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Amyloid precursor protein metabolism is regulated toward alpha-secretase pathway by Ginkgo biloba extracts

Neurobiology of disease, v.16 no.2, 2004년, pp.454 - 460  

Colciaghi, Francesca (Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy) ,  Borroni, Barbara (Department of Medical Sciences, Neurologic Clinic, University of Brescia, Brescia, Italy) ,  Zimmermann, Martina (Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy) ,  Bellone, Camilla (Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy) ,  Longhi, Annalisa (Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy) ,  Padovani, Alessandro (Department of Medical Sciences, Neurologic Clinic, University of Brescia, Brescia, Italy) ,  Cattabeni, Flaminio (Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy) ,  Christen, Yves (IPSEN Foundation, Paris, France) ,  Di Luca, Monica (Corresponding author. Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milano, Via Balzaretti,)

Abstract AI-Helper 아이콘AI-Helper

AbstractClinical trials report that Ginkgo biloba extracts (e.g., EGb761) reduce cognitive symptoms in age-associated memory impairment and dementia, including Alzheimer disease (AD). However, the mechanisms behind their neuroprotective ability remain to be fully established.In this study, the effec...

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