The purpose of this study is to fabricate an ophthalmic lens by copolymerizing two types of carbon nanotubes and hydrophilic hydrogel lens materials, and to investigate its application as an ophthalmic lens material by analyzing its physical properties and antimicrobial effect. For polymerization, H...
The purpose of this study is to fabricate an ophthalmic lens by copolymerizing two types of carbon nanotubes and hydrophilic hydrogel lens materials, and to investigate its application as an ophthalmic lens material by analyzing its physical properties and antimicrobial effect. For polymerization, HEMA (2-hydroxyethyl methacrylate), EGDMA (ethylene glycol dimethacrylate), a crosslinking agent, and AIBN (azobisisobutyronitrile), an initiator, are used as a basic combination, and a single-walled carbon nanotube and a single-walled, carboxylic-acid-functionalized carbon nanotube are used as additives. To analyze the physical properties, the water content, refractive index, breaking strength, and antimicrobial effect of the fabricated lenses are measured. The fabricated lenses satisfies all the basic properties of the basic hydrogel ophthalmic lens. The water content increases with increasing amount of additive and decreases with addition of 0.2 % ratio of nanoparticles. The refractive index is inversely proportional to the water content result. As a result of the antimicrobial test of the fabricated lens, the addition of carbon nanotubes shows an excellent antimicrobial effect. Therefore, it is considered that the fabricated lens can be applied as a functional material for basic ophthalmic hydrogel lenses.
The purpose of this study is to fabricate an ophthalmic lens by copolymerizing two types of carbon nanotubes and hydrophilic hydrogel lens materials, and to investigate its application as an ophthalmic lens material by analyzing its physical properties and antimicrobial effect. For polymerization, HEMA (2-hydroxyethyl methacrylate), EGDMA (ethylene glycol dimethacrylate), a crosslinking agent, and AIBN (azobisisobutyronitrile), an initiator, are used as a basic combination, and a single-walled carbon nanotube and a single-walled, carboxylic-acid-functionalized carbon nanotube are used as additives. To analyze the physical properties, the water content, refractive index, breaking strength, and antimicrobial effect of the fabricated lenses are measured. The fabricated lenses satisfies all the basic properties of the basic hydrogel ophthalmic lens. The water content increases with increasing amount of additive and decreases with addition of 0.2 % ratio of nanoparticles. The refractive index is inversely proportional to the water content result. As a result of the antimicrobial test of the fabricated lens, the addition of carbon nanotubes shows an excellent antimicrobial effect. Therefore, it is considered that the fabricated lens can be applied as a functional material for basic ophthalmic hydrogel lenses.
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제안 방법
coli were identified. By setting the combination with no carbon nanotubes added to HEMA (the basic hydrogel hydrophilic lens material) as the Ref, and C2 and CC2 as the control and experimental groups, respectively, the antimicrobial effects against Staphylococcus aureus and E. coli were examined. The results are shown in Fig.
For polymerization, HEMA, EGDMA, and AIBN were used as a basic combination, and mixtures were prepared by adding the SWCNT and the SWCCNT at each ratio to the basic combination. After vortexing for about 30 minutes, the mixture was evenly dispersed using an ultrasonic disperser (Branson 2510) for about 60 minutes.
13) Therefore, it is judged that the polymer made of carbon nanotubes can be applied to various medical devices by applying biomaterials. In this study, multifunctional hydrogel lenses with mechanical strength and a strong antimicrobial effect were fabricated using carbon nanotubes as an ophthalmic hydrogel contact lens material. The functions of the two carbon nanotubes were also compared, using a single-walled, carboxylicacid-functionalized carbon nanotube, to which carboxylic acid (-COOH) groups were attached, as well as a singlewalled carbon nanotube.
The lenses were fabricated after copolymerization by adding carbon nanotubes to the conventional hydrogel materials, and were analyzed with a scanning electron microscope (SEM) to check the surface status and nanoparticles. The particle size of SWCNT ranges from 80 to 100 nm and the particle size of SWCCNT ranges from 10 to 30 nm, confirming the presence of nanoparticles on the surface.
9 % sodium chloride for 24 hours. Then the optical and physical characteristics, such as the optical transmittance, refractive index, and water content, were evaluated, and the stability was evaluated based on the absorbance and through an extractable test and pH measurement. Lastly, the antimicrobial effect of the fabricated lens was evaluated.
The functions of the two carbon nanotubes were also compared, using a single-walled, carboxylicacid-functionalized carbon nanotube, to which carboxylic acid (-COOH) groups were attached, as well as a singlewalled carbon nanotube. To analyze the physical properties of the fabricated lens polymer, the optical and physical characteristics, including the water content, refractive index, optical transmittance, and breaking strength, were measured. To evaluate the stability of the lens, the absorbance and extractables were measured.
To increase the antimicrobial effect and strength of the hydrogel lens, two types of carbon nanotubes (the SWCNT and the SWCCNT) were added to the conventional hydrogel lens materials at each ratio for copolymerization, and then the physical properties, stability, and antimicrobial effect of the lenses were evaluated. As a result of the addition of 0.
대상 데이터
In this experiment, for HEMA (2-hydroxyethyl methacrylate), which is mainly used as a hydrogel lens material, and AIBN (azobisisobutyronitrile), a radical initiator, the products of JUNSEI were used. For the crosslinking agent, EGDMA (ethylene glycol dimethacrylate) was used, and for the additives, a single-walled carbon nanotube (SWCNT) and a single-walled, carboxylic-acid-functionalized carbon nanotube (SWCCNT), both products of SIGMA-ALDRICH, were used.
이론/모형
The microorganisms were analyzed through the dryrehydratable-film method to measure the antimicrobial effect. 1 ml of the sample solution hydrated in 0.
The water content was measured through the gravimetric method, based on ISO 18369-4:2006, and the refractive index was measured using an ABBE refractometer (ATAGO NAR 1T, Japan). For the results of the measurement of the fabricated samples, the water content of Ref (with no carbon nanotubes added) was 37.
성능/효과
For the spectral transmittance of the lens, the transmittance values of UV-B (280-315 nm), UV-A (315-380 nm), and visible light (380-780 nm) were measured using the Agilent Cary 60 UV-vis. As a result, the average transmittance of Ref with no carbon nanotubes added was about 91.3 % for visible light, 89.7 % for UV-A, and 72.3 % for UV-B. In combination C, where a SWCNT was added at each ratio, the average transmittance was 50-69.
coli and Staphylococcus aureus, regardless of the type of carbon nanotube. Based on the experiment results, it can be said that hydrogel lenses containing carbon nanotubes have a high antimicrobial effect and can be used as an ophthalmic functional contact lens material, in accordance with the physical properties of the conventional hydrogel lens.
The polymerization stability to the hydrogen ion was shown to be excellent in all the groups. The antimicrobial effect of the lenses was improved compared to Ref with regard to both E. coli and Staphylococcus aureus, regardless of the type of carbon nanotube. Based on the experiment results, it can be said that hydrogel lenses containing carbon nanotubes have a high antimicrobial effect and can be used as an ophthalmic functional contact lens material, in accordance with the physical properties of the conventional hydrogel lens.
8. The antimicrobial results showed that there were somewhat more microorganisms in Ref than in the C2 and CC2 groups in both the Staphylococcus aureus and E. coli media, indicating that the bacterial distribution was different between Ref and the groups with carbon nanotubes. Carbon nanotubes are known to be excellent in the antimicrobial properties due to the strong sterilization effect of direct damage to the cell membrane of microorganisms.
참고문헌 (14)
D. H. Kim and A. Y. Sung, J. Korean Chem. Soc., 61, 97 (2017).
M. J. Lee and A. Y. Sung, J. Nanosci. Nanotechnol., 17, 7400 (2017).
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