[논문]아토피 피부염에서 한약 외용제와 양약 병용 치료의 효과: 체계적 문헌고찰 및 메타분석

이지은; 박수진; 전서연; 김규석

아토피 피부염에서 한약 외용제와 양약 병용 치료의 효과: 체계적 문헌고찰 및 메타분석
Efficacy of Combination Treatment of Herbal Medicine for External Use and Western Medicine for Atopic Dermatitis: A Systematic Review and Meta Analysis 원문보기

대한융합한의학회지 = Journal of Convergence Korean Medicine, v.5 no.1, 2023년, pp.5 - 23

이지은 (경희대학교 한의과대학 안이비인후피부과 교실) , 박수진 (경희대학교 한의과대학 안이비인후피부과 교실) , 전서연 (경희대학교 한의과대학 안이비인후피부과 교실) , 김규석 (경희대학교 한의과대학 안이비인후피부과 교실)

Abstract ▼ AI-Helper

Objectives: This study was conducted to evaluate the effect of combination treatment of herbal medicine for external use and western medicine for atopic dermatitis (AD). Methods: We searched randomized controlled trials (RCTs) which assess the effect of combination treatment of herbal and western medicine for AD through 8 electronic databases from the start to December 2022. The data synthesis was conducted by using Review Manager (RevMan, ver.5.4.1) and Cochrane risk-of-bias tool was used to evaluate the risk of bias. Results: 13 RCTs were included. The combination treatment group had significantly higher total efficacy rate(p<0.0001) and lower SCORAD score (p<0.00001) than the western medicine treatment group. The adverse event rate was also significantly lower in the combination treatment than the western medicine treatment group (p<0.0001). But there was no significant difference in recurrence rate (p=0.09). Conclusion: This study demonstrates that the combination treatment of herbal and western medicine could be safe and effective for AD. However, due to limits of included studies such as high heterogeneity between the literature and unclear risk of bias, further studies are warranted.

주제어

표/그림 (9)

그림 Fig. 1. Flow Chart of the Study
그림 Fig. 2. Forest Plot : Total Efficacy Rate
그림 Fig. 3. Forest Plot : SCORAD Score
그림 Fig. 4. Forest Plot : Adverse Events Rate
그림 Fig. 5. Forest Plot : Recurrence Rate
그림 Fig. 6. Risk of Bias Summary
그림 Fig. 7. Risk of Bias Graph
표 Table 1. Summary of Included Studies
표 Table 2. Configuration of Herbal Medicine

참고문헌 (46)

Jang HS. Diagnosis and Treatment of？Atopic Dermatitis. Korean Journal of？Family Medicine. 2002;23(7);2-840.
Korean Dermatological Association.？Textbook of Dermatology, 7th rev.？McGraw Hill. 2020;158
Williams H, Robertson C, Stewart A,？Ait-Khaled N, Anabwani G, Anderson R,？Asher I, Beasley R, Bjorksten B, Burr M,？Clayton T, Crane J, Ellwood P, Keil U, Lai？C, Mallol J, Martinez F, Mitchell E,？Montefort S, Pearce N, Weiland SK.？Worldwide variations in the prevalence of？symptoms of atopic eczema in the？International Study of Asthma and？Allergies in Childhood. The Journal of？allergy and clinical immunology. 1999;103(1？Pt 1);125-138.
Mortz CG, Andersen, KE, Dellgren C,？Barington T, Bindslev-Jensen C. Atopic？dermatitis from adolescence to adulthood？in the TOACS cohort: prevalence,？persistence and comorbidities. Allergy.？2015;70(7);836-845

상세보기
Deckers IA, McLean S, Linssen S,？Mommers M, van Schayck CP, Sheikh A.？Investigating international time trends in？the incidence and prevalence of atopic？eczema 1990-2010: a systematic review of？epidemiological studies. PLOS ONE.？2012;7(7);ARTN e39803.

상세보기
Kim HS. Treatment for atopic dermatitis.？Journal of the Korean Medical Association.？2014;57(3);226-233.
Kim YH, Lee HC. The Oriental and？Western Medical Study. The Journal of？Pediatrics of Korean Medicine.？1993;7(1);121-133
Shin SH, Kim MB, Byun SM, Lee HS, Park？SG, Ko WS, Yoon HJ. A Review on？External Treatment for Atopic Dermatitis？in Korean Journals. The journal of Korean？Medicine Ophthalmology & Otolaryngology？& Dermatology. 2008;21(2);80-93.
Wu Q, Ruan H, Zhao W, Mo X, Wen X,？Chen D. External therapies of traditional？Chinese medicine for atopic dermatitis: A？Meta-Analysis. China Journal of Traditional？Chinese Medicine and Pharmacy.？2015;30(12);4462-4465.
Ying Z, Hiroko K, Sei K. Add-on therapy？with traditional Chinese medicine: An？efficacious approach for lipid metabolism？disorders. Pharmacological Research.？2018;134:200-11.
Kim NJ. Interaction of Co-administration？with Traditional Herbal Drugs and？Western Drugs. J. Kor. Soc. Hosp. Pharm.？1998;15(2):247-57.
Han CY, Kim JD, Kang DW, Kim KS, Kim？YB. Review about using Herbal medicine？on steroid tapering and steroid overuse in？Skin disease. The journal of Korean？Medicine Ophthalmology & Otolaryngology & Dermatology. 2020;33(3);115-124.
Lee HS. An overview of herbal medicine？for atopic dermatitis. (The Korean？Medicine Society for the Herbal Formula？Study). 2009;17(2);99-110.
Choi IH, Kim SH. Kim YC, Yoon YH. A？Clinical Study of Shi Ho Cheong Gan-San？on Blood Heat Pattern Atopic Dermatitis:？a randomized, double-blind clinical trial.？2011;24(1);96-110.
Lee MH, Choi YH, Han MH, Yoon JJ,？Song MK, Kim MJ, Hong SH, Choi BT,？Kim BW, Hwang HJ. Medicinal Herb？Extracts Attenuate？1-Chl or o -2,4 dini t r obenzen e-in duce d？Development of Atopic Dermatitis-like？Skin Lesions. 2014;24(8);851-859.
O MJ, Yoo YB., Lim SH, Kim HT. A？clinical study for the effect of ointment？contained Takrisodok-Eum on recovering？the damaged skin barrier by Atopic？dermatitis. The Journal of Korean？Medicine Ophthalmology and？Otolaryngology and Dermatology.？2011;24(3);84-107.
Hong JH, Jung HA. Clinical Efficacy of？External Application Containing Betula？platyphyllae Cortex, Viticis Fructus,？Agrimoniae herba in Atopic Dermatitis.？The Journal of Korean Medicine？Ophthalmology and Otolaryngology and？Dermatology. 2014;27(1);1-16.
Kang MS, Kim JB, Kim HT. A Clinical？Study for the Effect of External？Applications Containing Herbal Extracts？on Mild Atopic Dermatitis Patients.？2014;27(3);40-55.
Min DL, Park EJ, Kang KH. Review of？Clinical and Experimental Studies on？External Application Treatment for Atopic？Dermatitis in the Korean Literature. The？Journal of Pediatrics of Korean Medicine.？2013;27(1);36-49.
Wu Q, Ruan H, Zhao W, Mo X, Wen X,？Chen D. External therapies of traditional？Chinese medicine for atopic dermatitis: A？Meta-Analysis. China Journal of？Traditional Chinese Medicine and？Pharmacy. 2015;30(12);4462-4465.
Huang W. Efficacy of Chinese herbal？bath combined with tacrolimus ointment？in the treatment of atopic dermatitis in？children. Journal of Practical Traditional？Chinese Medicine. 2021;37(10);1688-1689.
Xi M. Clinical Study on Emollient and？Anti-Pruritus Thought in Chinese？Medicine for Atopic Dermatitis. Journal of？New Chinese Medicine.？2021;53(09);178-181.
Xu S, Ding Y, Yi X, Huang Q. Efficacy？of Chinese herbal medicine Huanglian？paste wet pack combined with？glucocorticoid ointment topical treatment？of moderate and severe atopic dermatitis？in adults. Chinese Journal of？Dermatovenereology of Integrated？Traditional and Western Medicine.？2020;19(06);575-576.
Li P, Li B, Liu H. Clinical Observation of？Ebastine Combined with Portulacae Herba？in the Treatment of Atopic Dermatitis.？Chinese Journal of Modern Applied？Pharmacy. 2020;37(06);736-740.
Xu J, Chen S. Clinical observation on the？treatment of pediatric atopic dermatitis？with damp-heat encapsulation by？combining traditional Chinese and？Western medicine with external？treatment. Journal of North Pharmacy.？2017;14(08);9-10.
Chen J, He X. Therapeutic Effect of Jin？Yu Waixi Recipe for Pediatric Atopic？Dermatitis Children with Different？Traditional Chinese Medical Constitutions.？Journal of Guangzhou University of？Traditional Chinese Medicine. 2017;34(01);？35-39.
Huang W, Wang C. Curative effect of？TCM medicated bath combined with？tacrolimus on moderate to severe atopic？dermatitis in children and influence on？serum LTB4 on LTC4. Chinese Journal of？General Practice. 2016;14(04);604-606,？685.
Han H, Guo F, Liu H. A randomized？single-blind clinical trial on the efficacy？and safety of using herbal baths in？combination with tacrolimus ointment in？the treatment of atopic dermatitis in？children, Guide of China Medicine.？2013;11(06);606-608.
Li P, Wu L, Zhou F, Zhang S. Clinical？Observation on Dafengzi Ointment？Combined with Chinese Medication？Decoction for 30 Cases of Atopic？Dermatitis. Journal of Traditional Chinese？Medicine. 2012;53(08);678-680.
Wu D. Liang Y. Li Y. A Comparative？Study of adjuvant treatment for atopic？Dermatitis in infants with natural indigo.？Public Medical Forum Magazine.？2007;19;869-870.
Yu Q. Effect Observation and Quality of？Life Analysis of Traditional Chinese？Medicine Bath on Atopic Dermatitis.？Xinjiang Medical University. 2019.
Xue X. Therapeutic effect of traditional？Chinese medicine bath combined with？tacrolimus on atopic dermatitis and serum？inflammatory mediators. 2018;6(2).
Wu Q, Jing H, Zhang F, Wang W, Wang？X. Clinical effect of JIANG Shujing？Zhitong Xiaoyan ointment on atopic？dermatitis. 2020;5(22);117-119.
Korean Dermatological Association.？Textbook of Dermatology, 7th rev.？McGraw Hill. 2020;163-164.
Saraswat A. Topical corticosteroid use in？children: adverse effects and how to？minimize them. Indian journal of？dermatology, venereology and leprology.？2010;76(3);225-8.
Annie C. Nicholas VN. The Use of？Topical Calcineurin Inhibitors in Atopic？Dermatitis. The Open Dermatology？Journal. 2014;8;12-17.

상세보기
The Society of Korean Medicine？Ophthalmology, Otolaryngology &？Dermatology. Text of Traditional Korean？Dermatology & Surgery. GB. 2022;24
Shin SH, Kim MB, Byun SM, Lee HS,？Park SG, Ko WS, Yoon HJ. A Review on？External Treatment for Atopic Dermatitis？in Korean Journals. The journal of？Korean Medicine Ophthalmology &？Otolaryngology & Dermatology.？2008;21(2);80-93.
Guo Z, Li Y, Hou Y, Wang Y, Liang Y,？Si X, Pan G, Wang Y, Hu Q. Chinese？herbal bath therapy for the treatment of？Atopic dermatitis in children: A？meta-analysis and systematic review.？2022;101(47);e31923.
Yoon JM, Kim DB, Park YC. Effect of？Taeyeol-go on Atopic Dermatitis.？2006;15(2);187-192.
Ahn JH, Yun YH, Kim MH, Ko SG, Kim？KS, Choi IH. Efficacy and safety of？topical Jaungo application in patients with？atopic dermatitis : a randomized, double-blind, placebo-controlled study.？Complementary therapies in medicine.？2018;40;22-28.
Kim AN, Kim SK, Seo JS, Kim SH, Kim？YE, Jang HC. Analysis on the herbal？combinations in Korean medicine for？atopic dermatitis. The Journal of Korean？Medicine Ophthalmology and？Otolaryngology and Dermatology.？2016;29(2);82-97.
Andoh T, Yoshihisa Y, Rehman M,？Tabuchi Y, Shimizu T. Berberine induces？anti-atopic dermatitis effects through the？downregulation of cutaneous EIF3F and？MALT1 in NC/Nga mice with atopy-like？dermatitis. Biochemical pharmacology,？2021;185;114439

상세보기
Joo JK, Han HS, Lee YJ.？Anti-inflammatory Effect of Portulacae？Herba Water Extract on？Lipopolysaccharide-activated RAW 264.7？Macrophages. The Korea Journal of？Herbology. 2016;31(1);61-67.
Lim YY, Kim HM, Park WS, Kim JH, Shin？HJ, Kim MN, Kim BJ. Anti-inflammatory？and Anti-pruritic Effects of Portulaca？oleracea L. Extract Using In Vitro and In？Vivo Inflammation Model: LPS-treated？Raw264.7 Cells, Keratinocytes, NC/Nga？Mice and Hairless SKH-1 Mice. Allergy,？Asthma & Immunology Research.？2011;31(3);199-206.
Wei-Jie L, Huang J, Li S, Gong X, Sun J,？Mao W, Guo S. Portulaca oleracea L.？extracts alleviate？2,4-dinitrochlorobenzene-induced atopic？dermatitis in mice. Frontiers in nutrition,？2022;9;986943.？

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