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NTIS 바로가기Bulletin of the Korean chemical society, v.41 no.4, 2020년, pp.444 - 449
Lee, Ju Mi (Department of Chemistry and Institute of Applied Chemistry Hallym University Chuncheon 24252 Republic of Korea) , Damodar, Kongara (Department of Chemistry and Institute of Applied Chemistry Hallym University Chuncheon 24252 Republic of Korea) , Lee, Yeontaek (Department of Life Science and Multidisciplinary Genome Institute Hallym University Chuncheon 24252 Republic of Korea) , Woo, Hyeong Ryeol (Department of Chemistry and Institute of Applied Chemistry Hallym University Chuncheon 24252 Republic of Korea) , Suh, Hong Won (Department of Pharmacology and Institute of Natural Medicine College of Medicine, Hallym University Chuncheon 24252 Republic of Korea) , Jeon, Sung Ho (Department of Life Science and Multidisciplinary Genome Institute Hallym University Chuncheon 24252 Republic of Korea) , Lee, Jeong Tae (Department of Chemistry and Institute of Applied Chemistry Hallym University Chuncheon 24252 Republic of Korea)
A set of novel epinastine (1) and mefenamic acid (2) hybrids (3-7) tethered via amide bond were designed and synthesized with the artistry of molecular hybridization. Then their inhibitory effect on nitric oxide (NO) production in LPS‐induced RAW‐264.7 macrophages and the expression le...
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Hybrid Molecules with a Dual Mode of Action: Dream or Reality?
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Bargh, Jonathan D., Isidro-Llobet, Albert, Parker, Jeremy S., Spring, David R.. Cleavable linkers in antibody-drug conjugates. Chemical Society reviews, vol.48, no.16, 4361-4374.
Lee, Ju Mi, Damodar, Kongara, Lee, Yeontaek, Lee, Jae‐Yong, Jeon, Sung Ho, Lee, Jeong Tae. Synthesis and Biological Assay of Hybrids Between Epinastine and Salicylic Acid as Promising Nitric Oxide Production Inhibitors. Bulletin of the Korean chemical society, vol.40, no.8, 761-766.
Mazzio, E.A., Bauer, D., Mendonca, P., Taka, E., Soliman, K.F.A.. Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells. Journal of neuroimmunology, vol.302, 10-19.
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Font-Nieves, Miriam, Sans-Fons, M. Glòria, Gorina, Roser, Bonfill-Teixidor, Ester, Salas-Pérdomo, Angélica, Márquez-Kisinousky, Leonardo, Santalucia, Tomàs, Planas, Anna M.. Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2 Production in Astrocytes. The Journal of biological chemistry, vol.287, no.9, 6454-6468.
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