[논문]동시 PET-MRI를 위한 N-(p-maleimidophenyl) isocyanate linker-매개 합성을 이용한 복합 조영제의 평가

이길재; 이훈재; 이태수

doi:10.7742/jksr.2022.16.2.103

동시 PET-MRI를 위한 N-(p-maleimidophenyl) isocyanate linker-매개 합성을 이용한 복합 조영제의 평가
Evaluation of Combined Contrast Agent using N-(p-maleimidophenyl) Isocyanate Linker-mediated Synthesis for Simultaneous PET-MRI 원문보기

한국방사선학회 논문지 = Journal of the Korean Society of Radiology, v.16 no.2, 2022년, pp.103 - 113

이길재 (충북대학교 대학원 의용생체공학과) , 이훈재 (연세대학교 의과대학 영상의학과) , 이태수 (충북대학교 대학원 의용생체공학과)

초록
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이 논문에서는 결합된 PET(fluorodeoxyglucose, ¹⁸F-FDG)와 MRI(magnetic nanoparticles, MNP) 조영제를 동시 PET-MRI 스캔에 사용하기 위한 가교제로 N-(p-maleimidophenyl) isocyanate를 사용하여 합성하는 방안을 제안하였다. 실험은 신경교종 줄기 세포 마우스 모델에서 결합 조영제(¹⁸F-FDG로 표지된 MNP)를 주입하기 전후에 PET-MRI 이미지를 획득하고 평가하였다. 획득한 각 영상에 대해 관심영역(ROI)을 설정한 후, 분할하여 병변의 면적을 계산하였을 때 PET 영상이 MRI 영상보다 더 크고 정확했다. 특히 동시 PET-MRI 영상은 주변 연조직과 함께 정확한 병변을 묘사하였다. 평균 및 표준편차 값은 조영제 주입 여부에 관계없이 PET 영상 또는 PET-MRI 동시 영상보다 MRI 단독 영상에서 더 높게 나타났다. 또한 동시 PET-MRI 영상값이 PET 영상보다 평균 및 표준편차 값이 높게 나타났다. ¹⁸F-FDG 라벨링된 MNP 조영제와 동시 PET-MRI 영상을 표적 영상으로 사용하고 ¹⁸F- FDG 조영제만을 원본 이미지로 사용했을 때의 피크 신호 대 잡음비(PSNR) 값은 모든 실험에서 유의미 하게 나타났다. 결론적으로 동시 PET-MRI 영상에서 결합된 ¹⁸F-FDG 표지 MNP 조영제가 유용함을 확인하였다. 다양한 핵종을 사용할 수 있는 SPECT-MRI 영상 연구를 통해 진단과 치료를 동시에 할 수 있는 제제를 개발하기 위해서는 향후 연구가 필요할 것이다.

Abstract ▼ AI-Helper

In this paper, a combined 18F-FDG(fluorodeoxyglucose) and MNP(magnetic nanoparticles) contrast agent was synthesized using N-(p-maleimidophenyl) isocyanate as the crosslinker for use in simultaneous PET-MRI scans. PET-MRI images were acquired and evaluated before and after injection of the combined contrast imaging agent (18F-FDG labeled MNP) from a glioma stem cell mouse model. After setting the region of interest (ROI) on each acquired image, the area of the lesion was calculated by segmentation. As a result, the PET image was larger than the MRI. In particular, the simultaneous PET-MRI images showed accurate lesions along with the surrounding soft tissue. The mean and standard deviation values were higher in the MRI images alone than in the PET images or the simultaneous PET-MRI images, regardless of whether the contrast agent was injected. In addition, the simultaneous PET-MRI image values were higher than for the PET images. For PSNR experiments, the original image was PET Image using 18F-FDG, MRI using MNPs, and MRI without contrast medium, and the target image was simultaneous PET-MRI image using 18F-FDG labeled MNPs contrast medium. As a result, all of them appeared significantly, suggesting that the 18F-FDG labeled MNPs contrast medium is useful. Future research is needed to develop an agent that can simultaneously diagnose and treat through SPECT-MRI imaging research that can use various nuclides.

주제어

표/그림 (16)

그림 Fig. 1. Simultaneous Multiparametric PET/MRI.
그림 Fig. 2. ¹⁸F-FDG labeled MNPs.
그림 Fig. 3. Example of M-programing for image evaluation.
그림 Fig. 4. Flow-chart of the experimental process.
표 Table 1. Image acquisition via the simultaneous PET-MRI device
표 Table 2. Mean value and standard deviation of experimental images
표 Table 3. Simultaneous PET-MRI (18F-FDG labeled MNP contrast agent) image processing
표 Table 4. PET (¹⁸F-FDG contrast agent) image processing
표 Table 5. MRI (MNP contrast agent) image processing
표 Table 6. MRI (no contrast agent) image processing
표 Table 7. Results of PSNR between PET (¹⁸F-FDG) and PET-MRI (¹⁸F-FDG labeled MNP)
표 Table 8. Results of PSNR between MRI (MNP) and PET-MRI (¹⁸F-FDG labeled MNP)
표 Table 9. Results of PSNR between MRI (no contrast agent) and PET-MRI (¹⁸F-FDG labeled MNP)
표 Table 10. Area comparison of the lesion site
그림 Fig. 5. Mean value and standard deviation for each pixel of experimental images.
그림 Fig. 6. PSNR values of the simultaneous PET-MRI image using the ¹⁸F-FDG labeled MNP contrast agent.

AI 본문요약
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성능/효과

1) PSNR was calculated using simultaneous PET-MRI images (18F-FDG labeled MNP) as the target image and PET images (18F-FDG) as the original image.
5 shows the average value and standard deviation of the signal for each experimental image. The mean and standard deviation values were higher for the MRI images than both the PET or simultaneous PET-MRI images, regardless of whether contrast agents were used, and simultaneous PET-MRI images were higher than PET images. These results indicate that MRI is an imaging device with a high signal-to-noise ratio(SNR).

참고문헌 (30)

D. W. Townsend, T. Beyer, T. M. Blodgett, "PET/CT scanners: A hardware approach to image fusion", Seminars in Nuclear Medicine, Vol. 33, No. 3, pp. 193-204, 2003. http://dx.doi.org/10.1053/snuc.2003.127314

상세보기
D. W. Townsend, J. P. J. Carney, J. T. Yap, N. C. Hall, "PET/CT today and tomorrow", Journal of Nuclear Medicine, Vol. 45, pp. 4-14, 2004.

상세보기
Y. Shao, S. R. Cherry, K. Farahani, K. Meadors, S. Siegel, R. W. Silverman, P. K. Marsden, "Simultaneous PET and MR imaging", Physics in Medicine And Biology, Vol. 42, No. 10, pp. 1965-1970, 1997. http://dx.doi.org/10.1088/0031-9155/42/10/010

상세보기
J. E. Mackewn, D. Strul, W. A. Hallett, P. Halsted, R. A. Page, S. F. Keevil, S. C. R. Williams, S. R. Cherry, P. K. Marsden, "Design and development of an MR-compatible PET scanner for imaging small animals", IEEE transactions on nuclear science, Vol. 52, No. 5, pp. 1379-1380, 2005. http://dx.doi.org/10.1109/TNS.2005.858260

상세보기
H. Zaidi, A. D. Guerra, "An outlook on future design of hybrid PET/MRI systems", Medical Physics, Vol. 38, No. 10, pp. 5667-5689, 2011. http://dx.doi.org/10.1118/1.3633909

상세보기
J. F. Valliant, "A bridge not too far: Linking disciplines through molecular imaging probes", Journal of Nuclear Medicine, Vol. 51, No. 8, pp. 1258-1268, 2010. http://dx.doi.org/10.2967/jnumed.109.068312

상세보기
R. Weissleder, M. J. Pittet, "Imaging in the era of molecular oncology", Nature, Vol. 452, No. 7187, pp. 580-589, 2008. https://doi.org/10.1038/nature06917

상세보기
T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, "A combined PET/CT scanner for clinical oncology", Journal of Nuclear Medicine, Vol. 41, No. 8, pp. 1369-1290, 2000.

상세보기
B. J. Pichler, A. Kolb, T. Nagele, H. P. Schlemmer, "PET/MRI: Paving the way for the next generation of clinical multimodality imaging applications", Journal of Nuclear Medicine, Vol. 51, No. 3, pp. 333-336, 2010. http://dx.doi.org/10.2967/jnumed.109.061853

상세보기
H. Zaidi, M. L. Montandon, A. Alavi, "The clinical role of fusion imaging using PET, CT, and MR imaging", Magnetic Resonance Imaging Clinics of North America, Am. Vol. 18, No. 1, pp. 133-149, 2010. https://doi.org/10.1016/j.mric.2009.09.010

상세보기
G. J. Lee, Fitting Map Analysis of Simultaneous MR-PET Images by Artificial Intelligence, Nambu University Graduate School of Radiology Master's Thesis, pp. 4-9, 2020.
R. R. Raylman, S. Majewski, S. K. Lemieux, S. S. Velan, B. Kross, V. Popov, M. F. Smith, A. G. Weisenberger, C. Zorn, G. D. Marano, "Simultaneous MRI and PET imaging of a rat brain", Physics In Medicine And Biology. Vol. 51, No. 24, pp. 6371-6379, 2006. http://dx.doi.org/10.1088/0031-9155/51/24/006

상세보기
Z. Cheng, A. A. Zaki, J. Z. Hui, V. R. Muzykantov, A. Tsourkas, "Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities", Science, Vol. 338, No. 6109, pp. 903-910, 2012. http://dx.doi.org/10.1126/science.1226338

상세보기
E. F. Craparo, M. L. Bondi, G. Pitarresi, G. Cavallaro, "Nanoparticulate Systems for Drug Delivery and Targeting to the Central Nervous System", CNS: Neuroscience and Therapeutics, Vol. 17, No. 6, pp. 670-677, 2011. http://dx.doi.org/10.1111/j.1755-5949.2010.00199.x

상세보기
L. Chen, W. Hong, W. Ren, T. Xu, Z. Qian, Z. He, "Recent progress in targeted delivery vectors based on biomimetic nanoparticles", Signal Transduction and Targeted Therapy, Vol. 6, pp. 1-25, 2021. http://dx.doi.org/10.1038/s41392-021-00631-2

상세보기
L. Cunha, I. Horvath, S. Ferreira, J. Lemos, P. Costa, D. Vieira, D. S. Veres, K. Szigeti, T. Summavielle, D. Mathe, L. F. Metello, "Preclinical Imaging: an Essential Ally in Modern Biosciences", Molecular Diagnosis & Therapy, Vol. 18, No. 2, pp. 153-173, 2014. http://dx.doi.org/10.1007/s40291-013-0062-3

상세보기
M. Swierczewska, S. Lee, X. Chen, "Inorganic Nanoparticles for Multimodal Molecular Imaging", Molecular Imaging, Vol. 10, No. 1, pp. 3-16, 2011. http://dx.doi.org/10.2310/7290.2011.00001

상세보기
J. C. Patrick, Developments in PET-MRI for Radiotherapy Planning Applications, Electronic Thesis and Dissertation Repository. 4535, 2017. https://ir.lib.uwo.ca/etd/4535
A. Hervault, N. T. K. Thanh, "Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer", Nanoscale, Vol. 6, No. 20, pp. 11553-11573, 2014. http://dx.doi.org/10.1039/C4NR03482A

상세보기
Y. Hu, L. Meng, L. Niu, Q. Lu, "Highly cross-linked and biocompatible polyphosphazene-coated superparamagnetic Fe3O4 nanoparticles for magnetic resonance imaging", Journal of the American Chemical Society, Vol. 29, pp. 9156-9163, 2013. http://dx.doi.org/10.1021/la402119s

상세보기
S. Purushotham, P. E. J. Chang, H. Rumpel, I. H. C. Kee, R. T. H. Ng, P. K. H. Chow, C. K. Tan, R. V. Ramanujan, "Thermoresponsive core-shell magnetic nanoparticles for combined modalities of cancer therapy", Nanotechnology, Vol. 20, No. 30, pp. 305101, 2009. http://dx.doi.org/10.1088/0957-4484/20/30/305101

상세보기
H. Hermessi, O. Mourali, E. Zagrouba, "Multimodal medical image fusion review: Theoretical background and recent advances", Signal Processing, Vol. 183, pp. 108038, 2021. https://doi.org/10.1016/j.sigpro.2021.108036

상세보기
L. Ma, W. Lin, C. Deng, K. N. Ngan, "Image retargeting quality assessment: a study of subjective scores and objective metrics", IEEE Journal of Selected Topics in Signal Processing, Vol. 6, No. 6, pp. 626-639, 2012. http://dx.doi.org/10.1109/JSTSP.2012.2211996

상세보기
L. Ma, S. Li, F. Zhang, K. N. Ngan, "Reduced-reference image quality assessment using reorganized DCT-based image representation", IEEE Transactions on Multimedia, Vol. 13, No. 4, pp. 824-829, 2011. http://dx.doi.org/10.1109/TMM.2011.2109701

상세보기
Mredhula. L, M. A. Dorairangaswamy, "An Extensive Review of Significant Researches on Medical Image Denoising Techniques", International Journal of Computer Applications, Vol. 64. No. 14, pp. 0975-8887, 2013. http://dx.doi.org/10.5120/10699-1551
K. S. Kang, J, H. Lee, "PSNR Appraisal of MRI Image", Journal of the Korean Society of Radiology, Vol. 3, No. 4, pp. 13-21, 2009.
S. C. Chan, C. H. Yeh, T. C. Yen, S. H. Ng, J. T. C. Chang, C. Y. Lin, Y. M. Tsang, K. H.Fan, B. S. Huang, C. L. Hsu, K. P. Chang, H. M Wang, C. T. Liao, "Clinical utility of simultaneous whole-body 18F-FDG PET/MRI as a single-step imaging modality in the staging of primary nasopharyngeal carcinoma", European Journal of Nuclear Medicine and Molecular Imaging, Vol. 45, No. 8, pp. 1297-1308, 2018. http://dx.doi.org/10.1007/s00259-018-3986-3

상세보기
Mohammad Reza Hayeri, Pouya Ziai, Monda L Shehata, Oleg M Teytelboym, Brady K Huang, "Soft-Tissue Infections and Their Imaging Mimics: From Cellulitis to Necrotizing Fasciitis", Radiographics :a review publication of the Radiological Society of North America, Inc, Vol. 36, No. 6, pp. 1888-1910, 2016. http://dx.doi.org/10.1148/rg.2016160068

상세보기
J. I. Kim, I. S. Kim, H. J. Lee, J. E. Kim, "Effect of MRI Media Contrast on PET/MRI", The Korean Journal of Nuclear Medicine Technology, Vol. 18, No. 1, pp. 19-25, 2014.
M. Hofmann, I. Bezrukov, F. Mantlik, P. Aschoff, F. Steinke, T. Beyer, B. J. Pichler, B. Scholkopf, "MRI-based attenuation correction for whole-body PET/MRI: quantitative evaluation of segmentationand atlas-based methods", Journal of Nuclear Medicine, Vol. 52, No. 9, pp. 1392-1399, 2011. http://dx.doi.org/10.2967/jnumed.110.078949

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