[논문]유전학을 이용한 사상의학 임상연구 동향 분석

박준형; 박지은; 이슬; 이용재; 이정윤

doi:10.7730/jscm.2021.33.3.72

유전학을 이용한 사상의학 임상연구 동향 분석
Clinical Research Trends in Sasang Constitutional Medicine Using Genetics 원문보기

JSCM : Journal of Sasang constitutional medicine, v.33 no.3, 2021년, pp.72 - 86

박준형 (부산대학교 한의학전문대학원) , 박지은 (부산대학교 한의학전문대학원) , 이슬 (부산대학교 한의학전문대학원) , 이용재 (부산대학교 한의학전문대학원 임상의학4교실 사상체질과) , 이정윤 (부산대학교 한의학전문대학원 임상의학4교실 사상체질과)

Abstract ▼ AI-Helper

Objectives The aim of this study was to review the current clinical Sasang constitutions studies by using genetics and to provide basic data for developing in a better direction of research. Methods Research articles on genetics of the clinical Sasang constitutions studies were extracted from six databases. The articles were classified were published year, published journals, and the types of studies. Subjects of research and experimental methods for the genetic research were summarized. Results A total of 43 selected research articles were published from 1996 to 2020 and more than half of them were published in Journal of Sasang Constitutional Medicine and Journal of Korean Oriental Medicine. There were three main types of researches. The three types of researches were for investigating a genetic indicator for classification of Sasang constitutional type, confirming a relationship between pathological gene and Sasang constitutional type, and checking a hereditary of Sasang constitutional type. But these studies did not yield clear results illustrating a relationship between Genetics and Sasang Constitutional Medicine. Discussion In this study, the necessity of the follow up studies to demonstrate a relationship between Genetics and Sasang Constitutional Medicine was confirmed.

주제어

표/그림 (4)

그림 Figure 1. Flowchart for the article selection process
그림 Figure 2. The number of articles published per years
그림 Figure 3. The number of articles published in journals
표 Table 1. Clinical Studies by Using Genetics in Sasang Constitutional Medicine

참고문헌 (49)

Bae NY, Lee EJ. Clinical practice guideline for Sasang constitutional medicine: prevention and risk fators of sasangin disease. J Sasang Constitut Med. 2015;27(1):82-109. (Korean) DOI: https://doi.org/10.7730/JSCM.2015.27.1.082

원문보기 상세보기
Dep. of Sasang Constitutional Med. All colleges of Korean Med. in Korea(compilation). The revised and enlarged Sasang Constitutional Med. Seoul: Jipmoondang. 2012. (Korean)
Sohn KW, Jeong AS, Yoon MY, Lee SK, Hwang SM, Chae H. Genetic Characteristics of Sasang Typology: A Systematic Review. J Acupunct Meridian Stud. 2012;5(6):271-89. DOI: https://doi.org/10.1016/j.jams.2012.06.001.

상세보기
Cho DW, Lee CS, Ko BH, Cho HS. Genetic analysis study of sasang constitution classification by DNA-fingerprinting methods. J Sasang Constitut Med. 1996;8(2):151-163. (Korean)
Cho DW, Ahn SK, Ki DK, Kim DW, Ji SE, Lee EJ, et al. Genetic analysis of Sasang constitution by Amp-FLP method. J Sasang Constitut Med. 1997;9(2):163-173. (Korean)
Choi SH, Yim YB, Rhee JW, Kim HY, Kang CH. Relationship between the Sasang constitution and ACE polymophism. J Sasang Constitut Med. 1998;10(2):283-290. (Korean)
Kim DY, Lee JW, Kim DR. Statistical study on heredity in Sasang constitutional medicine. J Sasang Constitut Med. 1999;11(1):159-168. (Korean)
Kim MH, Kim KS, Chi SE, Choi SM, Cho DW. Study on Sasang constitution by genetic analysis using four short tandem repeat loci. J Sasang Constitut Med. 1999;11(1):169-183. (Korean)
Lee HC, Cho DW, Cho JH, Seo YW, Lee CS. A Study on Genetic Relationship between Sasang Constitutions by the Polymorphic Analysis of RAPD. J Korean Oriental Med. 2000;20(4):62-68. (Korean)
Kwon TB, Whang CW, Sul IC, Lee KO, Hwang KY, Yang DH et al. A study of HLA-DR polymorphism in four physical constitution groups classified by Korean traditional medicine. Korean J Med. 2000;58(1):91-101. (Korean)
Han SK, Chi SE, Choi SM. Study on the analysis of constitutional genes by HLA typing. J Sasang Constitut Med. 2001;13(1):97-103. (Korean)
Song I, Lee S. Research of genetic polymorphisms of Sasang Constitution-focusing on SNP of MTHFR gene. J Sasang Constitut Med. 2001;13(2):177-181. (Korean)
Kim SD, Kim MY, Lee SY, Shin BC, Kwon YD, Song YS. Studies on the Relationship between Obesity and Polymorphism in Angiotensin Convertting Enzyme Gene. J Oriental Rehab Med. 2002;12(4):18-29. (Korean)
Kim JK, Han BS, Kim KY, Go GD, Ok YY. Interrelationships among glutathione S-transferase polymorphisms, cerebrovascular disease and Sasang constitution. J Sasang Constitut Med. 2002;14(1):123-131. (Korean)
Bae YC, Kweon DY, Kim KY, Kim IH, Ju JC. Angiotensin converting enzyme (ACE) gene polymorphism and Sasang constitution in patients with cerebral infarction. J Sasang Constitut Med. 2002;14(1):132-139. (Korean)
Koh BH, Song IB, Ha MS. A study on the correlation between Sasang constitution and HLA type. J Sasang Constitut Med. 2002;14(1):90-99. (Korean)
Kim HJ, Hong JM, Yoon YS, Koh BH, Choi SM, Kim SH. A study on the correlation between Sasang constitution and IL-4 polymorphism. J Sasang Constitut Med. 2002;14(2):98-105. (Korean)
Lee SJ, Song IB, Lee SK. Genetic polymorphism of ADPRT gene 3'UTR region and sasang constitution. J Sasang Constitut Med. 2002;14(2): 90-97.
Han JS, Lee MJ. Correlation between ACE Genotype and Cardiopulmonary Endurance by Sasang Constitution Styles in Korean Middle-aged Women. J Oriental Rehab Med. 2002;12(2):12-10. (Korean)
Han SK, Chi SE, Choi SM. A study on the analysis of constitutional genes. J Sasang Constitut Med. 2003;15(1):109-117. (Korean).
Um JY, Kim JK, Joo JC, Kim KY, Hong SH, Kim HM. Gene-gene interaction in cerebral infarction patients: Relationship between apolipopreotein E gene polymorphism and Sasang-con stitution. Orient Pharm Exp Med. 2004;4(2): 104-111. DOI: https://doi.org/10.3742/OPEM.2004.4.2.104

원문보기 상세보기
Um JY, Ok YY, Joo JC, Kim KY, Kim NY Hong SH et al. Glutathione S-transferase polymorphisms and traditional classification in Korean population with cerebrovascular disease. Orient Pharm Exp Med. 2004;4(2):112-119. DOI: https://doi.org/10.3742/OPEM.2004.4.2.112

원문보기 상세보기
Park HS, Kim KY, Joo JC, Kim JY. Study on the Relationship between Candidate Genes of Cerebral Infarction and Sasang Constitution. J Korean Oriental Med. 2004;25(4):209-219. DOI: https://doi.org/10.7783/KJMCS.2017.25.4.209

원문보기 상세보기
Lee SK, Lee SJ. Genetic polymorphism of CCK promotor region and Sasang constitution. J Korean Oriental Med. 2004;25(3):105-110. (Korean)
Yoo HR, Lim JS, Kim YS, Seol IC. Understanding of Sasang Constitutions using DNA chip Analysis. J Korean Oriental Med. 2004;25(1): 72-84. (Korean)
Lee JH, Joo JC, Kim KY, Lee SM, Yoo GS, Ko KD, et al. A Study on the Association between Tumor Necrosis Factor Alpha Gene Polymorphism and Sasang Constitution in Cerebral Infarction. J Korean Oriental Med. 2005;26(1):59-70. DOI: https://doi.org/10.22722/KJPM.2018.26.1.59

원문보기 상세보기
Kim JW, Seo JC, Jung TY. Genetic polymorphism of interleukin 10 gene and Sasang constitution in Bell's palsy patients. Korean J Oriental Physiol Pathol. 2005;19:515-519.
Lee JH, Seo BY, Han SY, Yeom SR, Lee SK, Kwon YD, et al. Study on Relationship between Interleukin-1 Beta Gene Polymorphism and Sasang Constitution in Korean Obese Women. J Oriental Rehab Med. 2005;15(3):127-137.
Song JS, Kwon YD, Kim SJ, Lee SK, Yeom SR, Song YS. Association between Interleukin-1α Polymorphism-889C/T and Sasang Constitution in Korean Obese Women. J Oriental Rehab Med. 2005;15(1):67-75.
Lee BC, Ahn YM, Ahn SY, Doo HK. Susceptibility for ischemic stroke in Sasang constitutional classification is associated with the interleukin-1 receptor antagonist polymorphism. Orient Pharm Exp Med. 2006;6(1):27-33. DOI: https://doi.org/10.3742/OPEM.2006.6.1.027

원문보기 상세보기
Kim PJ, Seo EH, Lee JH, Ha JH, Choi HS, Jung TY, et al. A Study on Sasang Constitutional Gene Selection Using DNA Chips by Multivariate Analysis. J Sasang Constitut Med. 2006;18(3): 131-144. (Korean)
Lee BC, Doo HK, Ahn SY, Byun SH, Kim SI, Hong M, et al. Peroxisome proliferator-activated receptor-γ Pro12Ala polymorphism is associated with the susceptibility to ischemic stroke in Taeeumin classified by Sasang medicine. Neurol Res. 2007;29(sup1):32-37. DOI: https://doi.org/10.1179/016164107X172347

상세보기
Kim SY, Jeon HJ, Lee DI, Lee YH, Choi DY, Yoo YK, et al. A Study of TNF-α(308) Genetic Polymorphism and Risk Factors Associated with Rheumatoid Arthritis by Sasang Constitution. J Acupunct Res. 2007;24(1):137-159. (Korean)
Lee SK, Kim HJ, Park HJ, Lee JH, Kwon DY, Joo JC, et al. Association between Genetic Polymorphisms of the CYP2C19, CYP2D6 and Types of Sasang Constitutional Medicine. J Korean Oriental Med. 2007;28(1):51-62. (Korean) DOI: https://doi.org/10.4266/kjccm.2013.28.1.51

상세보기
Won HH, Lee SW, Jang ES, Kim KK, Park YK, Kim YJ et al. A genome-wide scan for the sasang constitution in a korean family suggests significant linkage at chromosomes 8q11. 22-23 and 11q22. 1-3. The J Altern Complement Med. 2009;15(7):765-769. DOI: https://doi.org/10.1089/acm.2009.0067

상세보기
Kim HJ, Hwang SY, Kim JH, Park HJ, Lee SG, Lee SW, et al. Association between genetic poly morphism of multidrug resistance 1 gene and sasang constitutions. J Evid Based Integr Med. 2009;6(S1):73-80. DOI: https://doi.org/10.1093/ecam/nep118

상세보기
Yin CS, Park HJ, Chung JH, Lee HJ, Lee BC. Genome-wide association study of the four-constitution medicine. The J Altern Complement Med. 2009;15(12):1327-1333. DOI: https://doi.org/10.1089/acm.2009.0205

상세보기
Park HY, Yu HJ, Ku IH, Kim JY. Short tandem repeat allele frequencies in Sasang constitution. J Sasang Constitut Med. 2009;21(1):227-236. (Korean)
Cha SW, Koo IH, Park BL, Jung SK, Choi SM, Kim KS, et al. Genetic effects of FTO and MC4R polymorphisms on body mass in constitutional types. J Evid Based Integr Med. 2011;2011. DOI: https://doi.org/10.1093/ecam/nep162

상세보기
Song KH, Yu SG, Cha SW, Kim JY. Association of the apolipoprotein A5 gene- 1131T> C polymorphism with serum lipids in Korean subjects: impact of Sasang constitution. J Evid Based Integr Med. 2012;2012. DOI: https://doi.org/10.1155/2012/598394

상세보기
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상세보기
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상세보기
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상세보기
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상세보기
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원문보기 상세보기
Kim SH, Lee SW, Lee JH, Lee EJ. Clinical Practice Guideline for Sasang Constitutional Medicine: The ex- amination of Sasangin disease and diagnosis for Sasang constitution. J Sasang Constitut Med. 2015;27(1):110-124. (Korean) DOI: https://doi.org/10.7730/JSCM.2015.27.1.110

원문보기 상세보기
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