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Inhibition of Adenovirus 36 Replication and Lipid Accumulation by Distylium racemosum 원문보기

한국유화학회지 = Journal of oil & applied science, v.35 no.2, 2018년, pp.492 - 501  

Kim, Hye-Ran (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ,  Park, Gyu-Nam (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ,  Jung, Bo-Kyoung (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ,  Yoon, Weon-Jong (Jeju Biodiversity Research Institute) ,  Chang, Kyung-Soo (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)

Abstract ▼ AI-Helper 아이콘AI-Helper

Obesity is a worldwide disease and one of the major risk factors. Virus among many factors can lead to obesity. Adenovirus 36 (Ad-36) is the adipogenic virus linked with human obesity. Nevertheless, there is no drug to treat both Ad-36 infection and obesity associated with virus. For the precedent s...

주제어

#Distylium racemosum   #Adenovirus 36   #Anti-lipid   #Anti-cholesterol   #Anti-obesity  

AI 본문요약
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제안 방법

  • Quercetin was used as positive control. The extracts were tested by anti-cholesterol screening test.
  • The primers were designed following as: GAPDH forward - GCT AGG ACT GGA TAA GCA GGG, GAPDH reverse - GAT GGG CTT CCC GTT GAT GA, PPARγ forward-GTG AGA CCA ACA GCC TGA CG, PPARγ reverse - ACA GAC TCG GCA CTC AAT GG, aP2 forward - GAA ATC ACC GCA GAC GAC AG, aP2 reverse - AAC TCT TGT GGA AGT CAC GCC.
  • This study investigated and compared anti-cholesterol effects of extracts from D. racemosum, Q. salicina and R. indica. Quercetin was used as single component and positive control.
  • To examine whether the expression of adipogenic transcription factors is inhibited by the extracts from D. racemosum, Q salicina, R. indica and quercetin, 3T3-L1 preadipocytes were treated with various concentration of the extracts and incubated for 7 days. The expression of PPARγ gene was inhibited from 10 μg/mL quercetin and 50 μg/mL D.

대상 데이터

  • Three natural extracts among them were selected as cholesterol inhibitors. The extracts are extracted from the leaves of Distylium racemosum (D. racemosum), Quercus salicina (Q. salicina) and Raphiolepis indica (R. indica) which are ones of oriental medical plants grown wildly in Jeju. D.
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