[논문]비만, 폐쇄성 수면무호흡증과 대사장애

김진관; 표상신; 윤대위

doi:10.15324/kjcls.2021.53.4.285

[국내논문] 비만, 폐쇄성 수면무호흡증과 대사장애
Obesity, Obstructive Sleep Apnea, and Metabolic Dysfunction 원문보기

Korean journal of clinical laboratory science : KJCLS = 대한임상검사과학회지, v.53 no.4, 2021년, pp.285 - 295

김진관 (중원대학교 임상병리학과) , 표상신 (중원대학교 임상병리학과) , 윤대위 (중원대학교 임상병리학과)

초록
AI-Helper

수면은 필수적인 생리적 기능일 뿐만 아니라 인간의 성장, 성숙 및 전반적인 건강을 증진시키는 데 중요한 역할을 한다. 수면과 수면 장애가 대사성 질환에 미치는 영향에 대한 관심이 높아지고 있다. 폐쇄성 수면무호흡증은 일반적인 건강 문제이며, 지난 10년 동안 비만율의 증가로 인해 더 두드러진 대사 질환과 함께 폐쇄성 수면무호흡증의 유병률이 현저하게 증가했다. 폐쇄성 수면무호흡증에 의한 대사성 질환을 유발하는 근본적인 메커니즘은 다인성일 가능성이 높으며, 완전히 밝혀지지 않고 있지만, 염증과 산화 스트레스의 활성화와 식욕 조절 호르몬의 조절 장애는 폐쇄성 수면무호흡증 환자에게 나타나는 대사 기능 장애와 비만의 중요한 병리 생리학적 성분으로 나타났다. 본 연구에서는 폐쇄성 수면무호흡증과 대사질환의 연관성에 대한 연구 현황과 폐쇄성 수면무호흡증이 이러한 질병을 유발하는 병리생리학적 메커니즘에 대해 검토하고자 한다. 이를 통해 폐쇄성 수면무호흡증과 비만, 그리고 폐쇄성 수면무호흡증과 대사 기능 장애 사이의 잠재적인 상호작용을 이해할 수 있다.

Abstract ▼ AI-Helper

Sleep plays an important role in maintaining overall human health. There is increasing interest regarding the impact of sleep related disorders on metabolic diseases. Obstructive sleep apnea (OSA) is a common health problem, and in the last decade, the emergence of increasing obesity rates has further led to a remarkable increase in the prevalence of OSA, along with more prominent metabolic diseases. Obesity is the strongest risk factor for OSA. However, OSA is also known to cause obesity, suggesting an interaction between OSA and obesity. Although the underlying mechanisms leading to OSA-induced metabolic diseases are probably multi-factorial and are yet to be fully elucidated, the activation of inflammation and oxidative stress and the dysregulation of appetite-regulating hormones have emerged as important pathophysiological components of metabolic dysfunction and obesity observed in patients with OSA. Here, we will review the current state of research regarding the association of OSA with metabolic diseases and the possible pathophysiological mechanisms by which OSA could lead to such diseases. This will enhance our understanding of the potential interactions between OSA and obesity and between OSA and metabolic dysfunction.

Keyword

표/그림 (2)

표 Table 1. Changes in oxidative stress markers, inflammatory substances, and metabolism-related hormones in OSA patients and intermittent hypoxic models
그림 Figure 1. Pathophysiological mechanisms of obesity, glucose and lipid metabolism abnormalities caused by obstructive sleep apnea [90]. Abbreviations: CRP, c-reactive protein; CVD, cardiovascular disease; IL-6, interleukin-6; OSA, obstructive sleep apnea; ROS, reactive oxygen species; TNF-α, tumor necrosis factor-α.

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Kheirandish-Gozal L, Capdevila OS, Tauman R, Gozal D. Plasma c-reactive protein in nonobese children with obstructive sleep apnea before and after adenotonsillectomy. J Clin Sleep Med. 2006;2:301-304.

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Guilleminault C, Kirisoglu C, Ohayon MM. C-reactive protein and sleep-disordered breathing. Sleep. 2004;27:1507-1511. https://doi.org/10.1093/sleep/27.8.1507

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Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated c-reactive protein levels in overweight and obese adults. Jama. 1999;282:2131-2135. https://doi.org/10.1001/jama.282.22.2131

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Htoo AK, Greenberg H, Tongia S, Chen G, Henderson T, Wilson D, et al. Activation of nuclear factor kappab in obstructive sleep apnea: a pathway leading to systemic inflammation. Sleep Breath. 2006;10:43-50. https://doi.org/10.1007/s11325-005-0046-6

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활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
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표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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