[논문]Anxiolytic Action of Taurine via Intranasal Administration in Mice

Jung, Jung Hwa; Kim, Sung-Jin

doi:10.4062/biomolther.2018.218

Anxiolytic Action of Taurine via Intranasal Administration in Mice 원문보기

Biomolecules & therapeutics, v.27 no.5, 2019년, pp.450 - 456

Jung, Jung Hwa (Department of Pharmacology and Toxicology and Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee University) , Kim, Sung-Jin (Department of Pharmacology and Toxicology and Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee University)

Abstract ▼ AI-Helper

Taurine has a number of beneficial pharmacological actions in the brain such as anxiolytic and neuroprotective actions. We explored to test whether taurine could be transported to the central nervous system through the intranasal route. Following intranasal administration of taurine in mice, elevated plus maze test, activity cage test and rota rod test were carried out to verify taurine's effect on anxiety. For the characterization of potential mechanism of taurine's anti-anxiety action, mouse convulsion tests with strychnine, picrotoxin, yohimbine, and isoniazid were employed. A significant increase in the time spent in the open arms was observed when taurine was administered through the nasal route in the elevated plus maze test. In addition, vertical and horizontal activities of mice treated with taurine via intranasal route were considerably diminished. These results support the hypothesis that taurine can be transported to the brain through intranasal route, thereby inducing anti-anxiety activity. Taurine's anti-anxiety action may be mediated by the strychnine-sensitive glycine receptor as evidenced by the inhibition of strychnine-induced convulsion.

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제안 방법

Activity cage tests are another widely accepted as an experimental tool to test anti-anxiety actions of drugs. Following taurine administration (200 mg/kg, IN), mice were delivered to the activity cage for 4 min, and evaluated for horizontal and vertical activities. Taurine treatment caused a decrease in the horizontal steps by 43%, and it also diminished the vertical steps by 81% as compared to controls (Fig.
To evaluate taurine’s potential effect on the memory formation, passive avoidance test was carried out.

대상 데이터

Groups of 10 mice with a weight between 35 and 40 g were used. They were treated intranasally with saline or taurine (200 mg/kg, IN).
Picrotoxin-Induced convulsions Groups of 10 mice with a weight between 35 and 40 g were used. They were treated intranasal with distilled water or taurine (200 mg/kg, IN).

데이터처리

0 software (GraphPad Software, San Diego, CA, USA). Analysis of a non-parametric unpaired t-test were used. The differences were considered statistically significant at p<0.

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