[논문]화학물질 우선순위 선정기법(CRS)을 활용한 허가대상 후보물질 선정 연구

김효동; 박교식

doi:10.15269/jksoeh.2022.32.3.253

화학물질 우선순위 선정기법(CRS)을 활용한 허가대상 후보물질 선정 연구
A Study on the Selection of Candidates for Substances Subject to Permission Using Chemicals Ranking and Scoring (CRS) 원문보기

한국산업보건학회지 = Journal of Korean Society of Occupational and Environmental Hygiene, v.32 no.3, 2022년, pp.253 - 267

김효동 (숭실대학교 안전.보건융합공학과) , 박교식 (숭실대학교 안전.보건융합공학과)

Abstract ▼ AI-Helper

Objectives: This study was performed to check whether the CRS (Chemical Ranking and Scoring) system is appropriate as a method to determine substances as candidates for substances subject to permission and to apply this system to the selection of candidates for substances subject to permission. Methods: A risk score was obtained by multiplying the hazard score and the exposure score and then ranking them. The hazard sub-indicators are carcinogenicity, germ cell mutagenicity, reproductive toxicity, specific target organ toxicity-repeated exposure, respiratory sensitization and endocrine disrupting chemicals. Exposure sub-indicators are persistence, bioaccumulation and emission volume. Sensitivity analysis was performed for missing values. Correlation analysis and multivariable linear regression analysis were performed among hazard, exposure and risk in order to confirm that CRS was an appropriate method. Results: As a result of the sensitivity analysis on missing values, it was confirmed that the effect on the risk ranking was not sensitive. Correlation and regression analysis confirmed that exposure had a greater effect on risk than hazard. Conclusions: The CRS system, which derives a risk score using a hazard and exposure score, is judged to be appropriate as a method for the selection of preliminary of candidates for substances subject to permission. Benzene, cadmium, nickel, and cobalt were selected as priority candidates for substances subject to permission.

주제어

표/그림 (11)

그림 Figure 1. Scheme of risk scoring Abbreviations; C: carcinogenicity, M: germ cell mutagenicity, R: reproductive toxicity, RE: specific target organ toxicityrepeated exposure, RS: respiratory sensitization, E: endocrine disrupting chemicals, P: persistent, B: bioaccumulative, V: emission volume
표 Table 1. Scoring of bioaccumulation, persistence and emission volumes
그림 Figure 2. Percentage (%) of sub-indicators score Abbreviations; C: carcinogenicity, M: germ cell mutagenicity, R: reproductive toxicity, RE: specific target organ toxicity-repeated exposure, RS: respiratory sensitization, E: endocrine disrupting chemicals, P: persistent, B: bioaccumulative, V: emission volume
표 Table 2. Correlation coefficients (r) for hazard (up) and exposure (down) of sub-indicators
표 Table 3. Top 12 ranked by hazard scores and their risk ranks
표 Table 4. Correlation coefficients (r) for hazard, exposure, and risk and their sub-indicators
그림 Figure 3. Scatter plot of correlation: between hazard with exposure, between hazard with risk and between exposure with risk
표 Table 5. Multivariable linear regression analysis of indicators and sub-indicators
표 Table 6. Regulatory lists and ranks of preliminary of candidates for substance subject to permission
표 Table 6. Continued
표 Table 7. Regulatory lists of substances excluded from candidates for substance subject to permission

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