[논문]Anti-inflammatory, Anti-oxidative and Anti-bacterial Activities of the Constituents Extracted from Leaves of Talipariti hamabo

Xu Hui Liang; Jung Eun Kim; Nam Ho Lee

doi:10.5012/jkcs.2023.67.2.145

[국내논문] Anti-inflammatory, Anti-oxidative and Anti-bacterial Activities of the Constituents Extracted from Leaves of Talipariti hamabo 원문보기

대한화학회지 = Journal of the Korean Chemical Society, v.67 no.2, 2023년, pp.145 - 149

Xu Hui Liang (Department of Chemistry and Cosmetics, Jeju National University) , Jung Eun Kim (Department of Chemistry and Cosmetics, Jeju National University) , Nam Ho Lee (Department of Chemistry and Cosmetics, Jeju National University)

Abstract ▼ AI-Helper

Talipariti hamabo is a plant growing around salt marshes in the Lava Coast region of Jeju Island, Korea. In this study, the extract of T. hamabo leaves was investigated for the anti-inflammatory, anti-oxidative and anti-bacterial activities and their active constituents were identified. In the anti-inflammatory tests using lipopolysaccharide-stimulated RAW264.7 cells, the ethyl acetate (EtOAc) fraction inhibited the nitric oxide production without causing cell toxicity. Moreover, the EtOAc fraction reduced pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-6) as well as prostaglandin E2. In the anti-oxidative studies with DPPH and ABTS+ radicals, potent scavenging activities were observed in the EtOAc and n-butanol fractions. Upon the anti-bacterial tests using Staphylococcus epidermidis, EtOAc and n-butanol fractions exhibited good activities. Through the phytochemical studies on EtOAc fraction, three components were isolated by repeated column chromatography; oleic acid (1), p-hydroxyphenethyl-trans-ferulate (2), nicotiflorine (3). Based on these results, the extract of T. hamabo leaves can be developed as natural resources for cosmetic applications.

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표/그림 (6)

$Figure 1. Effects of extract and solvent fractions from T. hamabo leaves on NO production (A) and cell viability (B) in LPS-induced RAW264.7 cells. The data represent the mean±SD of triplicate experiments. *p < 0.05; **p < 0.01.$ 그림 Figure 1. Effects of extract and solvent fractions from T. hamabo leaves on NO production (A) and cell viability (B) in LPS-induced RAW264.7 cells. The data represent the mean±SD of triplicate experiments. *p < 0.05; **p < 0.01.
$Figure 2. Effects of EtOAc fraction from T. hamabo leaves on NO production (A) and cell viability (B) in LPS-induced RAW264.7 cells. The data represent the mean±SD of triplicate experiments. *p < 0.05; **p < 0.01.$ 그림 Figure 2. Effects of EtOAc fraction from T. hamabo leaves on NO production (A) and cell viability (B) in LPS-induced RAW264.7 cells. The data represent the mean±SD of triplicate experiments. *p < 0.05; **p < 0.01.
$Figure 3. Effects of EtOAc fraction from T. hamabo leaves on production of TNF-α (A), IL-6 (B) and PGE<sub>2</sub> (C) and cell viability in LPS-indued RAW264.7 cells. The data represent the mean ±SD of triplicate experiments. *p < 0.05; **p < 0.01.$ 그림 Figure 3. Effects of EtOAc fraction from T. hamabo leaves on production of TNF-α (A), IL-6 (B) and PGE₂ (C) and cell viability in LPS-indued RAW264.7 cells. The data represent the mean ±SD of triplicate experiments. *p < 0.05; **p < 0.01.
표 Table 1. SC₅₀ Values of Extract and Solvent Fractions from T. hamabo Leaves on DPPH and ABTS+ Radical Scavenging
표 Table 2. Anti-bacterial Activities of T. hamabo Leaves
그림 Figure 4. Isolated compounds 1-3 from T. hamabo leaves.

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