[논문]Ishophloroglucin A Isolated from Ishige okamurae Suppresses Melanogenesis Induced by α-MSH: In Vitro and In Vivo

Li, Xining; Yang, Hye-Won; Jiang, Yunfei; Oh, Jae-Young; Jeon, You-Jin; Ryu, Bomi

doi:10.3390/md18090470

[해외논문] Ishophloroglucin A Isolated from Ishige okamurae Suppresses Melanogenesis Induced by α-MSH: In Vitro and In Vivo 원문보기

Marine drugs, v.18 no.9, 2020년, pp.470 -

Li, Xining (Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea) , Yang, Hye-Won (lixn887@nenu.edu.cn (X.L.)) , Jiang, Yunfei (koty221@naver.com (H.-W.Y.)) , Oh, Jae-Young (jiangyunfei0310@gmail.com (Y.J.)) , Jeon, You-Jin (ojy0724@naver.com (J.-Y.O.)) , Ryu, Bomi (Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea)

Abstract ▼ AI-Helper

Diphlorethohydroxycarmalol (DPHC) isolated from Ishige okamurae (IO) showed potential whitening effects against UV-B radiation. However, the components of IO as well as their molecular mechanism against α-melanocyte-stimulating hormone (α-MSH) have not yet been investigated. Thus, this study aimed to investigate the inhibitory effects of Ishophloroglucin A (IPA), a phlorotannin isolated from brown algae IO, and its crude extract (IOE), in melanogenesis in vivo in an α-MSH-induced zebrafish model and in B16F10 melanoma cells in vitro. Molecular docking studies of the phlorotannins were carried out to determine their inhibitory effects and to elucidate their mode of interaction with tyrosinase, a glycoprotein related to melanogenesis. In addition, morphological changes and melanin content decreased in the α-MSH-induced zebrafish model after IPA and IOE treatment. Furthermore, Western blotting results revealed that IPA upregulated the extracellular related protein expression in α-MSH-stimulated B16F10 cells. Hence, these results suggest that IPA isolated from IOE has a potential for use in the pharmaceutical and cosmetic industries.

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참고문헌 (43)

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[해외논문] Ishophloroglucin A Isolated from Ishige okamurae Suppresses Melanogenesis Induced by α-MSH: In Vitro and In Vivo 원문보기

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[해외논문] Ishophloroglucin A Isolated from Ishige okamurae Suppresses Melanogenesis Induced by α-MSH: In Vitro and In Vivo 원문보기

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