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계피(Cinnamomum cassia Presl) 추출물과 cinnamaldehyde의 alcohol dehydrogenase 저해 효과
Inhibitory effect of cinnamon (Cinnamomum cassia Presl) extract and cinnamaldehyde on alcohol dehydrogenase 원문보기

Journal of applied biological chemistry, v.65 no.3, 2022년, pp.183 - 187  

도재호 (Korea Ginseng MFG Co., Ltd) ,  인만진 (Department of Chemical Engineering, Chungwoon University) ,  김동청 (Department of Chemical Engineering, Chungwoon University)

초록
AI-Helper 아이콘AI-Helper

계피(Cinnamomum cassia Presl)의 열수 추출물은 alcohol dehydrogenase (ADH)의 활성을 저해하였고 IC50값은 45.6 ㎍/mL이었다. 계피 추출물의 ADH 저해 성분은 산과 열에 비교적 안정하였으나 휘발성을 가진 물질로 나타났다. 계피에서 ADH 저해 물질의 추출을 위한 최적 온도와 시간은 각각 80 ℃와 2시간이었다. 계피의 정유 성분 중 cinnamaldehyde가 ADH 저해의 주된 물질이었다. Cinnamaldehyde는 기질인 에탄올에 대해 ADH 활성의 경쟁적 저해제로 여겨진다. 따라서 계피 열수 추출물과 cinnamaldehyde는 ADH의 활성을 효과적으로 저해하는 숙취해소 천연소재로서의 활용가능성을 보여주었다.

Abstract AI-Helper 아이콘AI-Helper

The hot water extract from cinnamon (Cinnamomum cassia Presl) inhibited the activity of alcohol dehydrogenase (ADH) with IC50 value of 45.6 ㎍/mL. The ADH inhibitory components in cinnamon extract were relatively stable to acid and heat, but were found to be volatile. The optimum temperature a...

주제어

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