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Objectives : Brain-derived neurotrophic factor(BDNF) belongs to a family of neurotrophic factors and has been demonstrated to promote the survival, differentiation, and maintenance of a broad variety of central nervous system neurons. Several reports have suggested that the BDNF gene is associated w...

Objectives : Brain-derived neurotrophic factor(BDNF) belongs to a family of neurotrophic factors and has been demonstrated to promote the survival, differentiation, and maintenance of a broad variety of central nervous system neurons. Several reports have suggested that the BDNF gene is associated with variable psychatric disorders and neurologic disesases. We investigated the association of BDNF Val66Met polymorphism with schizophrenia and tardive dyskinesia(TD) to evaluate candidate BDNF gene for association with drug-induced TD. Methods : 161 schizophrenic patients(TD=83, non-TD=78) and 95 normal controls were included in the study. Tardive dyskinesia was assessed by the Abnormal Involuntary Movement Scale(AMIS). We examined the BDNF Val66Met genotype distribution and allele frequency. Statistical analysis was used to test the association between this polymorphism and TD development in the schizophrenic patients. Results : There were no significant differences in the genotype distribution and allele frequency of the BDNF Val66Met polymorphism between schizophrenic patients with and without tardive dyskinesia, normal controls. Conclusion : Our findings suggest that it is unlikely that the BDNF Val66Met polymorphism play a major role in the pathogenesis of TD in the Korean sample.

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