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[국내논문] 미세먼지에 의한 노화 및 노화 관련 질병에 대한 최근 연구 동향
Recent Understanding in Particular Matter-Mediated Aging and Age-Related Diseases

생명과학회지 = Journal of life science, v.34 no.1, 2024년, pp.68 - 77  

방은진 (동의대학교 항노화연구소) ,  최영현 (동의대학교 항노화연구소)

초록
AI-Helper 아이콘AI-Helper

다양한 원인에 의하여 발생하는 미세먼지(particulate matter, PM)는 강력한 환경 오염 물질로 대두되고 있다. PM은 서로 다른 구성과 크기의 고체 입자와 액체 방울로 구성되며, 유해 화학 성분에는 원소 및 유기 탄소, 유기 화합물, 생물학적 화합물 및 금속이 포함된다. 급성 및 만성 PM 노출 시 생체 내 생리학적 시스템에 의하여 유입되고 축적되어 세포내 소포체 스트레스, 미토콘드리아 기능 장애, 산화 스트레스, 염증, 지질 축적 및 세포 주기 정지와 함께 세포 구조 변화를 촉진한다. 궁극적으로 이러한 세포 반응은 노화의 주요 특성을 발달시키는 원인으로 작용하며, 세포 노화와 관련된 자가포식 플럭스리소좀 기능 장애를 향상시킨다. 선행 연구에서 PM과 사망률 증가 또는 수명 감소 사이의 긍정적인 연관성을 강조했지만, 노화에 대한 PM의 직접적인 증거는 여전히 제한적이다. 이 총설에서는 관찰 연구뿐만 아니라 노화 진행 및 연령 관련 질병 발병에 대한 PM의 시험관 내 및 생체 내 증거를 평가하였다. 이러한 평가는 소포체 스트레스, 미토콘드리아 기능 장애, 산화 스트레스, 염증, 지방 축적, 자가포식을 포함하여 PM 노출과 노화 사이의 연관성을 강화하는 연령 관련 세포 변화를 기반으로 한다. 이러한 자료는 PM에 따른 기본적인 세포 반응의 이해를 토대로 PM으로 인한 노화에 대한 새로운 치료법 개발에 기여할 수 있을 것이다.

Abstract AI-Helper 아이콘AI-Helper

Airborne particulate matter (PM) is an environmentally hazardous pollutant that originates from various sources. PM is comprised of solid particles and liquid droplets of diverse composition and size. Hazardous chemical compositions of PM include elemental and organic carbon, organic compounds, biol...

주제어

표/그림 (2)

AI 본문요약
AI-Helper 아이콘 AI-Helper

성능/효과

  • 하지만, 서로 다른 국가 및 지역에서 수행된 다양한 유형의 연구에서 미세먼지와 노화 및 노화 관련 질병 사이의 밀접한 연관성이 있다는 결론을 내릴 수 있다. 종합적으로, 이러한 연구결과들은 미세먼지의 노출과 노화 그리고 비만, 지방간, 만성신장질환, 근위축 및 골다공증와 같은 노화관련 병리학적 상태와의 인과 관계를 강력하게 시사한다.
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