$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19 원문보기

European journal of pharmacology, v.890, 2021년, pp.173720 -   

Toor, Himanshu G. (P.G. Department of Genetics, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences (ARIBAS), Charutar Vidya Mandal University) ,  Banerjee, Devjani I. (Dr. Vikram Sarabhai Institute of Cell and Molecular Biology, Faculty of Science, The Maharaja Sayajirao University of Baroda) ,  Lipsa Rath, Soumya (National Institute of Technology) ,  Darji, Siddhi A. (Dr. Vikram Sarabhai Institute of Cell and Molecular Biology, Faculty of Science, The Maharaja Sayajirao University of Baroda)

Abstract AI-Helper 아이콘AI-Helper

Abstract COVID-19 has intensified into a global pandemic with over a million deaths worldwide. Experimental research analyses have been implemented and executed with the sole rationale to counteract SARS-CoV-2, which has initiated potent therapeutic strategy development in coherence with computatio...

주제어

참고문헌 (94)

  1. Al-Khayyat M.Z.S. Al-Dabbagh A.G.A. In silico prediction and docking of tertiary structure of LuxI, an inducer synthase of Vibrio fischeri Rep. Biochem. Mol. Biol. 4 2 2016 66 75 27536699 

  2. A Chronicle on the SARS Epidemic Chin. Law Govern. 36 4 2003 12 15 10.2753/CLG0009-4609360412 

  3. Alanagreh L. Alzoughool F. Atoum M. The human coronavirus disease COVID-19: its origin, characteristics, and insights into potential drugs and its mechanisms Pathogens 9 331 2020 1 11 10.3390/pathogens9050331 

  4. Andersen K.G. Rambaut A. Lipkin W.I. Holmes E.C. Garry R.F. The proximal origin of SARS-CoV-2 Nat. Med. 26 2020 450 455 10.1038/s41591-020-0820-9 32284615 

  5. Anthis N.J. Clore G.M. Sequence-specific determination of protein and peptide concentrations by absorbance at 205 nm Proteome Sci. 22 2013 851 858 10.1002/pro.2253 

  6. Apweiler R. Bairoch A. Wu C.H. Barker W.C. Boeckmann B. Ferro S. Gasteiger E. Huang H. Lopez R. Magrane M. Martin M.J. Natale D.A. O'Donovan C. Redaschi N. Yeh L.L. UniProt: the universal protein knowledgebase Nucleic Acids Res. 32 2004 115 119 10.1093/nar/gkh131 14704348 

  7. Armenteros J.J.A. Sonderby C.K. Sonderby S.K. Nielsen H. Winther O. DeepLoc: prediction of protein subcellular localization using deep learning Bioinformatics 33 21 2017 3387 3395 10.1093/bioinformatics/btx431 29036616 

  8. Ayati A. Falahati M. Irannejad H. Emami S. Synthesis, in vitro antifungal evaluation and in silico study of 3-azolyl-4-chromanone phenylhydrazones DARU J. Pharm. Sci. 20 46 2012 1 7 10.1186/2008-2231-20-46 

  9. Bayan L. Koulivand P.H. Gorji A. Garlic: a review of potential therapeutic effects Avicenna J. Phytomed. 4 1 2014 1 14 25050296 

  10. Berman H.M. Westbrook J. Feng Z. Gilliland G. Bhat T.N. Weissig H. Shindyalov I.N. Bourne P.E. The protein Data Bank Nucleic Acids Res. 28 1 2000 235 242 10592235 

  11. Blom N. Gammeltoft S. Brunak S. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites J. Mol. Biol. 294 5 1999 1351 1362 10.1006/jmbi.1999.3310 10600390 

  12. Boesecke C. Gelgor L. A review of Raltegravir and its use in HIV-1 infection Clin. Med. Therapeut. 1 2009 1159 1171 10.4137/CMT.S1985 

  13. Caly L. Druce J.D. Catton M.G. Jans D.A. Wagstaff K.M. The FDA-approved drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro Antivir. Res. 178 2020 1 4 10.1016/j.antiviral.2020.104787 

  14. Ciliberto G. Boosting the arsenal against COVID-19 through computational drug repurposing Drug Discov. Today 1?3 2020 10.1016/j.drudis.2020.04.005 

  15. Coutard B. Valle C. de Lamballerie X. Canard B. Seidah N.G. Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade Antivir. Res. 176 2020 1 5 10.1016/j.antiviral.2020.104742 

  16. Daina A. Zoete V. A BOILED-egg to predict gastrointestinal absorption and brain penetration of small molecules ChemMedChem 11 2016 1117 1121 10.1002/cmdc.201600182 27218427 

  17. Daina A. Michielin O. Zoete V. iLOGP: a simple, robust, and efficient description of n-octanol/water partition coefficient for drug design using the GB/SA approach J. Chem. Inf. Model. 54 12 2014 3284 3301 10.1021/ci500467k 25382374 

  18. Daina A. Michielin O. Zoete V. SwissADME: a free web tool to evaluate pharmacokinetics, druglikeness and medicinal chemistry friendliness of small molecules Sci. Rep. 7 2017 1 13 10.1038/srep42717 28127051 

  19. Dassault Systemes Biovia Discovery Studio, v20.1.0.19295 2017 Dassault Systemes San Diego 

  20. Delaney IV W.E. Ray A.S. Yang H. Qi X. Xiong S. Zhu Y. Miller M.D. Intracellular metabolism and in vitro activity of Tenofovir against Hepatitis B virus Antimicrob. Agents Chemother. 50 7 2006 2471 2477 10.1128/AAC.00138-06 16801428 

  21. Devaux C.A. Rolain J.M. Colson P. Raoult D. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? Int. J. Antimicrob. Agents 55 2020 1 6 10.1016/j.ijantimicag.2020.105938 

  22. Di Gennaro F. Pizzol D. Marotta C. Antunes M. Racalbuto V. Veronese N. Smith L. Coronavirus Diseases (COVID-19) current status and future perspectives: a narrative review Int. J. Environ. Res. Publ. Health 17 2690 2020 1 11 10.3390/ijerph17082690 

  23. Drozdetskiy A. Cole C. Proctor J. Barton G.J. JPred4: a protein secondary structure prediction server Nucleic Acids Res. 43 2015 389 394 10.1093/nar/gkv332 

  24. Du Y. Chen X. Favipiravir: pharmacokinetics and concerns about clinical trials for 2019-nCoV Infection Clin. Pharmacol. Therapeut. 108 2 2020 1 6 10.1002/cpt.1844 

  25. Duan Y. Zhu H. Zhou C. Advance of promising targets and agents against COVID-19 in China Drug Discov. Today 25 5 2020 810 812 10.1016/j.drudis.2020.02.011 32198066 

  26. Ferre F. Clote P. DiANNA: a web server for disulfide connectivity Prediction Nucleic Acids Res. 33 2005 230 232 10.1093/nar/gki412 

  27. Fiser A. Do R.K.G. Sali A. Modeling of loops in protein structures Proteome Sci. 9 9 2000 1753 1773 10.1110/ps.9.9.1753 

  28. Gasteiger E. Hoogland C. Gattiker A. Duvaud S. Wilkins M.R. Appel R.D. Bairoch A. Protein identification and analysis tools on the ExPASy server Walker J.M. The Proteomics Protocols Handbook 2005 Humana Press Inc. Totowa, New Jersey 571 607 

  29. Gupta R. Brunak S. Prediction of glycosylation across the human proteome and the correlation to protein function Pac. Symp. Biocomput. 7 2002 310 322 

  30. Hafeez A. Saify Z.S. Naz A. Yasmin F. Akhtar N. Molecular docking study on the interaction of riboflavin (vitamin B2) and cyanocobalamin (vitamin B12) coenzymes J. Comput. Med. 1?5 2013 10.1155/2013/312183 

  31. Hafeez A. Ahmad S. Siddiqui S.A. Ahmad M. Mishra S. A review of COVID-19 (coronavirus disease-2019) diagnosis, treatments and prevention EJMO 4 2 2020 116 125 10.14744/ejmo.2020.90853 

  32. Holmes N.E. Charles P.G.P. Safety and efficacy review of Doxycycline Clin. Med. Therapeut. 1 2009 471 482 10.4137/CMT.S2035 

  33. Hsu K. Chen Y. Lin S. Yang J. iGEMDOCK: a graphical environment of enhancing GEMDOCK using pharmacological interactions and post-screening analysis BMC Bioinf. 12 1 2011 1 11 http://www.biomedcentral.com/1471-2105/12/S1/S33 

  34. Hurwitz S.J. Schinazi R.F. Practical considerations for developing nucleoside reverse transcriptase inhibitors Drug Discov 9 3 2012 e183 e193 10.1016/j.ddtec.2012.09.003 Today Technol 

  35. Kar T. Nardaria U. Basak S. Deb D. Castiglione F. Mueller D.M. Srivastava A.P. A candidate multi-epitope vaccine against SARS-CoV-2 Sci. Rep. 10 2020 10895 10.1038/s41598-020-67749-1 32616763 

  36. Kashyap S. Comparative in Silico studies on phytochemicals of ocimum as natural inhibitors of Ebola VP-35 protein Indo American J. Pharm. Res. 498?511 2019 10.5281/zenodo.3524053 

  37. Khodadadi E. Maroufi P. Khodadadi E. Esposito I. Ganbarov K. Esposito S. Yousefi M. Zeinalzadeh E. Kafil H.S. Study of combining virtual screening and antiviral treatments of the Sars-CoV-2 (Covid-19) Microb. Pathog. 146 2020 1 9 10.1016/j.micpath.2020.104241 

  38. Kiemer L. Lund O. Brunak S. Blom N. Coronavirus 3CLpro proteinase cleavage sites: possible relevance to SARS virus pathology Bioinformatics 5 72 2004 1 9 http://www.biomedcentral.com/1471-2105/5/72 14706121 

  39. Kiemer L. Bendsten J.D. Blom N. NetAcet: prediction of N-terminal acetylation sites Bioinformatics 21 7 2005 1289 10.1093/bioinformatics/bti130 1270 

  40. Kim S. Thiessen P.A. Bolton E.E. Chen J. Fu G. Gindulyte A. Han L. He J. He S. Shoemaker B.A. Wang J. Yu B. Zhang J. Bryant S.H. PubChem substance and compound databases Nucleic Acids Res. 44 2015 1202 1213 10.1093/nar/gkv951 

  41. Klausen M.S. Jespersen M.C. Nielsen H. Jensen K.K. Jurtz V.I. Sonderby C.K. Sommer M.O.A. Winther O. Nielsen M. Petersen B. Marcatili P. NetSurfP-2.0: improved prediction of protein structural features by integrated deep learning Proteins 87 6 2019 520 527 10.1002/prot.25674 30785653 

  42. Ko J. Park H. Heo L. Seok C. GalxyWEBserver for protein structure prediction and refinement Nucleic Acids Res. 40 2012 W294 W297 https://doi:10.1093/nar/gks493 22649060 

  43. Kota P. Ding F. Ramachandran S. Dokholyan N.V. Gaia: automated quality assessment of protein structure models Bioinformatics 27 16 2011 2209 2215 10.1093/bioinformatics/btr374 21700672 

  44. Kozlowski L.P. Bujnicki J.M. MetaDisorder: a meta-server for the prediction of intrinsic disorder in proteins BMC Bioinf. 13 111 2012 1 11 http://www.biomedcentral.com/1471-2105/13/111 

  45. Kumar S. Stecher G. Li M. Knyaz C. Tamura K. Mega X: molecular evolutionary genetics analysis across computing platforms Mol. Biol. Evol. 35 6 2018 1547 1549 10.1093/molbev/msy096 29722887 

  46. Kurgan L. Razib A.A. Aghakhani S. Dick S. Mizianty M. Jahandideh S. CRYSTALP2: sequence-based protein crystallization propensity prediction BMC Struct. Biol. 9 50 2009 1 14 10.1186/1472-6807-9-50 19128473 

  47. Lan J. Ge J. Yu J. Shan S. Zhou H. Fan S. Xhang Q. Shi X. Wang Q. Zhang L. Wang X. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor Nature 1581 2020 215 220 10.1038/s41586-020-2180-5 

  48. Leandro K.C. Moreira J.C. Farias P.A.M. Determination of Zalcitabine in medicaments by differential pulse voltammetry J. Pharm. (Lahore) 1?6 2013 10.1155/2013/495814 

  49. Li F. Li W. Farzan M. Harrison S.C. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Science 309 5742 2005 1864 1868 10.1126/science.1116480 16166518 

  50. Li X. Wang W. Zhao X. Zai J. Zhao Q. Li Y. Chaillon A. Transmission dynamics and evolutionary history of 2019­nCoV J. Med. Virol. 92 2020 501 511 10.1002/jmv.25701 32027035 

  51. Lovell S.C. Davis I.W. Arendall W.B. III de Bakker P.I.W. Word J.M. Prisant M.G. Richardson J.S. Richardson D.C. Structure validation by Calpha geometry: phi,psi and Cbeta deviation Protein Struct. Funct. Genet. 50 3 2003 437 450 10.1002/prot.10286 

  52. Maiti R. Van Domselaar G.H. Zhang H. Wishart D.S. SuperPose: a simple server for sophisticated structural superposition Nucleic Acids Res. 32 2004 590 594 10.1093/nar/gkh477 14752047 

  53. Malek A.E. Granwehr B.P. Kontoyiannis D.P. Doxycycline as a potential partner of COVID-19 therapies IDCases 21 2020 1 3 10.1016/j.idcr.2020.e00864 

  54. McGuffin L.J. Bryson K. Jones D.T. The PSIPRED protein structure prediction server Bioinformatics 16 4 2000 404 405 10.1093/bioinformatics/16.4.404 10869041 

  55. Meszaros B. Erdos G. Dosztanyi Z. IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding Nucleic Acids Res. 46 2018 329 337 10.1093/nar/gky384 

  56. Mizianty M.J. Kurgan L. Sequence-based prediction of protein crystallization, purification and production propensity Bioinformatics 27 2011 24 33 10.1093/bioinformatics/btr229 

  57. Narkhede R.R. Cheke R.S. Ambhore J.P. Shinde S.D. The molecular docking study of potential drug candidates showing Anti-COVID-19 activity by exploring of therapeutic targets of SARS-CoV-2 Eurasian J. Med. Oncol. 4 3 2020 185 195 10.14744/ejmo.2020.31503 

  58. Nielsen H. Predicting secretory proteins with SignalP Methods Mol. Biol. 1611 2017 59 73 10.1007/978-1-4939-7015-5_6 28451972 

  59. Ortega J.T. Serrano M.L. Pujol F.H. Rangel H.R. Role of Changes in SARS-COV-2 Spike protein in the interaction with the human ace2 receptor: an in silico analysis Exp. Clin. Sci. 19 2020 410 417 10.17179/excli2020-1167 

  60. Park H. Seok C. Refinement of unreliable local regions in template-based protein models Proteins 80 2012 1974 1986 10.1002/prot.24086 22488760 

  61. Pettersen E.F. Goddard T.D. Huang C.C. Couch G.S. Greenblatt D.M. Meng E.C. Ferrin T.E. UCSF Chimera―a visualization system for exploratory research and analysis J. Comput. Chem. 25 2004 1605 1612 10.1002/jcc.20084 15264254 

  62. Piovesan D. Tabaro F. Paladin L. Necci M. Micetic I. Camilloni C. Davey N. Dosztanyi Z. Meszaros B. Monzon A.M. Parisi G. Schad E. Sormanni P. Tompa P. Vendruscolo M. Vranken W.F. Tossato S.C.E. MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins Nucleic Acids Res. 46 2018 471 476 10.1093/nar/gkx1071 

  63. Pradeepkiran J.A. Kumar K.K. Kumar Y.N. Bhaskar M. Modeling, molecular dynamics, and docking assessment of transcription factor rho: a potential drug target in Brucella melitensis 16M Drug Des. Dev. Ther. 9 2015 1897 1912 10.2147/DDDT.S77020 

  64. Prajapat M. Sarma P. Shekhar N. Avti P. Sinha S. Kaur H. Kumar S. Bhattacharyya A. Kumar H. Bansal S. Medji B. Drug targets for corona virus: a systematic review Indian J. Pharmacol. 52 1 2020 56 65 10.4103/ijp.IJP_115_20 32201449 

  65. Pramod K. Ansari S.H. Ali J. Eugenol: a natural compound with versatile pharmacological actions Nat. Prod. Commun. 5 12 2010 1999 2006 10.1177/F1934578X1000501236 21299140 

  66. Ramachandran S. Kota P. Ding F. Dokholyan N.V. Automated minimization of steric clashes in protein structures Proteins 79 1 2011 261 270 10.1002/prot.22879 21058396 

  67. Robson B. COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles' heel conserved region to minimize probability of escape mutations and drug resistance Comput. Biol. Med. 2020 1 67 10.1016/j.compbiomed.2020.103749 

  68. Romero P. Obradovic Z. Kissinger C. Villafranca J.E. Dunker A.K. Identifying disordered regions in proteins from amino acid sequence Neural Network. 1997 1 6 

  69. Sadati S.M. Gheibi N. Ranjbar S. Hashemzadeh M.S. Docking study of flavonoid derivatives as potent inhibitors of influenza H1N1 virus neuraminidase Biomed. Rep. 10 2019 33 38 10.3892/br.2018.1173 30588301 

  70. Saitou N. Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees Mol. Biol. Evol. 4 4 1987 406 425 10.1093/oxfordjournals.molbev.a040454 3447015 

  71. Sali A. Blundell T.L. Comparative protein modelling by satisfaction of spatial restraints J. Mol. Biol. 234 3 1993 779 815 10.1006/jmbi.1993.1626 8254673 

  72. Sarkar B. Ullah M.A. Araf Y. A systematic and reverse vaccinology approach to design novel subunit vaccines against Dengue virus type-1 (DENV-1) and human Papillomavirus-16 (HPV-16) Inform. Med. Unlocked 19 2020 1 32 10.1016/j.imu.2020.100343 

  73. Sayers E.W. Agarwala R. Bolton E.E. Brister J.R. Canese K. Clark K. Connor R. Fiorini N. Funk K. Hefferon T. Holmes J.B. Kim S. Kimchi A. Kitts P.A. Lathrop S. Lu Z. Madden T.L. Marchler-Bauer A. Phan L. Schneider V.A. Schoch C.L. Pruitt K.D. Ostell J. Database resources of the national center for Biotechnology information Nucleic Acids Res. 47 2019 23 28 10.1093/nar/gky1069 

  74. Seeliger D. de Groot B.L. Ligand docking and binding site analysis with PyMOL and Autodock/Vina J. Comput. Aided Mol. Des. 24 2010 417 422 10.1007/s10822-010-9352-6 20401516 

  75. Senanayake S.L. Drug repurposing strategies for COVID-19 Future Drug 2020 1 3 10.4155/fdd-2020-0010 Discov. 

  76. Shah B. Modi P. Sagar S.R. In silico studies on therapeutic agents for COVID-19: drug repurposing approach Life Sci. 252 2020 1 12 10.1016/j.lfs.2020.117652 

  77. Slabinski L. Jarozewski L. Rychlewski L. Wilson I.A. Lesley S.A. Godzik A. XtalPred: a web server for prediction of protein crystallizability Bioinformatics 23 24 2007 3403 3405 10.1093/bioinformatics/btm477 17921170 

  78. Steentoft C. Vakhrushev S.Y. Joshi H.J. Kong Y. Vester-Christensen M.B. Scholdager K.T.-B.G. Lavrsen K. Dabelsteen S. Pedersen N.B. Marcos-Silva L. Gupta R. Bennet E.P. Mandel U. Brunak S. Wandall H.H. Levery S.B. Clausen H. EMBO J. 32 10 2013 1478 1488 10.1038/emboj.2013.79 23584533 

  79. Thompson M. ArgusLab 4.0.1 2004 Planaria software LLC Seattle, Wash, USA 

  80. Uno Y. Camostat mesilate therapy for COVID-19 Intern. Emerg. Med. 2020 1 2 10.1007/s11739-020-02345-9 31834587 

  81. Vacic V. Uversky V.N. Dunker A.K. Lonardi S. Composition Profiler: a tool for discovery and visualization of amino acid composition differences BMC Bioinf. 8 211 2007 1 7 10.1186/1471-2105-8-211 

  82. Walls A.C. Park Y.J. Tortoricci M.A. Wall A. McGuire A.T. Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein Cell 180 2020 281 292 10.1016/j.cell.2020.02.058 

  83. Waterhouse A.M. Procter J.B. Martin D.M.A. Clamp M. Barton G.J. Jalview Version 2―a multiple sequence alignment editor and analysis workbench Bioinformatics 25 9 2009 1189 1191 10.1093/bioinformatics/btp033 19151095 

  84. Webb B. Sali A. Comparative protein structure modeling using MODELLER Curr. Protoc. Bioinformatics 54 5 2017 1 37 10.1002/cpbi.3 6 

  85. Weiss S.R. Navas-Martin S. Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus Microbiol. Mol. Biol. Rev. 69 4 2005 635 664 10.1128/MMBR.69.4.635?664.2005 16339739 

  86. Weng G. Wang E. Wang Z. Liu H. Zhu F. Li D. Hou T. HawkDock: a web server to predict and analyze the protein?protein complex based on computational docking and MM/GBSA Nucleic Acids Res. 47 2019 322 330 10.1093/nar/gkz397 

  87. Wu C. Liu Y. Yang Y. Zhang P. Zhong W. Wang Y. Wang Q. Xu Y. Li M. Li X. Zheng M. Chen L. Li H. Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods Acta Pharm. Sin. B 10 5 2020 766 788 10.1016/j.apsb.2020.02.008 32292689 

  88. Wu D. Wu T. Liu Q. Yang Z. The SARS-CoV-2 outbreak: what we know Int. J. Infect. Dis. 94 2020 44 48 10.1016/j.ijid.2020.03.004 32171952 

  89. Yan R. Zhang Y. Li Y. Xia L. Guo Y. Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 Science 367 2020 1444 1448 10.1126/science.abb2762 32132184 

  90. Yang J. Roy A. Zhang Y. Protein?ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment Bioinformatics 29 20 2013 2588 2595 10.1093/bioinformatics/btt447 23975762 

  91. Yang J. Roy A. Zhang Y. BioLiP: a semi-manually curated database for biologically relevant ligand?protein interactions Nucleic Acids Res. 41 2013 1096 1103 10.1093/nar/gks966 

  92. Zhou Y. Hou Y. Shen J. Huang Y. Martin W. Cheng F. Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2 Cell Discov 6 14 2020 1 18 10.1038/s41421-020-0153-3 31934347 

  93. Zhu N. Zhang D. Wang W. Li X. Yang B. Song J. Zhao X. Huang B. Shi W. Lu R. Niu P. Zhan F. Ma X. Wang D. Xu W. Wu G. Gao G.F. tan W. A novel coronavirus from patients with pneumonia in China, 2019 N. Engl. J. Med. 382 8 2020 727 733 10.1056/NEJMoa2001017 31978945 

  94. Zuckerkandl E. Pauling L. Evolutionary divergence and convergence, in proteins Evolving Genes and Proteins by V. Bryson and H.J. Vogel 1965 Academic Press New York 97 166 

관련 콘텐츠

오픈액세스(OA) 유형

GREEN

저자가 공개 리포지터리에 출판본, post-print, 또는 pre-print를 셀프 아카이빙 하여 자유로운 이용이 가능한 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로