$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Basis for the barrier abnormality in atopic dermatitis: Outside-inside-outside pathogenic mechanisms 원문보기

The Journal of allergy and clinical immunology : official organ of American Academy of Allergy, v.121 no.6, 2008년, pp.1337 - 1343  

Elias, Peter M. (Dermatology Service, Veterans Affairs Medical Center, San Francisco, Calif) ,  Hatano, Yutaka (Dermatology Service, Veterans Affairs Medical Center, San Francisco, Calif) ,  Williams, Mary L. (Department of Dermatology, University of California, San Francisco, Calif)

Abstract AI-Helper 아이콘AI-Helper

Until quite recently, the pathogenesis of atopic dermatitis (AD) has been attributed to primary abnormalities of the immune system. Intensive study revealed the key roles played by TH1/TH2 cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the evolution of t...

주제어

참고문헌 (89)

  1. J Allergy Clin Immunol Leung 104 suppl S99 1999 10.1016/S0091-6749(99)70051-5 Pathogenesis of atopic dermatitis 

  2. Lancet Leung 361 151 2003 10.1016/S0140-6736(03)12193-9 Atopic dermatitis 

  3. J Clin Invest Leung 113 651 2004 10.1172/JCI21060 New insights into atopic dermatitis 

  4. J Am Acad Dermatol Leung 44 suppl S1 2001 10.1067/mjd.2001.109815 Cellular and immunologic mechanisms in atopic dermatitis 

  5. J Allergy Clin Immunol Leung 105 860 2000 10.1067/mai.2000.106484 Atopic dermatitis: new insights and opportunities for therapeutic intervention 

  6. J Invest Dermatol Elias 125 183 2005 10.1111/j.0022-202X.2005.23668.x Stratum corneum defensive functions: an integrated view 

  7. Exp Dermatol Elias 14 719 2005 10.1111/j.1600-0625.2005.00363.x Interactions among stratum corneum defensive functions 

  8. Semin Immunopathol Elias 29 3 2007 10.1007/s00281-007-0060-9 The skin barrier as an innate immune element 

  9. Arch Dermatol Sugarman 139 1417 2003 10.1001/archderm.139.11.1417 The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease 

  10. Acta Derm Venereol Seidenari 75 429 1995 10.2340/0001555575429433 Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin 

  11. J Dermatol Sci Proksch 43 159 2006 10.1016/j.jdermsci.2006.06.003 Skin barrier function, epidermal proliferation and differentiation in eczema 

  12. J Am Acad Dermatol Chamlin 47 198 2002 10.1067/mjd.2002.124617 Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity 

  13. Acta Derm Venereol Eberlein-Konig 80 188 2000 10.1080/000155500750042943 Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children 

  14. J Allergy Clin Immunol Boguniewicz 117 suppl S475 2006 10.1016/j.jaci.2005.10.018 10. Atopic dermatitis 

  15. Clin Exp Immunol Baker 144 1 2006 10.1111/j.1365-2249.2005.02980.x The role of microorganisms in atopic dermatitis 

  16. Immunol Allergy Clin North Am Elias 17 417 1997 10.1016/S0889-8561(05)70318-0 Relationship of the epidermal permeability barrier to irritant contact dermatitis 

  17. Am J Contact Dermat Elias 10 119 1999 10.1016/S1046-199X(99)90054-4 Epidermal pathogenesis of inflammatory dermatoses 

  18. Arch Dermatol Elias 137 1079 2001 Does the tail wag the dog? Role of the barrier in the pathogenesis of inflammatory dermatoses and therapeutic implications 

  19. Contact Dermatitis Taieb 41 177 1999 10.1111/j.1600-0536.1999.tb06125.x Hypothesis: from epidermal barrier dysfunction to atopic disorders 

  20. Br J Dermatol Cork 149 582 2003 10.1046/j.1365-2133.2003.05595.x Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse 

  21. Arch Dermatol Aly 113 780 1977 10.1001/archderm.113.6.780 Microbial flora of atopic dermatitis 

  22. J Allergy Clin Immunol Boguniewicz 118 40 2006 10.1016/j.jaci.2006.04.044 Atopic dermatitis 

  23. Contact Dermatitis Ramirez de Knott 54 92 2006 10.1111/j.0105-1873.2006.00774.x Cutaneous hypersensitivity to Malassezia sympodialis and dust mite in adult atopic dermatitis with a textile pattern 

  24. J Invest Dermatol Aberg 2007 Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers 

  25. J Invest Dermatol Denda 111 873 1998 10.1046/j.1523-1747.1998.00364.x Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: implication for seasonal exacerbations of inflammatory dermatoses 

  26. Adv Lipid Res Elias 24 1 1991 10.1016/B978-0-12-024924-4.50005-5 Structural and lipid biochemical correlates of the epidermal permeability barrier 

  27. J Invest Dermatol Caubet 122 1235 2004 10.1111/j.0022-202X.2004.22512.x Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7 

  28. J Invest Dermatol Brattsand 124 198 2005 10.1111/j.0022-202X.2004.23547.x A proteolytic cascade of kallikreins in the stratum corneum 

  29. J Invest Dermatol Braff 124 394 2005 10.1111/j.0022-202X.2004.23443.x Keratinocytes store the antimicrobial peptide cathelicidin in lamellar bodies 

  30. Exp Mol Pathol Oren 74 180 2003 10.1016/S0014-4800(02)00023-0 In human epidermis, beta-defensin 2 is packaged in lamellar bodies 

  31. J Clin Invest Aberg 117 3339 2007 10.1172/JCI31726 Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice 

  32. Nat Genet Walley 29 175 2001 10.1038/ng728 Gene polymorphism in Netherton and common atopic disease 

  33. J Invest Dermatol Hachem 126 1609 2006 10.1038/sj.jid.5700288 Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome 

  34. J Invest Dermatol Komatsu 118 436 2002 10.1046/j.0022-202x.2001.01663.x Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides 

  35. J Invest Dermatol Vasilopoulos 123 62 2004 10.1111/j.0022-202X.2004.22708.x Genetic association between an AACC insertion in the 3′UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis 

  36. J Invest Dermatol Hansson 118 444 2002 10.1046/j.0022-202x.2001.01684.x Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis 

  37. Acta Derm Venereol Hubiche 87 499 2007 10.2340/00015555-0329 Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort 

  38. Br J Dermatol Folster-Holst 152 1365 2005 10.1111/j.1365-2133.2005.06602.x Lack of association of SPINK5 polymorphisms with nonsyndromic atopic dermatitis in the population of Northern Germany 

  39. J Allergy Clin Immunol Jongepier 115 486 2005 10.1016/j.jaci.2004.12.013 Polymorphisms in SPINK5 are not associated with asthma in a Dutch population 

  40. J Invest Dermatol Hachem 121 345 2003 10.1046/j.1523-1747.2003.12365.x pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion 

  41. Acta Derm Venereol Di Nardo 78 27 1998 10.1080/00015559850135788 Ceramide and cholesterol composition of the skin of patients with atopic dermatitis 

  42. J Invest Dermatol Imokawa 96 523 1991 10.1111/1523-1747.ep12470233 Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? 

  43. J Invest Dermatol Hachem 126 2074 2006 10.1038/sj.jid.5700351 Serine protease signaling of epidermal permeability barrier homeostasis 

  44. Am J Pathol Demerjian 172 86 2008 10.2353/ajpath.2008.070161 Permeability barrier requirements regulate epidermal cornification: role of caspase 14 and the protease-activated receptor type 2 

  45. J Am Acad Dermatol Sator 48 352 2003 10.1067/mjd.2003.105 Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis 

  46. J Invest Dermatol Irvine 126 1200 2006 10.1038/sj.jid.5700365 Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis 

  47. Nat Genet Palmer 38 441 2006 10.1038/ng1767 Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis 

  48. Nat Genet Smith 38 337 2006 10.1038/ng1743 Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris 

  49. J Allergy Clin Immunol Weidinger 118 214 2006 10.1016/j.jaci.2006.05.004 Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations 

  50. Nat Genet Hudson 38 399 2006 10.1038/ng0406-399 Skin barrier function and allergic risk 

  51. J Invest Dermatol Segre 126 1202 2006 10.1038/sj.jid.5700367 Epidermal differentiation complex yields a secret: mutations in the cornification protein filaggrin underlie ichthyosis vulgaris 

  52. J Invest Dermatol Sandilands 127 1282 2007 10.1038/sj.jid.5700876 Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis 

  53. J Invest Dermatol Barker 127 564 2007 10.1038/sj.jid.5700587 Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood 

  54. J Invest Dermatol Stemmler 127 722 2007 10.1038/sj.jid.5700579 Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis 

  55. J Invest Dermatol Weidinger 127 724 2007 10.1038/sj.jid.5700630 Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis 

  56. Presland 111 2006 Skin barrier Profilaggrin and the fused S100 family of calcium-binding proteins 

  57. Dev Biol Scott 115 84 1986 10.1016/0012-1606(86)90230-7 Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment 

  58. J Invest Dermatol Krien 115 414 2000 10.1046/j.1523-1747.2000.00083.x Evidence for the existence of a self-regulated enzymatic process within human stratum corneum-an unexpected role for urocanic acid 

  59. J Invest Dermatol Hachem 119 258 2002 Increased stratum corneum pH promotes activation and release of primary cytokines from the stratum corneum attributable to activation of serine proteases 

  60. J Immunol Nylander-Lundqvist 157 1699 1996 10.4049/jimmunol.157.4.1699 IL-1 beta activation in human epidermis 

  61. J Invest Dermatol Sandilands 126 1770 2006 10.1038/sj.jid.5700459 Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis 

  62. Nat Genet Sandilands 39 650 2007 10.1038/ng2020 Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema 

  63. J Allergy Clin Immunol Cork 118 3 2006 10.1016/j.jaci.2006.04.042 New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions 

  64. Arch Dermatol Garg 137 53 2001 10.1001/archderm.137.1.53 Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders 

  65. J Invest Dermatol Altemus 117 309 2001 10.1046/j.1523-1747.2001.01373.x Stress-induced changes in skin barrier function in healthy women 

  66. Am J Physiol Regul Integr Comp Physiol Denda 278 R367 2000 10.1152/ajpregu.2000.278.2.R367 Stress alters cutaneous permeability barrier homeostasis 

  67. Am J Physiol Regul Integr Comp Physiol Choi 291 R1657 2006 10.1152/ajpregu.00010.2006 Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function 

  68. J Invest Dermatol Choi 124 587 2005 10.1111/j.0022-202X.2005.23589.x Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity 

  69. J Invest Dermatol Kurahashi 2007 IL-4 suppresses the recovery of cutaneous permeability barrier functions in vivo 

  70. J Invest Dermatol Hatano 124 786 2005 10.1111/j.0022-202X.2005.23651.x Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factor-alpha and interferon-gamma in human epidermis 

  71. J Allergy Clin Immunol Howell 120 150 2007 10.1016/j.jaci.2007.04.031 Cytokine modulation of atopic dermatitis filaggrin skin expression 

  72. Cytokine Kobayashi 28 186 2004 10.1016/j.cyto.2004.08.003 Reciprocal regulation of permeability through a cultured keratinocyte sheet by IFN-gamma and IL-4 

  73. N Engl J Med Ong 347 1151 2002 10.1056/NEJMoa021481 Endogenous antimicrobial peptides and skin infections in atopic dermatitis 

  74. Arch Dermatol Miller 124 209 1988 10.1001/archderm.124.2.209 In vitro and in vivo antistaphylococcal activity of human stratum corneum lipids 

  75. Exog Dermatol Fluhr 1 163 2002 10.1159/000066140 Stratum corneum pH: formation and function of the “acid mantle 

  76. J Invest Dermatol Bibel 98 269 1992 10.1111/1523-1747.ep12497842 Antimicrobial activity of sphingosines 

  77. Cell Host Microbe Clarke 1 199 2007 10.1016/j.chom.2007.04.005 The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin 

  78. J Immunol Nomura 171 3262 2003 10.4049/jimmunol.171.6.3262 Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes 

  79. J Invest Dermatol Zaiou 120 810 2003 10.1046/j.1523-1747.2003.12132.x Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence 

  80. J Pathol Komatsuzawa 208 249 2006 10.1002/path.1898 Innate defences against methicillin-resistant Staphylococcus aureus (MRSA) infection 

  81. J Invest Dermatol Kisich 127 2368 2007 10.1038/sj.jid.5700861 The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3 

  82. J Invest Dermatol Lomholt 125 977 2005 10.1111/j.0022-202X.2005.23916.x Staphylococcus aureus clonal dynamics and virulence factors in children with atopic dermatitis 

  83. Br J Dermatol Wehner 145 302 2001 10.1046/j.1365-2133.2001.04352.x Staphylococcus aureus enterotoxins induce histamine and leukotriene release in patients with atopic eczema 

  84. Int Arch Allergy Immunol Lehmann 135 306 2004 10.1159/000082324 Staphylococcal enterotoxin-B-mediated stimulation of interleukin-13 production as a potential aetiologic factor in eczema in infants 

  85. Exp Dermatol Langer 16 124 2007 10.1111/j.1600-0625.2006.00523.x Staphylococcus aureus-derived enterotoxins enhance house dust mite-induced patch test reactions in atopic dermatitis 

  86. J Clin Invest Leung 92 1374 1993 10.1172/JCI116711 Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens 

  87. Chem Immunol Allergy Gould 93 106 2007 10.1159/000100861 The allergic march from Staphylococcus aureus superantigens to immunoglobulin E 

  88. J Allergy Clin Immunol Sonkoly 117 411 2006 10.1016/j.jaci.2005.10.033 IL-31: a new link between T cells and pruritus in atopic skin inflammation 

  89. J Invest Dermatol Sugarman 2008 A topical lipid-based barrier repair formulation (EpiCeram™ cream) is high-effective monotherapy for moderate-to-severe pediatric atopic dermatitis 

관련 콘텐츠

오픈액세스(OA) 유형

GREEN

저자가 공개 리포지터리에 출판본, post-print, 또는 pre-print를 셀프 아카이빙 하여 자유로운 이용이 가능한 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로