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NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.33 no.5, 2018년, pp.53 - 66
심우형 (대구한의대학교 한의과대학 본초학교실) , 서부일 (대구한의대학교 한의과대학 본초학교실)
Objectives : This study was designed to compare the effects of acanthopanax stem bark (ASB) and acanthopanax root bark (ARB) on the monosodium iodoacetate (MIA)-induced osteoarthritis rats. Methods : The antioxidant activities were evaluated through radical scavenging assays using 2,2'-azino-bis (3-...
핵심어 | 질문 | 논문에서 추출한 답변 |
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DPPH free radical 소거법은 어떠한 목적으로 사용되는가? | 항산화 활성을 측정하는 방법으로 Blosis에 의한 DPPH free radical 소거법을 사용하였다9). 시료 중에 포함된 항산화 물질의 양을 측정하는데 사용되는 대표적인 실험법이다. 일정농 도를 가진 시료 100 ㎕와 60 μM, 그리고 DPPH 용액 100 ㎕를 넣고 혼합한 후, 실온에서 30분 동안 반응시켰다. | |
골관절염이란 무엇인가? | 골관절염 (osteoarthritis)은 연골의 세포외 기질 (extracellular matrix, ECM)의 손상과 연골세포의 소멸 (death of chondrocyte)을 특징으로 하는 퇴행성 질환의 한 종류이다. 골관절염 (osteoarthritis)의 연골 손상 원인은 아직 정확히 밝혀지지 않았으나, IL-1 (interleukin-1)이나 TNF (tumor necrosis factor) 등의 염증 cytokine에 의해 세포외 기질파괴가 촉진되어, 관절 연골의 손상 및 연골세포의 소멸을 야기하여 발생하는 것으로 알려져 있다1). | |
골관절염의 연골 손상 원인으로 어떠한 것이 알려져 있는가? | 골관절염 (osteoarthritis)은 연골의 세포외 기질 (extracellular matrix, ECM)의 손상과 연골세포의 소멸 (death of chondrocyte)을 특징으로 하는 퇴행성 질환의 한 종류이다. 골관절염 (osteoarthritis)의 연골 손상 원인은 아직 정확히 밝혀지지 않았으나, IL-1 (interleukin-1)이나 TNF (tumor necrosis factor) 등의 염증 cytokine에 의해 세포외 기질파괴가 촉진되어, 관절 연골의 손상 및 연골세포의 소멸을 야기하여 발생하는 것으로 알려져 있다1). 현대 사회의 노인인구의 비율 증가에 맞춰, 대표적 노인 질환이라 볼 수 있는 골관절염의 발병 빈도 역시 가파르게 증가하고 있어, 이에 대한 적절한 대책이 필요하다2). |
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