under OLV (Table 1). All subjects provided written informed consent before surgery.
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참고문헌 (14)

  1. Yun du G, Han JI, Kim DY, Kim JH, Kim YJ, Chung RK. Is small tidal volume with low positive end expiratory pressure during one-lung ventilation an effective ventilation method for endoscopic thoracic surgery? Korean J Anesthesiol 2014;67:329-33. 

  2. Kim H. Protective strategies for one-lung ventilation. Korean J Anesthesiol 2014;67:233-4. 

  3. Jung JD, Kim SH, Yu BS, Kim HJ. Effects of a preemptive alveolar recruitment strategy on arterial oxygenation during one-lung ventilation with different tidal volumes in patients with normal pulmonary function test. Korean J Anesthesiol 2014;67:96-102. 

  4. Lee W, Lee JY, Choi DN, Shin CM, Cho K, Kim MH, et al. Airway dimensions and margin of safety with the left-sided double-lumen tube in patients of a short stature. Anesth Pain Med 2015;10:110-7. 

  5. Tugrul M, Camci E, Karadeniz H, Senturk M, Pembeci K, Akpir K. Comparison of volume controlled with pressure controlled ventilation during one-lung anaesthesia. Br J Anaesth 1997;79:306-10. 

  6. Unzueta MC, Casas JI, Moral MV. Pressure-controlled versus volume-controlled ventilation during one-lung ventilation for thoracic surgery. Anesth Analg 2007;104:1029-33. 

  7. Boules NS, Ghobrial HZ. Efficiency of the newly introduced ventilatory mode "pressure controlled ventilation-volume guaranteed" in thoracic surgery with one lung ventilation. Egypt J Anaesth 2011;27:113-9. 

  8. Pu J, Liu Z, Yang L, Wang Y, Jiang J. Applications of pressure control ventilation volume guaranteed during one-lung ventilation in thoracic surgery. Int J Clin Exp Med 2014;7:1094-8. 

  9. Vegh T, Juhasz M, Szatmari S, Enyedi A, Sessler DI, Szegedi LL, et al. Effects of different tidal volumes for one-lung ventilation on oxygenation with open chest condition and surgical manipulation: a randomised cross-over trial. Minerva Anestesiol 2013;79:24-32. 

  10. Keszler M. Volume-targeted ventilation. Early Hum Dev 2006;82:811-8. 

  11. Song SY, Jung JY, Cho MS, Kim JH, Ryu TH, Kim BI. Volume-controlled versus pressure-controlled ventilation-volume guaranteed mode during one-lung ventilation. Korean J Anesthesiol 2014;67:258-63. 

  12. Gal TJ. Con: low tidal volumes are indicated during one-lung ventilation. Anesth Analg 2006;103:271-3. 

  13. Fernandez-Perez ER, Sprung J, Afessa B, Warner DO, Vachon CM, Schroeder DR, et al. Intraoperative ventilator settings and acute lung injury after elective surgery: a nested case control study. Thorax 2009;64:121-7. 

  14. Kim SH, Jung KT, An TH. Effects of tidal volume and PEEP on arterial blood gases and pulmonary mechanics during onelung ventilation. J Anesth 2012;26:568-73. 

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