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Novel Hybrid Molecules of Epinastine and Mefenamic Acid for Bioactive Assessment as Potential Anti‐inflammatory Agents 원문보기

Bulletin of the Korean chemical society, v.41 no.4, 2020년, pp.444 - 449  

Lee, Ju Mi (Department of Chemistry and Institute of Applied Chemistry Hallym University Chuncheon 24252 Republic of Korea) ,  Damodar, Kongara (Department of Chemistry and Institute of Applied Chemistry Hallym University Chuncheon 24252 Republic of Korea) ,  Lee, Yeontaek (Department of Life Science and Multidisciplinary Genome Institute Hallym University Chuncheon 24252 Republic of Korea) ,  Woo, Hyeong Ryeol (Department of Chemistry and Institute of Applied Chemistry Hallym University Chuncheon 24252 Republic of Korea) ,  Suh, Hong Won (Department of Pharmacology and Institute of Natural Medicine College of Medicine, Hallym University Chuncheon 24252 Republic of Korea) ,  Jeon, Sung Ho (Department of Life Science and Multidisciplinary Genome Institute Hallym University Chuncheon 24252 Republic of Korea) ,  Lee, Jeong Tae (Department of Chemistry and Institute of Applied Chemistry Hallym University Chuncheon 24252 Republic of Korea)

Abstract AI-Helper 아이콘AI-Helper

A set of novel epinastine (1) and mefenamic acid (2) hybrids (3-7) tethered via amide bond were designed and synthesized with the artistry of molecular hybridization. Then their inhibitory effect on nitric oxide (NO) production in LPS‐induced RAW‐264.7 macrophages and the expression le...

참고문헌 (19)

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  5. Mizoguchi, Takanori, Ozaki, Mineo, Ogino, Nobuchika. Efficacy of 0.05% epinastine and 0.1% olopatadine for allergic conjunctivitis as seasonal and preseasonal treatment. Clinical ophthalmology, vol.11, 1747-1753.

  6. Pradhan, Shilpi, Abhishek, Kumar, Mah, Francis. Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects. Expert opinion on drug metabolism & toxicology, vol.5, no.9, 1135-1140.

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  8. Ghanghas, Preety, Jain, Shelly, Rana, Chandan, Sanyal, S.N.. Chemopreventive action of non-steroidal anti-inflammatory drugs on the inflammatory pathways in colon cancer. Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie, vol.78, 239-247.

  9. Meunier, Bernard.. Hybrid Molecules with a Dual Mode of Action: Dream or Reality?. Accounts of chemical research, vol.41, no.1, 69-77.

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  11. Design of Hybrid Molecules for Drug Development Decker M. 2017 

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  13. 10.1002/9780470921920.edm020 

  14. Bargh, Jonathan D., Isidro-Llobet, Albert, Parker, Jeremy S., Spring, David R.. Cleavable linkers in antibody-drug conjugates. Chemical Society reviews, vol.48, no.16, 4361-4374.

  15. Lee, Ju Mi, Damodar, Kongara, Lee, Yeontaek, Lee, Jae‐Yong, Jeon, Sung Ho, Lee, Jeong Tae. Synthesis and Biological Assay of Hybrids Between Epinastine and Salicylic Acid as Promising Nitric Oxide Production Inhibitors. Bulletin of the Korean chemical society, vol.40, no.8, 761-766.

  16. Mazzio, E.A., Bauer, D., Mendonca, P., Taka, E., Soliman, K.F.A.. Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells. Journal of neuroimmunology, vol.302, 10-19.

  17. Leyva-López, Nayely, Gutierrez-Grijalva, Erick P., Ambriz-Perez, Dulce L., Heredia, J. Basilio. Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases. International journal of molecular sciences, vol.17, no.6, 921-.

  18. Caivano, Matilde, Gorgoni, Barbara, Cohen, Philip, Poli, Valeria. The Induction of Cyclooxygenase-2 mRNA in Macrophages Is Biphasic and Requires both CCAAT Enhancer-binding protein β (C/EBPβ) and C/EBPδ Transcription Factors. The Journal of biological chemistry, vol.276, no.52, 48693-48701.

  19. Font-Nieves, Miriam, Sans-Fons, M. Glòria, Gorina, Roser, Bonfill-Teixidor, Ester, Salas-Pérdomo, Angélica, Márquez-Kisinousky, Leonardo, Santalucia, Tomàs, Planas, Anna M.. Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2 Production in Astrocytes. The Journal of biological chemistry, vol.287, no.9, 6454-6468.

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