[논문]Thin film composite hollow fibre membrane for pharmaceutical concentration and solvent recovery

Goh, Keng Siang; Chen, Yunfeng; Chong, Jeng Yi; Bae, Tae Hyun; Wang, Rong

doi:10.1016/j.memsci.2020.119008

[해외논문] Thin film composite hollow fibre membrane for pharmaceutical concentration and solvent recovery 원문보기

Journal of membrane science, v.621, 2021년, pp.119008 -

Goh, Keng Siang (Singapore Membrane Technology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University) , Chen, Yunfeng (Singapore Membrane Technology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University) , Chong, Jeng Yi (Singapore Membrane Technology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University) , Bae, Tae Hyun (Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology) , Wang, Rong (Singapore Membrane Technology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University)

Abstract ▼ AI-Helper

Abstract A 100-piece hollow fibre thin-film composite membrane module was successfully developed for pharmaceutical concentration and solvent recovery. To increase its packing density, thinner P84 polyimide hollow fibre substrates were spun using a smaller spinneret. The substrates were subsequently cross-linked with hexamethylene diamine to achieve organic solvent resistance. An MPD-based thin-film composite was synthesized through interfacial polymerisation to increase selectivity for solutes of less than 300 Da. The thin-film composite was then solvent-activated using N,N-dimethylformamide to increase its solvent permeability. The resulting membrane exhibited excellent performance with 24.2 l m−2 h−1 bar−1 acetone permeability and 90.1% methyl red (269 Da) rejection. In addition, the solvent-activated membrane maintained its performance for prolonged period, demonstrating the scalability of the thin-film composite fabrication process and stability of solvent-activated membranes. The membrane was also able to concentrate levofloxacin (361 Da) from 500 ppm to 20,000 ppm in acetone using a batch process, showing promising results for pharmaceutical applications. Highlights 100-piece thin-film composite OSN membrane was successfully fabricated. 7-day filtration test showed stable organic solvent nanofiltration (OSN) performance. High acetone permeability of 24.2 l m−2 h−1 bar−1 and 90.1% methyl red rejection. Active pharmaceutical ingredient was concentrated to 2 wt%. Graphical abstract [DISPLAY OMISSION]

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