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NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.35 no.4, 2020년, pp.51 - 60
김상우 (경희대학교 한의과대학 해부학교실) , 홍수연 (경희대학교 한의과대학 해부학교실) , 권보근 (경희대학교 한의과대학 해부학교실) , 김명현 (경희대학교 한의과대학 해부학교실) , 김상배 (경희대학교 한의과대학 해부학교실) , 진대환 (경희대학교 한의과대학 해부학교실) , 최우찬 (경희대학교 한의과대학 해부학교실) , 손영주 (경희대학교 한의과대학 해부학교실) , 정혁상 (경희대학교 한의과대학 해부학교실)
Objective : The objective of this study was to demonstrate the effect of Persicae Semen (PS) in DNCB-induced atopic dermatitis mouse and HaCaT cell. Methods : The BALB/c mice were divided into four groups. To develop atopic dermatitis, 200 ㎕ of 1 and 0.5% DNCB solution was put on the back of ...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
桃仁(도인)은 무엇인가? | 桃仁은 장미과(Rosaceae) 식물인 복사나무 Prunus persica (L.) Batsch 또는 산복사나무 P. davidiana (Carr.) Franch의 성숙한 과실에서 과육, 씨앗, 껍질을 제거하고 種仁만 취하여 건조한 것(Persicae Semen)이다24) . 성분은 amygdalin을 약 1. | |
최근 밝혀진 桃仁의 효능은 무엇이 있는가? | 」으로 기재된 生血潤膚飮 35) 과 腎臟風瘡痒痛에 사용하는 活血驅風散35) 이 대표적이고, 生血潤膚飮의 경우에는 항알러지 효과36) 와 아토피 피부염에 대한 임상 효과37) 에 대한 연구결과가 보고되었다. 최근 연구에 의하면 桃仁 추출 성분이 알러지 염증을 억제하고38) , 주성분인 amygdalin은 피부각질형성세포 (keratinocyte cell)에 대한 면역조절 효과가 보고되어 39) , 이상의 내용을 고려하면 桃仁이 아토피 피부염에서 염증을 완화할 수 있는 가능성이 있을 것으로 판단하였다. | |
아토피 피부염 환자에게 발견되는 특이 IgE 증가로 인한 과민반응의 과정은 무엇인가? | 아토피 피부염 환자는 유전적으로 결함이 있는 피부 장벽을 가지므로 보통 사람과 달리 병변이 없는 피부라도 정상적이지 않고 아토피 피부염 급성 반응은 랑게르한스 세포에 의해 매개된다52) . 알레르겐에 노출되어 IgE와 랑게르한스세포에 있는 Fcε 수용 체가 결합하면 랑게르한스세포는 CD4+ T세포를 피부로 유도 하는 IL-16과 단핵구 화학주성 단백을 생산하고 기억 Th2 세포를 활성화하며 항원을 T세포에 제시하여 민감화 시키고 림프절로 이동하여 naive T 세포 (Th0 세포)가 Th2 세포로 분화되도록 촉진한다. 병터로 이동한 단핵구는 Inflammatory dendritic epidermal cells (IDEC)로 분화하고 전구염증성 사이토카인인 IL-1, IL-6, TNF-α를 분비한다. 민감화된 Th2 세포는 IL-4, 5, 13과 같은 사이토카인을 생산하며, 이들은 면역 글로블린 동종형을 IgE로 전환시켜 Th2 세포의 생존을 촉진하고, 전환된 IgE는 알레르겐 반응을 증폭시켜 양성 되먹임(positive feedback) 고리를 형성한다. 이러한 Th2 면역반응과 면역반응의 증폭은 아토피 피부염의 초기 병변 생성에 중요한 역할을 한다47) . |
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